BG62810B1 - Метод за диастереоселективно получаване на нуклеозиднианалози - Google Patents

Метод за диастереоселективно получаване на нуклеозиднианалози Download PDF

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Publication number
BG62810B1
BG62810B1 BG100916A BG10091696A BG62810B1 BG 62810 B1 BG62810 B1 BG 62810B1 BG 100916 A BG100916 A BG 100916A BG 10091696 A BG10091696 A BG 10091696A BG 62810 B1 BG62810 B1 BG 62810B1
Authority
BG
Bulgaria
Prior art keywords
isomers
formula
formulas
group
mixture
Prior art date
Application number
BG100916A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG100916A (en
Inventor
Malcolm L. Hill
Andrew J. Whitehead
Roy Hornby
Peter Hallett
Michael D. Goodyear
P. O. Dwyer
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27267157&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG62810(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB9408103A external-priority patent/GB9408103D0/en
Priority claimed from GB9408091A external-priority patent/GB9408091D0/en
Priority claimed from GB9408112A external-priority patent/GB9408112D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of BG100916A publication Critical patent/BG100916A/xx
Publication of BG62810B1 publication Critical patent/BG62810B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Treatment Of Water By Oxidation Or Reduction (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG100916A 1994-04-23 1996-10-16 Метод за диастереоселективно получаване на нуклеозиднианалози BG62810B1 (bg)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9408103A GB9408103D0 (en) 1994-04-23 1994-04-23 Chemical compounds
GB9408091A GB9408091D0 (en) 1994-04-23 1994-04-23 Process
GB9408112A GB9408112D0 (en) 1994-04-23 1994-04-23 Process
PCT/EP1995/001503 WO1995029174A1 (en) 1994-04-23 1995-04-21 Process for the diastereoselective synthesis of nucleoside analogues

Publications (2)

Publication Number Publication Date
BG100916A BG100916A (en) 1997-07-31
BG62810B1 true BG62810B1 (bg) 2000-08-31

Family

ID=27267157

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100916A BG62810B1 (bg) 1994-04-23 1996-10-16 Метод за диастереоселективно получаване на нуклеозиднианалози

Country Status (30)

Country Link
US (2) US6051709A (el)
EP (1) EP0757684B1 (el)
JP (2) JP4056558B2 (el)
KR (1) KR100241842B1 (el)
CN (2) CN1151146C (el)
AP (1) AP704A (el)
AT (1) ATE181326T1 (el)
AU (1) AU696612B2 (el)
BG (1) BG62810B1 (el)
BR (1) BR9507499A (el)
CZ (1) CZ293827B6 (el)
DE (1) DE69510347T2 (el)
DK (1) DK0757684T3 (el)
EE (1) EE03442B1 (el)
ES (1) ES2133769T3 (el)
FI (1) FI120401B (el)
GR (1) GR3031043T3 (el)
HK (1) HK1004221A1 (el)
HU (1) HU218044B (el)
IL (1) IL113432A (el)
IS (1) IS1844B (el)
NO (2) NO307179B1 (el)
NZ (1) NZ285396A (el)
PL (1) PL180090B1 (el)
RO (2) RO117916B1 (el)
RU (1) RU2158736C2 (el)
SK (1) SK281327B6 (el)
TW (1) TW487704B (el)
UA (1) UA43362C2 (el)
WO (1) WO1995029174A1 (el)

Families Citing this family (42)

