BG60934B2 - Терапевтични състави,съдържащи антрациклинови глюкозиди - Google Patents

Терапевтични състави,съдържащи антрациклинови глюкозиди Download PDF

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Publication number
BG60934B2
BG60934B2 BG098530A BG9853094A BG60934B2 BG 60934 B2 BG60934 B2 BG 60934B2 BG 098530 A BG098530 A BG 098530A BG 9853094 A BG9853094 A BG 9853094A BG 60934 B2 BG60934 B2 BG 60934B2
Authority
BG
Bulgaria
Prior art keywords
methyl
lyophilized
composition according
anthracycline
acids
Prior art date
Application number
BG098530A
Other languages
Bulgarian (bg)
English (en)
Inventor
Gaetano Gatti
Diego Oldani
Carlo Confalonieri
Luciano Gambini
Original Assignee
Pharmacia Italia S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia S.P.A. filed Critical Pharmacia Italia S.P.A.
Publication of BG60934B2 publication Critical patent/BG60934B2/bg

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG098530A 1984-10-22 1994-02-23 Терапевтични състави,съдържащи антрациклинови глюкозиди BG60934B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions

Publications (1)

Publication Number Publication Date
BG60934B2 true BG60934B2 (bg) 1996-06-28

Family

ID=10568553

Family Applications (1)

Application Number Title Priority Date Filing Date
BG098530A BG60934B2 (bg) 1984-10-22 1994-02-23 Терапевтични състави,съдържащи антрациклинови глюкозиди

Country Status (35)

Country Link
US (4) US4675311A (forum.php)
JP (1) JPH0611700B2 (forum.php)
KR (1) KR920005813B1 (forum.php)
CN (1) CN85107562B (forum.php)
AT (1) AT401345B (forum.php)
AU (1) AU572003B2 (forum.php)
BE (1) BE903484A (forum.php)
BG (1) BG60934B2 (forum.php)
CA (1) CA1248453A (forum.php)
CH (1) CH667594A5 (forum.php)
CS (1) CS270421B2 (forum.php)
DE (1) DE3536896C2 (forum.php)
DK (1) DK165620C (forum.php)
ES (1) ES8605374A1 (forum.php)
FI (2) FI853913A7 (forum.php)
FR (1) FR2571966B1 (forum.php)
GB (2) GB8426672D0 (forum.php)
GR (1) GR852549B (forum.php)
HK (1) HK94390A (forum.php)
HU (1) HU197988B (forum.php)
IE (1) IE56992B1 (forum.php)
IL (1) IL76732A (forum.php)
IT (1) IT1186779B (forum.php)
MY (1) MY103956A (forum.php)
NL (1) NL191308C (forum.php)
NO (1) NO170616C (forum.php)
NZ (1) NZ213885A (forum.php)
PH (1) PH23982A (forum.php)
PT (1) PT81347B (forum.php)
RU (2) RU1836088C (forum.php)
SE (1) SE467520B (forum.php)
SG (1) SG80290G (forum.php)
UA (2) UA34419C2 (forum.php)
YU (1) YU46160B (forum.php)
ZA (1) ZA858033B (forum.php)

Families Citing this family (34)

