ES8704499A1 - Un procedimiento para la preparacion de una trans-octahidro-oxazolo(4,5-g)quinolina - Google Patents

Un procedimiento para la preparacion de una trans-octahidro-oxazolo(4,5-g)quinolina

Info

Publication number
ES8704499A1
ES8704499A1 ES545859A ES545859A ES8704499A1 ES 8704499 A1 ES8704499 A1 ES 8704499A1 ES 545859 A ES545859 A ES 545859A ES 545859 A ES545859 A ES 545859A ES 8704499 A1 ES8704499 A1 ES 8704499A1
Authority
ES
Spain
Prior art keywords
oxazolo
quinolines
octahydro
dopamine agonists
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545859A
Other languages
English (en)
Other versions
ES545859A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES545859A0 publication Critical patent/ES545859A0/es
Publication of ES8704499A1 publication Critical patent/ES8704499A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UNA TRANS-OCTAHIDRO-OXAZOLO 4,5-G QUINOLINA. CONSISTE EN HACER REACCIONAR A UN DERIVADO DE UREA DE FORMULA (II) CON UN 7-BROMO-6-CETO, DERIVADO DE FORMULA (III), EN DISOLVENTES ORGANICOS POLARES COMO ALCANOLES DE C 1 A 3 Y ENTRE 40J Y 100JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: R, H, BENCILO Y ALQUILO DE C 1 A 3 DE CADENA LINEAL Y R1, H, ALQUILO DE C 1 A 3, NH-ALQUILO DE C 1 A 3 Y OTROS. SE UTILIZA PARA EL TRATAMIENTO DE LA ENFERMEDAD DE PARKINSON, Y DE LAS DISFUNCIONES SEXUALES (ANSIEDAD O DEPRESION).
ES545859A 1984-08-02 1985-08-02 Un procedimiento para la preparacion de una trans-octahidro-oxazolo(4,5-g)quinolina Expired ES8704499A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63723284A 1984-08-02 1984-08-02

Publications (2)

Publication Number Publication Date
ES545859A0 ES545859A0 (es) 1987-04-01
ES8704499A1 true ES8704499A1 (es) 1987-04-01

Family

ID=24555086

Family Applications (2)

Application Number Title Priority Date Filing Date
ES545859A Expired ES8704499A1 (es) 1984-08-02 1985-08-02 Un procedimiento para la preparacion de una trans-octahidro-oxazolo(4,5-g)quinolina
ES551964A Expired ES8800231A1 (es) 1984-08-02 1986-02-13 Un procedimiento para la preparacion de una trans-octahidro-oxazolo 4,5-g quinolina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES551964A Expired ES8800231A1 (es) 1984-08-02 1986-02-13 Un procedimiento para la preparacion de una trans-octahidro-oxazolo 4,5-g quinolina

Country Status (19)

Country Link
EP (1) EP0172697B1 (es)
JP (1) JPH0670063B2 (es)
KR (1) KR880001430B1 (es)
AR (1) AR240822A1 (es)
AT (1) ATE67766T1 (es)
AU (1) AU569406B2 (es)
CA (1) CA1292742C (es)
DE (1) DE3584205D1 (es)
DK (1) DK349185A (es)
ES (2) ES8704499A1 (es)
GR (1) GR851895B (es)
HU (1) HU193338B (es)
IE (1) IE58695B1 (es)
IL (1) IL75991A0 (es)
NZ (1) NZ212946A (es)
PH (1) PH22541A (es)
PT (1) PT80899B (es)
SU (1) SU1421258A3 (es)
ZA (1) ZA855830B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826986A (en) * 1986-06-16 1989-05-02 Eli Lilly And Company 6-Oxo-trans-octa- and decahydroquinolines
US4762843A (en) * 1986-09-15 1988-08-09 Warner-Lambert Company Hetero [f] fused carbocyclic pyridines as dopaminergic agents
US4939259A (en) * 1989-07-24 1990-07-03 Eli Lilly And Company 2-oxo-pyrido[2,3-g]quinoline derivatives
US6395744B1 (en) 1994-04-22 2002-05-28 Queen's University At Kingston Method and compositions for the treatment or amelioration of female sexual dysfunction
CA2334550A1 (en) * 1998-06-22 1999-12-29 Queen's University At Kingston Method and compositions for the treatment or amelioration of female sexual dysfunction