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US6175008B1 (en) * 1988-04-11 2001-01-16 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
IL113432A (en) * 1994-04-23 2000-11-21 Glaxo Group Ltd Process for the diastereoselective synthesis of nucleoside analogues
EP0869953A1 (en) * 1994-10-22 1998-10-14 Chong Kun Dang Corp Nucleoside derivatives and process for preparing thereof
GB9506644D0 (en) * 1995-03-31 1995-05-24 Wellcome Found Preparation of nucleoside analogues
US6113920A (en) * 1996-10-31 2000-09-05 Glaxo Wellcome Inc. Pharmaceutical compositions
RU2439069C2 (ru) * 1998-08-12 2012-01-10 Гайлид Сайенсиз, Инк. Способ получения 1,3-оксатиолановых нуклеозидов
GB9820417D0 (en) * 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
US6432966B2 (en) 1999-10-29 2002-08-13 Smithkline Beecham Corporation Antiviral combinations
CA2690137C (en) * 2001-03-01 2012-11-13 Gilead Sciences, Inc. Polymorphic and other crystalline forms of cis-ftc
US6600044B2 (en) 2001-06-18 2003-07-29 Brantford Chemicals Inc. Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers
WO2003027106A1 (en) * 2001-09-25 2003-04-03 Cadila Healthcar Limited Process for the preparation of crystalline polymorph ii of lamivudine
ITMI20030578A1 (it) * 2003-03-24 2004-09-25 Clariant Lsm Italia Spa Processo ed intermedi per la preparazione di emtricitabina
US20050187913A1 (en) 2003-05-06 2005-08-25 Yoram Nelken Web-based customer service interface
CN101307048B (zh) * 2007-05-18 2011-03-23 上海迪赛诺医药发展有限公司 立体选择性制备拉米夫定的方法
US20100190982A1 (en) * 2007-09-17 2010-07-29 Janardhana Rao Vascuri Process for the preparation of lamivudine form i
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
WO2009069013A1 (en) * 2007-11-29 2009-06-04 Ranbaxy Laboratories Limited Crystalline form i of lamivudine and its preparation
AU2008331167A1 (en) * 2007-11-29 2009-06-04 Ranbaxy Laboratories Limited Process and intermediates for the preparation of substituted 1, 3-oxathiolanes, especially lamivudine
WO2009069011A1 (en) 2007-11-29 2009-06-04 Ranbaxy Laboratories Limited Process for the preparation of substituted 1,3-oxathiolanes
WO2009084033A2 (en) * 2007-12-07 2009-07-09 Matrix Laboratories Limited Process for producing 5-fluoro-1-(2r,5s)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yi]cytosine
CN101391997B (zh) * 2008-09-18 2010-12-22 江苏科本医药化学有限公司 一种恩曲他滨中间体的合成方法
CN101362752B (zh) * 2008-09-18 2011-12-28 浙江教育学院 一种拉米夫定中间体的合成方法
WO2010082128A1 (en) 2009-01-19 2010-07-22 Aurobindo Pharma Limited Process for the preparation of cis-nucleoside derivative
KR101474570B1 (ko) 2009-04-13 2014-12-19 주식회사 대희화학 라미부딘의 신규한 중간체 및 이의 제조방법
CN101544632B (zh) * 2009-04-24 2011-09-07 湖南千金湘江药业股份有限公司 拉米夫定非对映选择合成方法
WO2011045815A2 (en) 2009-10-14 2011-04-21 Matrix Laboratories Ltd. Process for the preparation of lamivudine and novel salts in the manufacture thereof
KR20170078868A (ko) 2010-01-27 2017-07-07 비이브 헬쓰케어 컴퍼니 항바이러스 치료
US20120295930A1 (en) 2010-02-03 2012-11-22 Shankar Rama Novel process for the preparation of cis-nucleoside derivative
CN102167696B (zh) 2010-02-25 2013-09-18 南京正大天晴制药有限公司 拉米夫定草酸盐及其制备方法
EP2542551B1 (en) 2010-03-04 2014-08-27 Ranbaxy Laboratories Limited A process for stereoselective synthesis of 5-fluoro-1-(2r,5s)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
CN101830893A (zh) * 2010-05-31 2010-09-15 安徽一帆香料有限公司 一种拉米夫定中间体hdms的合成制备工艺
CN102399213A (zh) * 2010-09-08 2012-04-04 重庆医药工业研究院有限责任公司 拉米夫定单邻苯二甲酸盐及其合成方法
WO2012062835A1 (en) 2010-11-12 2012-05-18 Glaxo Wellcome Manufacturing Pte Ltd Novel pharmaceutical compositions
ES2729824T3 (es) 2011-04-08 2019-11-06 Laurus Labs Ltd Formas sólidas de compuestos antirretrovirales, procedimiento para la preparación y composición farmacéutica de los mismos
CN102796088B (zh) * 2012-05-21 2015-06-10 湖南千金湘江药业股份有限公司 一种拉米夫定的制备方法
CN103450166A (zh) * 2012-05-31 2013-12-18 上海迪赛诺药业有限公司 制备核苷化合物的方法
CN103864835A (zh) * 2013-03-26 2014-06-18 安徽贝克联合制药有限公司 一种提高拉米夫定中间体立体选择性制备方法
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
CN103694231A (zh) * 2013-11-28 2014-04-02 安徽一帆香料有限公司 一种拉米夫定中间体hdms的合成制备方法
US9571109B2 (en) * 2015-03-27 2017-02-14 International Business Machines Corporation Voltage controlled oscillator runaway prevention
CN106146481A (zh) * 2015-04-07 2016-11-23 江苏普信制药有限公司 一种核苷类似物的制备方法
CN105037340B (zh) * 2015-07-14 2018-08-10 福建广生堂药业股份有限公司 一种拉米夫定关键中间体手性异构体杂质的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6175008B1 (en) * 1988-04-11 2001-01-16 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5466806A (en) * 1989-02-08 1995-11-14 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
PT674634E (pt) * 1989-02-08 2003-09-30 Iaf Biochem Int Processos para preparar 1,3-oxatiolanos substituidos com propriedades antivirais
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
GB9009861D0 (en) * 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
DK0513917T4 (da) 1991-05-16 2001-06-25 Glaxo Group Ltd Antivirale kombinationer indeholdende nukleosidanaloger
GB9110874D0 (en) * 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
ZA923641B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
IL113432A (en) * 1994-04-23 2000-11-21 Glaxo Group Ltd Process for the diastereoselective synthesis of nucleoside analogues

