IL115581A - 5-Lipoxygenase inhibitors and pharmaceutical compositions thereof - Google Patents
5-Lipoxygenase inhibitors and pharmaceutical compositions thereofInfo
- Publication number
- IL115581A IL115581A IL11558195A IL11558195A IL115581A IL 115581 A IL115581 A IL 115581A IL 11558195 A IL11558195 A IL 11558195A IL 11558195 A IL11558195 A IL 11558195A IL 115581 A IL115581 A IL 115581A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- halo
- cyano
- alkylene
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9401747 | 1994-10-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL115581A0 IL115581A0 (en) | 1996-01-19 |
| IL115581A true IL115581A (en) | 1999-10-28 |
Family
ID=14098722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11558195A IL115581A (en) | 1994-10-18 | 1995-10-12 | 5-Lipoxygenase inhibitors and pharmaceutical compositions thereof |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0787127B1 (cs) |
| JP (1) | JP3032579B2 (cs) |
| CN (1) | CN1093536C (cs) |
| AT (1) | ATE198474T1 (cs) |
| AU (1) | AU681520B2 (cs) |
| BG (1) | BG61768B1 (cs) |
| CA (1) | CA2202057C (cs) |
| CO (1) | CO4480026A1 (cs) |
| CZ (1) | CZ287350B6 (cs) |
| DE (1) | DE69519804T2 (cs) |
| DK (1) | DK0787127T3 (cs) |
| ES (1) | ES2153033T3 (cs) |
| FI (1) | FI971632A (cs) |
| GR (1) | GR3035471T3 (cs) |
| HU (1) | HU221543B (cs) |
| IL (1) | IL115581A (cs) |
| LV (1) | LV11468B (cs) |
| MY (1) | MY114680A (cs) |
| NO (1) | NO314629B1 (cs) |
| NZ (1) | NZ285163A (cs) |
| PE (1) | PE49196A1 (cs) |
| PL (1) | PL180104B1 (cs) |
| RU (1) | RU2136666C1 (cs) |
| SI (1) | SI9500392A (cs) |
| SK (1) | SK281577B6 (cs) |
| TR (1) | TR199501274A2 (cs) |
| TW (1) | TW411339B (cs) |
| UA (1) | UA45312C2 (cs) |
| WO (1) | WO1996011911A1 (cs) |
| YU (1) | YU65995A (cs) |
| ZA (1) | ZA958748B (cs) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6239285B1 (en) | 1998-02-06 | 2001-05-29 | Pfizer Inc | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems |
| US6194585B1 (en) * | 1998-12-22 | 2001-02-27 | Pfizer Inc. | Process for preparing 5-lipoxygenase inhibitors |
| US6344563B1 (en) * | 1999-08-31 | 2002-02-05 | Timothy Norris | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems |
| SG87145A1 (en) * | 1999-08-31 | 2002-03-19 | Pfizer Prod Inc | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems |
| US6346624B1 (en) * | 1999-08-31 | 2002-02-12 | Pfizer Inc | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems |
| AU4589701A (en) * | 2000-03-24 | 2001-10-08 | Cocensys Inc | Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof |
| DK1383874T3 (da) * | 2001-04-20 | 2010-05-03 | Novozymes As | Varianter af lipogygenase og deres anvendelse |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| WO2008065493A1 (en) | 2006-11-27 | 2008-06-05 | Pfizer Products Inc. | Pyrazole analogs |
| KR20100072090A (ko) | 2007-11-26 | 2010-06-29 | 화이자 인코포레이티드 | 5-ｌｏ 억제제로서의 피라졸 유도체 |
| NZ631569A (en) * | 2012-02-28 | 2016-10-28 | Piramal Entpr Ltd | Phenyl alkanoic acid derivatives as gpr agonists |
| JP7268049B2 (ja) | 2018-03-08 | 2023-05-02 | インサイト・コーポレイション | ＰＩ３Ｋ－γ阻害剤としてのアミノピラジンジオール化合物 |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0462830B1 (en) * | 1990-06-21 | 1995-10-18 | Zeneca Limited | Cyclic ether derivatives |
| IE913866A1 (en) * | 1990-11-28 | 1992-06-03 | Ici Plc | Aryl derivatives |
| EP0505122A1 (en) * | 1991-03-21 | 1992-09-23 | Zeneca Limited | Alpha, alpha-dialkylbenzyl derivatives |
| EP0540165A1 (en) * | 1991-10-03 | 1993-05-05 | Zeneca Limited | Alkanoic acid derivatives |
| CN1050840C (zh) * | 1993-06-14 | 2000-03-29 | 美国辉瑞有限公司 | 咪唑脂氧合酶抑制剂 |
-
1994
- 1994-10-18 SK SK1287-95A patent/SK281577B6/sk unknown
-
1995
- 1995-05-29 PL PL95319727A patent/PL180104B1/pl not_active IP Right Cessation
