FR2421171A1 - Procede de preparation de tetrahydrobenzoxocines et de cis-hexahydrodibenzopyranones - Google Patents

Procede de preparation de tetrahydrobenzoxocines et de cis-hexahydrodibenzopyranones

Info

Publication number
FR2421171A1
FR2421171A1 FR7907507A FR7907507A FR2421171A1 FR 2421171 A1 FR2421171 A1 FR 2421171A1 FR 7907507 A FR7907507 A FR 7907507A FR 7907507 A FR7907507 A FR 7907507A FR 2421171 A1 FR2421171 A1 FR 2421171A1
Authority
FR
France
Prior art keywords
tetrahydrobenzoxocins
hexahydrodibenzopyranones
cis
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7907507A
Other languages
English (en)
Other versions
FR2421171B1 (fr
Inventor
Charles Wilbur Ryan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2421171A1 publication Critical patent/FR2421171A1/fr
Application granted granted Critical
Publication of FR2421171B1 publication Critical patent/FR2421171B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings

Abstract

Le procédé consiste à faire réagir un résorcinol 5-substitué de formule :
FR7907507A 1978-03-31 1979-03-26 Procede de preparation de tetrahydrobenzoxocines et de cis-hexahydrodibenzopyranones Granted FR2421171A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/892,350 US4171315A (en) 1978-03-31 1978-03-31 Preparation of cis-hexahydrodibenzopyranones

Publications (2)

Publication Number Publication Date
FR2421171A1 true FR2421171A1 (fr) 1979-10-26
FR2421171B1 FR2421171B1 (fr) 1982-12-31

Family

ID=25399829

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7907507A Granted FR2421171A1 (fr) 1978-03-31 1979-03-26 Procede de preparation de tetrahydrobenzoxocines et de cis-hexahydrodibenzopyranones

Country Status (31)

Country Link
US (1) US4171315A (fr)
EP (1) EP0004753B1 (fr)
JP (1) JPS5927350B2 (fr)
AT (1) AT363469B (fr)
AU (1) AU516719B2 (fr)
BE (1) BE875089A (fr)
BG (2) BG32850A3 (fr)
CA (1) CA1132589A (fr)
CH (1) CH638198A5 (fr)
CS (2) CS208493B2 (fr)
DD (1) DD143612A5 (fr)
DE (1) DE2962942D1 (fr)
DK (1) DK132779A (fr)
EG (1) EG13932A (fr)
ES (1) ES479066A1 (fr)
FI (1) FI790981A (fr)
FR (1) FR2421171A1 (fr)
GB (1) GB2017703B (fr)
GR (1) GR71467B (fr)
HU (1) HU179972B (fr)
IE (1) IE48446B1 (fr)
IL (1) IL56944A (fr)
LU (1) LU81086A1 (fr)
MX (1) MX5532E (fr)
NZ (1) NZ189974A (fr)
PH (1) PH15168A (fr)
PL (2) PL117421B1 (fr)
PT (1) PT69384A (fr)
RO (1) RO78155A (fr)
YU (1) YU71279A (fr)
ZA (1) ZA791522B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4395560A (en) * 1982-05-24 1983-07-26 Eli Lilly And Company Preparation of 6a,10a-trans-hexahydrodibenzopyranones
ATE247097T1 (de) * 1998-05-04 2003-08-15 Univ Connecticut Analgetische und immunomodulierende cannabinoiden
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US7119108B1 (en) 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
US6900236B1 (en) * 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
MXPA02005103A (es) 1999-10-18 2003-09-25 Alexipharma Inc Ligandos selectivos del receptor de canabinoide (cb2) perifericos.
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US6943266B1 (en) * 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
JP2004532185A (ja) * 2001-01-26 2004-10-21 ユニバーシティ オブ コネチカット 新規なカンナビミメティックリガンド
US7173027B2 (en) 2001-01-29 2007-02-06 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
EP1414775B1 (fr) * 2001-07-13 2012-12-19 The University of Connecticut Cannabinoide bicyclique
EP1448557A4 (fr) * 2001-10-26 2005-02-02 Univ Connecticut Heteroindanes: nouvelle classe de ligands cannabimimetiques efficaces
JP2006511460A (ja) 2002-08-23 2006-04-06 ユニバーシティ オブ コネチカット 治療適応を持つケトカンナビノイド
JP2009510078A (ja) * 2005-09-29 2009-03-12 エーエムアール テクノロジー インコーポレイテッド Δ−９−テトラヒドロカンナビノールの生成法
CA2638940C (fr) * 2008-08-28 2009-09-15 Dalton Chemical Laboratories Inc. Synthese amelioree d'hexahydrodibenzopyranones

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054581A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones and intermediates therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582564A (en) * 1976-07-06 1981-01-14 Lilly Co Eli Dibenzopyrans
GB1579137A (en) * 1976-07-06 1980-11-12 Lilly Co Eli 5-isopropylidene-2,6-methano-3,4,5,6-tetrahydro-2h-1-benzoxocins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054581A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones and intermediates therefor

Also Published As

Publication number Publication date
RO78155A (fr) 1982-02-01
LU81086A1 (fr) 1979-06-19
FI790981A (fi) 1979-10-01
NZ189974A (en) 1980-10-08
ATA234679A (de) 1981-01-15
CH638198A5 (fr) 1983-09-15
EG13932A (en) 1983-03-31
PT69384A (en) 1979-04-01
BG32851A3 (en) 1982-10-15
CS208491B2 (en) 1981-09-15
PH15168A (en) 1982-08-31
HU179972B (en) 1983-01-28
IL56944A (en) 1982-08-31
GR71467B (fr) 1983-05-30
PL214573A1 (fr) 1980-03-10
AU4536179A (en) 1979-10-04
BE875089A (fr) 1979-09-26
YU71279A (en) 1982-10-31
IE791293L (en) 1979-09-30
EP0004753B1 (fr) 1982-05-26
PL123995B1 (en) 1982-12-31
DD143612A5 (de) 1980-09-03
GB2017703A (en) 1979-10-10
AU516719B2 (en) 1981-06-18
ES479066A1 (es) 1979-12-16
GB2017703B (en) 1982-10-06
PL117421B1 (en) 1981-08-31
US4171315A (en) 1979-10-16
EP0004753A1 (fr) 1979-10-17
JPS5927350B2 (ja) 1984-07-05
ZA791522B (en) 1980-11-26
JPS54132575A (en) 1979-10-15
AT363469B (de) 1981-08-10
DK132779A (da) 1979-10-01
MX5532E (es) 1983-09-23
BG32850A3 (en) 1982-10-15
CS208493B2 (en) 1981-09-15
FR2421171B1 (fr) 1982-12-31
IE48446B1 (en) 1985-01-23
CA1132589A (fr) 1982-09-28
IL56944A0 (en) 1979-05-31
DE2962942D1 (en) 1982-07-15

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Legal Events

Date Code Title Description
ST Notification of lapse