Also Published As

Publication number Publication date
RU2158736C2 (ru) 2000-11-10
RO118714B1 (ro) 2003-09-30
BG100916A (en) 1997-07-31
SK281327B6 (sk) 2001-02-12
CN1149871A (zh) 1997-05-14
FI964251A0 (fi) 1996-10-22
HU9602925D0 (en) 1996-12-30
JPH10502615A (ja) 1998-03-10
UA43362C2 (uk) 2001-12-17
AP9600871A0 (en) 1996-10-31
ES2133769T3 (es) 1999-09-16
EP0757684B1 (en) 1999-06-16
IL113432A (en) 2000-11-21
TW487704B (en) 2002-05-21
HU218044B (hu) 2000-05-28
US6051709A (en) 2000-04-18
BR9507499A (pt) 1997-09-23
IS4366A (is) 1996-09-27
CN1290841C (zh) 2006-12-20
NO964487L (no) 1996-12-17
JP4056558B2 (ja) 2008-03-05
FI964251A (fi) 1996-10-22
CN1151146C (zh) 2004-05-26
HK1004221A1 (en) 1998-11-20
WO1995029174A1 (en) 1995-11-02
US6329522B1 (en) 2001-12-11
PL316904A1 (en) 1997-02-17
NO313096B1 (no) 2002-08-12
CZ293827B6 (cs) 2004-08-18
IS1844B (is) 2003-01-30
NZ285396A (en) 1998-10-28
KR100241842B1 (ko) 2000-03-02
IL113432A0 (en) 1995-07-31
PL180090B1 (pl) 2000-12-29
AP704A (en) 1998-12-04
NO307179B1 (no) 2000-02-21
EE9600134A (et) 1997-04-15
ATE181326T1 (de) 1999-07-15
FI120401B (fi) 2009-10-15
DE69510347D1 (de) 1999-07-22
DE69510347T2 (de) 1999-11-18
GR3031043T3 (en) 1999-12-31
NO995646L (no) 1999-11-17
RO117916B1 (ro) 2002-09-30
CN1500782A (zh) 2004-06-02
CZ309696A3 (en) 1997-04-16
NO995646D0 (no) 1999-11-17
NO964487D0 (no) 1996-10-22
EP0757684A1 (en) 1997-02-12
DK0757684T3 (da) 2000-01-17
SK135596A3 (en) 1997-07-09
EE03442B1 (et) 2001-06-15
AU696612B2 (en) 1998-09-17
JP2007217425A (ja) 2007-08-30
AU2447195A (en) 1995-11-16
HUT76296A (en) 1997-07-28

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