DE602004031678D1 - Verfahren zur herstellung von montelukast und salzen davon - Google Patents

Verfahren zur herstellung von montelukast und salzen davon

Info

Publication number
DE602004031678D1
DE602004031678D1 DE602004031678T DE602004031678T DE602004031678D1 DE 602004031678 D1 DE602004031678 D1 DE 602004031678D1 DE 602004031678 T DE602004031678 T DE 602004031678T DE 602004031678 T DE602004031678 T DE 602004031678T DE 602004031678 D1 DE602004031678 D1 DE 602004031678D1
Authority
DE
Germany
Prior art keywords
salts
montelucasts
producing
phenyl
ethenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004031678T
Other languages
English (en)
Inventor
Satyanarayana Chava
Seeta Ramanjaneyul Gorantla
Venkata Sunil Indukuri
Srinivas Simhadri
Vera Venkata Jammula
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Laboratories Ltd
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of DE602004031678D1 publication Critical patent/DE602004031678D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
DE602004031678T 2004-07-19 2004-07-19 Verfahren zur herstellung von montelukast und salzen davon Active DE602004031678D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2004/000212 WO2006008751A2 (en) 2004-07-19 2004-07-19 Process for the preparation of montelukast and its salts

Publications (1)

Publication Number Publication Date
DE602004031678D1 true DE602004031678D1 (de) 2011-04-14

Family

ID=35785612

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004031678T Active DE602004031678D1 (de) 2004-07-19 2004-07-19 Verfahren zur herstellung von montelukast und salzen davon

Country Status (5)