- 1995-05-29 AU AU24174/95A patent/AU681520B2/en not_active Ceased
- 1995-05-29 AT AT95918121T patent/ATE198474T1/de not_active IP Right Cessation
- 1995-05-29 EP EP95918121A patent/EP0787127B1/en not_active Expired - Lifetime
- 1995-05-29 NZ NZ285163A patent/NZ285163A/en unknown
- 1995-05-29 HU HU9701853A patent/HU221543B/hu not_active IP Right Cessation
- 1995-05-29 JP JP8513058A patent/JP3032579B2/ja not_active Expired - Fee Related
- 1995-05-29 CA CA002202057A patent/CA2202057C/en not_active Expired - Fee Related
- 1995-05-29 ES ES95918121T patent/ES2153033T3/es not_active Expired - Lifetime
- 1995-05-29 DK DK95918121T patent/DK0787127T3/da active
- 1995-05-29 WO PCT/IB1995/000408 patent/WO1996011911A1/en active IP Right Grant
- 1995-05-29 RU RU97106099/04A patent/RU2136666C1/ru not_active IP Right Cessation
- 1995-05-29 CZ CZ19971177A patent/CZ287350B6/cs not_active IP Right Cessation
- 1995-05-29 DE DE69519804T patent/DE69519804T2/de not_active Expired - Fee Related
- 1995-05-29 CN CN95195926A patent/CN1093536C/zh not_active Expired - Fee Related
- 1995-09-12 TW TW084109522A patent/TW411339B/zh not_active IP Right Cessation
- 1995-10-02 CO CO95045652A patent/CO4480026A1/es unknown
- 1995-10-12 IL IL11558195A patent/IL115581A/xx not_active IP Right Cessation
- 1995-10-13 UA UA95104510A patent/UA45312C2/uk unknown
- 1995-10-16 MY MYPI95003103A patent/MY114680A/en unknown
- 1995-10-17 PE PE1995282113A patent/PE49196A1/es not_active Application Discontinuation
- 1995-10-17 ZA ZA958748A patent/ZA958748B/xx unknown
- 1995-10-17 YU YU65995A patent/YU65995A/sh unknown
- 1995-10-17 LV LVP-95-313A patent/LV11468B/en unknown
- 1995-10-17 SI SI9500392A patent/SI9500392A/sl unknown
- 1995-10-18 TR TR95/01274A patent/TR199501274A2/xx unknown
- 1995-10-18 BG BG100070A patent/BG61768B1/bg unknown
-
1997
- 1997-04-17 FI FI971632A patent/FI971632A/fi not_active IP Right Cessation
- 1997-04-17 NO NO19971773A patent/NO314629B1/no unknown
-
2001
- 2001-02-23 GR GR20010400310T patent/GR3035471T3/el not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GR3035471T3 (en) | 5-lipoxygenase inhibitors | |
| EP0629622A4 (cs) | ||
| FI70888C (fi) | Analogifoerfarande foer framstaellning av terapeutiskt anvaendbara n-(fenoxialkyl)imidazolderivat | |
| DE60017582D1 (de) | Tricyclische derivate der pyrazolcarbonsäure, ihre herstellung und sie enthaltende pharmazeutische zubereitungen | |
| NO913750L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske derivater. | |
| IL88901A (en) | Substituted 1,2,3-triazole, 1,2,4-triazole, pyrazole and pyrrole derivatives, their preparation and pharmaceutical compositions containing them | |
| KR920701167A (ko) | 약제학적 활성 화합물 | |
| MY128063A (en) | Aromatic heterocyclic compound as antiinflammatory agents | |
| CA2440222A1 (en) | Triazolopyridines as anti-inflammatory agents | |
| CA2379903A1 (en) | Novel benzotriazoles anti-inflammatory compounds | |
| CZ20013522A3 (cs) | Sloučeniny inhibující adhezi buněk vykazující protizánětlivé a imunosupresivní účinky | |
| WO1996039153A3 (en) | Use of di-beta-d-glucopyranosylamine compounds for controlling inflammatory reactions, and method of synthesis | |
| US4652582A (en) | Antiinflammatory-2-halo-4,5-diarylpyrroles | |
| RU97106099A (ru) | Ингибиторы 5-липоксигеназы | |
| MX9702814A (es) | Inhibidores de la 5-lipoxigenasa. | |
| CA2160140A1 (en) | Cycloalkylhydroxyureas and Their Use As Lipoxygenase Inhibitors | |
| WO2000071538A3 (en) | 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives | |
| CA2232267A1 (en) | Novel imidazole lipoxygenase inhibitors | |
| KR970707099A (ko) | 5-리폭시게나제 저해제(5-lipoxygenase inhibitors) | |
| EP0420086A3 (en) | Pyrimidoindole derivatives and processes for preparation thereof | |
| JO1814B1 (en) | Therapeutic agents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |