BG61768B1 - Инхибитори на 5-липоксигеназата - Google Patents

Инхибитори на 5-липоксигеназата Download PDF

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Publication number
BG61768B1
BG61768B1 BG100070A BG10007095A BG61768B1 BG 61768 B1 BG61768 B1 BG 61768B1 BG 100070 A BG100070 A BG 100070A BG 10007095 A BG10007095 A BG 10007095A BG 61768 B1 BG61768 B1 BG 61768B1
Authority
BG
Bulgaria
Prior art keywords
alkyl
pyran
compound
phenyl
methylimidazol
Prior art date
Application number
BG100070A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG100070A (bg
Inventor
Rodney W. Stevens
Takashi Mano
Kazunari Nakao
Yoshiyuki Okumura
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of BG100070A publication Critical patent/BG100070A/bg
Publication of BG61768B1 publication Critical patent/BG61768B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
BG100070A 1994-10-18 1995-10-18 Инхибитори на 5-липоксигеназата BG61768B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9401747 1994-10-18

Publications (2)

Publication Number Publication Date
BG100070A BG100070A (bg) 1996-05-31
BG61768B1 true BG61768B1 (bg) 1998-05-29

Family

ID=14098722

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100070A BG61768B1 (bg) 1994-10-18 1995-10-18 Инхибитори на 5-липоксигеназата

Country Status (31)

Country Link
EP (1) EP0787127B1 (cs)
JP (1) JP3032579B2 (cs)
CN (1) CN1093536C (cs)
AT (1) ATE198474T1 (cs)
AU (1) AU681520B2 (cs)
BG (1) BG61768B1 (cs)
CA (1) CA2202057C (cs)
CO (1) CO4480026A1 (cs)
CZ (1) CZ287350B6 (cs)
DE (1) DE69519804T2 (cs)
DK (1) DK0787127T3 (cs)
ES (1) ES2153033T3 (cs)
FI (1) FI971632A0 (cs)
GR (1) GR3035471T3 (cs)
HU (1) HU221543B (cs)
IL (1) IL115581A (cs)
LV (1) LV11468B (cs)
MY (1) MY114680A (cs)
NO (1) NO314629B1 (cs)
NZ (1) NZ285163A (cs)
PE (1) PE49196A1 (cs)
PL (1) PL180104B1 (cs)
RU (1) RU2136666C1 (cs)
SI (1) SI9500392A (cs)
SK (1) SK281577B6 (cs)
TR (1) TR199501274A2 (cs)
TW (1) TW411339B (cs)
UA (1) UA45312C2 (cs)
WO (1) WO1996011911A1 (cs)
YU (1) YU65995A (cs)
ZA (1) ZA958748B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239285B1 (en) 1998-02-06 2001-05-29 Pfizer Inc Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems
US6194585B1 (en) * 1998-12-22 2001-02-27 Pfizer Inc. Process for preparing 5-lipoxygenase inhibitors
US6346624B1 (en) * 1999-08-31 2002-02-12 Pfizer Inc Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems
US6344563B1 (en) * 1999-08-31 2002-02-05 Timothy Norris Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems
SG87145A1 (en) * 1999-08-31 2002-03-19 Pfizer Prod Inc Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems
CN1321112C (zh) 2000-03-24 2007-06-13 欧洲凯尔特股份有限公司 作为钠通道阻滞剂的芳基取代的吡唑、三唑和四唑化合物
DE60234822D1 (de) * 2001-04-20 2010-02-04 Novozymes As Lipoxygenase-varianten und ihre verwendung
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
CA2667566C (en) * 2006-11-27 2012-01-03 Pfizer Products Inc. Pyrazole analogs
AU2008331199A1 (en) * 2007-11-26 2009-06-04 Pfizer Inc. Pyrazole derivatives as 5-LO inhibitors
IN2014MN01839A (cs) * 2012-02-28 2015-07-03 Piramal Entpr Ltd
PT3762368T (pt) 2018-03-08 2022-05-06 Incyte Corp Compostos de aminopirazina diol como inibidores de pi3k-y
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0462830B1 (en) * 1990-06-21 1995-10-18 Zeneca Limited Cyclic ether derivatives
IE913866A1 (en) * 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
EP0505122A1 (en) * 1991-03-21 1992-09-23 Zeneca Limited Alpha, alpha-dialkylbenzyl derivatives
EP0540165A1 (en) * 1991-10-03 1993-05-05 Zeneca Limited Alkanoic acid derivatives
CN1050840C (zh) * 1993-06-14 2000-03-29 美国辉瑞有限公司 咪唑脂氧合酶抑制剂

Also Published As

Publication number Publication date
SI9500392A (en) 1996-08-31
SK128795A3 (en) 1996-07-03
LV11468B (en) 1996-12-20
DE69519804T2 (de) 2001-04-19
LV11468A (lv) 1996-08-20
PL319727A1 (en) 1997-08-18
ES2153033T3 (es) 2001-02-16
EP0787127B1 (en) 2001-01-03
NO971773D0 (no) 1997-04-17
SK281577B6 (sk) 2001-05-10
ZA958748B (en) 1997-04-17
PE49196A1 (es) 1996-11-21
UA45312C2 (uk) 2002-04-15
WO1996011911A1 (en) 1996-04-25
TW411339B (en) 2000-11-11
BG100070A (bg) 1996-05-31
NO314629B1 (no) 2003-04-22
NO971773L (no) 1997-06-17
JP3032579B2 (ja) 2000-04-17
NZ285163A (en) 1998-08-26
IL115581A0 (en) 1996-01-19
AU2417495A (en) 1996-05-06
AU681520B2 (en) 1997-08-28
DK0787127T3 (da) 2001-02-05
HUT77363A (hu) 1998-03-30
RU2136666C1 (ru) 1999-09-10
CN1093536C (zh) 2002-10-30
FI971632A (fi) 1997-04-17
HU221543B (hu) 2002-11-28
GR3035471T3 (en) 2001-05-31
CA2202057C (en) 2001-10-09
CZ117797A3 (cs) 1998-06-17
CO4480026A1 (es) 1997-07-09
JPH11507322A (ja) 1999-06-29
MY114680A (en) 2002-12-31
DE69519804D1 (de) 2001-02-08
ATE198474T1 (de) 2001-01-15
PL180104B1 (pl) 2000-12-29
EP0787127A1 (en) 1997-08-06
CZ287350B6 (en) 2000-10-11
FI971632A0 (fi) 1997-04-17
CA2202057A1 (en) 1996-04-25
YU65995A (sh) 1999-06-15
CN1169722A (zh) 1998-01-07
TR199501274A2 (tr) 1996-06-21
IL115581A (en) 1999-10-28

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