Country Link
US (2) US20090143590A1 (de)
EP (1) EP1812394B1 (de)
AT (1) ATE500225T1 (de)
DE (1) DE602004031678D1 (de)
WO (1) WO2006008751A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100815670B1 (ko) 2004-04-21 2008-03-20 테바 파마슈티컬 인더스트리즈 리미티드 몬테루카스트 나트륨을 제조하는 방법
ES2358923T3 (es) 2005-07-05 2011-05-16 Teva Pharmaceutical Industries, Ltd. Purificación de montelukast.
AR056815A1 (es) * 2005-11-18 2007-10-24 Synthon Bv PROCESO PARA PREPARAR MONTELUKAST, INTERMEDIARIOS DEL MISMO Y SUS SALES DE ADICIoN Y PROCEDIMIENTO DE PURIFICACIoN DE ÉSTOS Y DE MONTELUKAST
WO2007093873A1 (en) 2006-02-13 2007-08-23 Council Of Scientific And Industrial Research Bis-pyrr0l0[2,l-c] [1, 4] benzodiazepine- anthraquinone conjugates as antitumour agents and a process for the preparation thereof
JP2009529495A (ja) * 2006-02-21 2009-08-20 ケマジス・リミテッド モンテルカストアンモニウム塩の新規な多形体およびその調製方法
WO2007116240A1 (en) * 2006-04-12 2007-10-18 Glade Organics Private Limited An improved process for the manufacture of montelukast sodium
WO2008015703A2 (en) * 2006-08-04 2008-02-07 Matrix Laboratories Ltd Process for the preparation of montelukast and its salts thereof
EP1886998A1 (de) * 2006-08-09 2008-02-13 Esteve Quimica, S.A. Verfahren zur Reinigung von Montelukast und dessen Aminesalzen
WO2008023044A1 (en) * 2006-08-23 2008-02-28 Sandoz Ag Process for the preparation of montelukast free acid and its amine salts
US7700776B2 (en) * 2006-10-24 2010-04-20 Formosa Laboratories, Inc. Compounds and preparation for montelukast sodium
SI22382A (sl) * 2006-10-26 2008-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek za pripravo montelukasta
KR100774088B1 (ko) * 2006-12-14 2007-11-06 한미약품 주식회사 몬테루카스트의 제조방법 및 이에 사용되는 중간체
ES2320077B1 (es) * 2007-07-31 2010-02-26 Moehs Iberica, S.L. Proceso de preparacion de un antagonista de leucotrienos y de un intermedio del mismo.
WO2009027990A1 (en) * 2007-08-29 2009-03-05 Morepen Laboratories Limited Salts of montelukast and process therefor
ATE547513T1 (de) 2007-09-28 2012-03-15 Codexis Inc Ketoreduktase-polypeptide und verwendungen davon
EP2053043A1 (de) * 2007-10-26 2009-04-29 Inke, S.A. Montelukast-Kristallsalz
KR100920314B1 (ko) 2007-11-20 2009-10-08 보령제약 주식회사 몬테루카스트 신규한 염 및 그의 제조방법
CZ2008167A3 (cs) * 2008-03-14 2010-02-24 Zentiva, A. S. Specifické necistoty montelukastu
WO2009138993A1 (en) * 2008-05-13 2009-11-19 Macleods Pharmaceuticals Limited A process for preparation of montelukast sodium salt
WO2009144742A2 (en) 2008-05-26 2009-12-03 Aptuit Laurus Pvt Limited An improved process for preparing montelukast and salts thereof
KR101123292B1 (ko) 2008-09-26 2012-03-19 주식회사 엘지생명과학 몬테루카스트 나트륨염의 제조방법
KR100893756B1 (ko) * 2009-01-14 2009-04-22 주식회사 메디켐코리아 몬테루카스트의 효율적 제조방법
WO2011004298A1 (en) 2009-07-09 2011-01-13 Alembic Limited Montelukast hexamethylenediamine salt and its use for the preparation of montelukast sodium
EP2287154A1 (de) 2009-07-14 2011-02-23 KRKA, D.D., Novo Mesto Effiziente Synthese zur Herstellung von Montelukast
EP2552892A1 (de) 2010-03-31 2013-02-06 KRKA, D.D., Novo Mesto Effiziente synthese zur herstellung von montelukast und neue kristalline form von zwischenprodukten darin
HUP1000425A2 (en) 2010-08-11 2012-03-28 Richter Gedeon Nyrt Process for the production of montelukast sodium
CN102442947B (zh) * 2011-11-01 2013-10-16 上海璎黎科技有限公司 孟鲁司特钠中间体的制备方法
CN102442948B (zh) * 2011-11-01 2013-10-16 上海璎黎科技有限公司 孟鲁司特钠中间体的制备方法
WO2014001860A1 (en) 2012-05-18 2014-01-03 Laurus Labs Private Limited Process for preparation of montelukast sodium
JP6227963B2 (ja) * 2013-03-28 2017-11-08 株式会社トクヤマ モンテルカストジプロピルアミン塩の結晶を製造する方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE165088T1 (de) * 1990-10-12 1998-05-15 Merck Frosst Canada Inc Ungesättigte hydroxyalkylchinolinsäuren als leukotrien-antagonisten
TW448160B (en) * 1993-12-28 2001-08-01 Merck & Co Inc Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
US5523477A (en) * 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
AU2003209043A1 (en) * 2002-02-07 2003-09-02 Dr. Reddy's Laboratories Ltd. Novel anhydrous amorphous forms of montelukast sodium salt
US20050107612A1 (en) * 2002-12-30 2005-05-19 Dr. Reddy's Laboratories Limited Process for preparation of montelukast and its salts
ATE522507T1 (de) * 2003-10-10 2011-09-15 Synhton B V Montelukast in fester phase
ITMI20050247A1 (it) * 2005-02-18 2006-08-19 Chemi Spa Processo per la preparazione di montelukast

Also Published As

Publication number Publication date
WO2006008751A3 (en) 2006-10-26
ATE500225T1 (de) 2011-03-15
US20090143590A1 (en) 2009-06-04
EP1812394B1 (de) 2011-03-02
EP1812394A2 (de) 2007-08-01
US20110137039A1 (en) 2011-06-09
WO2006008751A2 (en) 2006-01-26

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