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198415A (en) * 1979-01-22 1980-04-15 Eli Lilly And Company Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines
FI852975L (fi) * 1984-08-03 1986-02-04 Lilly Co Eli Tricykliska kinolinderivat.
US4826986A (en) * 1986-06-16 1989-05-02 Eli Lilly And Company 6-Oxo-trans-octa- and decahydroquinolines

Also Published As

Publication number Publication date
DE3584205D1 (de) 1991-10-31
JPS6147487A (ja) 1986-03-07
GR851895B (es) 1985-12-03
EP0172697A3 (en) 1986-03-12
DK349185A (da) 1986-02-03
ES8800231A1 (es) 1987-10-16
IL75991A0 (en) 1985-12-31
JPH0670063B2 (ja) 1994-09-07
ES545859A0 (es) 1987-04-01
NZ212946A (en) 1988-07-28
KR860001815A (ko) 1986-03-22
IE58695B1 (en) 1993-11-03
ZA855830B (en) 1987-03-25
EP0172697A2 (en) 1986-02-26
SU1421258A3 (ru) 1988-08-30
ES551964A0 (es) 1987-10-16
PT80899A (en) 1985-09-01
ATE67766T1 (de) 1991-10-15
CA1292742C (en) 1991-12-03
AU4573785A (en) 1986-02-06
AR240822A1 (es) 1991-02-28
PT80899B (pt) 1987-12-30
KR880001430B1 (ko) 1988-08-08
PH22541A (en) 1988-10-17
HU193338B (en) 1987-09-28
DK349185D0 (da) 1985-08-01
AR240822A2 (es) 1991-02-28
AU569406B2 (en) 1988-01-28
EP0172697B1 (en) 1991-09-25
HUT38348A (en) 1986-05-28
IE851921L (en) 1986-02-02

Similar Documents

Publication Publication Date Title
NZ225362A (en) Optical isomers of medetomidine and pharmaceutical compositions
ES8603477A1 (es) Procedimiento para preparar una 1h-imidazo (4, 5-c) quinolin-4-amina
AU6844790A (en) Novel a-nor-steriod-3-carboxylic acid derivatives
NO900533D0 (no) Forbindelse for smoeremiddelsammensetninger, smoeremiddelsammensetning-konsentrat og fremgangsmaate for fremstilling av sammensetningen.
MY106202A (en) Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof.
ES8704177A1 (es) Un procedimiento para la preparacion de nuevas ocfidrotiazolo (4,5-g) guinolinas.
AU568920B2 (en) Pharmaceutical compositions of 3,4-dihydroisoquinolinium salts
ES2001794A6 (es) Un procedimiento para la preparacion de derivados de quinolina
AU5715190A (en) Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
ES2001703A6 (es) Procedimiento para la preparracion de derrrivados de acidos 2-(2-imidazolin -2-il)- piridin -3- carboxilicos.
NO163856C (no) Fremgangsmaate til fremstilling av ikke-toksiske salter av6-metyl-3,4-dihydro-1,2,3-oksatiazin-4-on-2,2-dioksyd.
IT1207498B (it) Procedimento per la preparazione di composizioni plasto-elastomeriche poliolefiniche, mediante vulcanizzazione dinamica.
ES8603184A1 (es) Metodo de preparar un derivado de acido b-carbolin-3-carbo- xilico
ES8800231A1 (es) Un procedimiento para la preparacion de una trans-octahidro-oxazolo 4,5-g quinolina
NZ214076A (en) 3-pyridinecarboxylate derivatives and herbicidal compositions
EP0228273A3 (en) Anti-oxidizing compounds, their production and use
ES8700650A1 (es) Procedimiento para preparar derivados de acidos 7-(ariloxi)-2-naftiloxi-alcancarboxilicos racemicos e isomeros
MY102059A (en) Naphthoxazines
ES8105712A1 (es) Un procedimiento para la preparacion de acido 1-etil-1,4-di-hidro-6-(2-naftil)-4-oxonicontinico y sus esteres
CA1264325C (en) AROYLIMIDAZOLONES
AU560656B2 (en) N-acyl-3-amino-1,2,3,4-tetrahydroquinolines
DE3461189D1 (en) New 3-alkylthio-2-o-carbamoyl-propane-1.2-diol-1-o-phosphocholines, and processes for their preparation
IT8419929A0 (it) Nuovi procedimenti per lapreparazione di composto conattivita' antiulcera.
PH21970A (en) Octahydropyrimido (4,5-g) quinoline derivatives as dopamine d-1 agonists
SU1241672A1 (ru) Эфиры н-гекс-2-енилянтарной кислоты в качестве основы синтетических смазочных масел

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612