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US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
NO175802C (no) * 1986-12-05 1994-12-14 Erba Farmitalia Fremgangsmåte for fremstilling av en lagringsstabil antracyklinglycosidopplösning
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
CA2628857C (en) 1996-12-30 2011-09-13 Batelle Memorial Institute Formulation and method for treating neoplasms by inhalation
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
RU2292216C2 (ru) * 2000-10-31 2007-01-27 Фарма Мар, С.А. Кахалалид f
KR100970528B1 (ko) 2002-02-22 2010-07-16 쉐링 코포레이션 항신생물제, 특히 테모졸로마이드의 약제학적 제형, 이의제조 및 사용 방법
EP1474995B1 (en) * 2003-05-06 2012-11-14 Gumlink A/S A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product
DE04777189T1 (de) * 2003-07-02 2011-04-07 Solux Corporation, San Diego Thermisch stabiles kristallines epirubicin-hydrochlorid und herstellungsverfahren dafür
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
ATE471740T1 (de) * 2003-09-25 2010-07-15 Astellas Pharma Inc Antitumorales mittel mit einem histon-deacetylase-hemmer und einem topoisomerase-ii-hemmer
RU2262923C2 (ru) * 2003-12-25 2005-10-27 Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации Иммобилизованная форма доксорубицина
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
US20070004653A1 (en) * 2005-05-11 2007-01-04 Roberto Arosio Stable lyophilized anthracycline glycosides
EP2397034A1 (en) 2005-07-14 2011-12-21 Lithera, Inc. Sustained Release Enhanced Lipolytic Formulation for Regional Adipose Tissue Treatment
US9035032B2 (en) * 2005-12-13 2015-05-19 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
JP5634862B2 (ja) * 2007-05-16 2014-12-03 カーテーベー トゥモーアフォルシュングス ゲゼルシャフト ミット ベシュレンクテル ハフツング 低粘度アントラサイクリン製剤
ES2439497T3 (es) 2007-09-04 2014-01-23 Meiji Seika Pharma Co., Ltd. Preparación de una inyección, de una solución para inyección y de un kit de inyección
CA2703149A1 (en) * 2007-10-26 2009-04-30 Pfizer Products Inc. Idarubicin for the treatment of lymphoma in a dog
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
WO2011088413A2 (en) * 2010-01-15 2011-07-21 Lithera, Inc. Lyophilized cake formulations
GB2485885B (en) 2010-11-24 2015-06-17 Neothetics Inc Selective, lipophilic, and long-acting beta agonist monotherapeutic formulations and methods for the cosmetic treatment of adiposity and contour bulging
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
CA2894548C (en) 2012-12-13 2021-01-12 Cytrx Corporation Anthracycline formulations
US10278981B2 (en) 2013-06-05 2019-05-07 Cytrx Corporation Cytotoxic agents for the treatment of cancer

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YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
US4177264A (en) * 1977-10-17 1979-12-04 Sri International N-benzyl anthracyclines
GB2007645B (en) * 1977-10-17 1982-05-12 Stanford Res Inst Int Benzyl anthracyclines and pharmaceutical compositions containing them
JPS563851A (en) * 1979-06-22 1981-01-16 Matsushita Electric Works Ltd Fireplace in floor
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
US4325947A (en) * 1981-05-12 1982-04-20 Farmitalia Carlo Erba S.P.A. 4-Demethoxy-4'-deoxydoxorubicin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
FI75834C (fi) * 1982-05-24 1988-08-08 Erba Farmitalia Foerfarande foer framstaellning av antracyklinglykosidfoereningar.
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
CA1248944A (en) * 1982-09-28 1989-01-17 Gareth J. Thomas Anthracycline glycosides
JPS5982395A (ja) * 1982-11-02 1984-05-12 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
GR79729B (forum.php) * 1982-12-20 1984-10-31 Univ Ohio State Res Found
JPS6092212A (ja) * 1983-10-26 1985-05-23 Kyowa Hakko Kogyo Co Ltd ドキソルビシン塩の製剤
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same

Also Published As

Publication number Publication date
ES547578A0 (es) 1986-03-16
CS270421B2 (en) 1990-06-13
FI86252C (fi) 1992-08-10
UA34419C2 (uk) 2001-03-15
PH23982A (en) 1990-02-09
SE467520B (sv) 1992-08-03
BE903484A (fr) 1986-04-21
JPH0611700B2 (ja) 1994-02-16
CS756585A2 (en) 1989-11-14
NZ213885A (en) 1988-05-30
RU2101018C1 (ru) 1998-01-10
FI853913A7 (fi) 1986-04-23
NO170616B (no) 1992-08-03
SG80290G (en) 1990-11-23
FI854035A0 (fi) 1985-10-16
NL8502869A (nl) 1986-05-16
DK165620B (da) 1992-12-28
DK165620C (da) 1993-06-01
ES8605374A1 (es) 1986-03-16
GB2165751B (en) 1988-08-17
US5091372A (en) 1992-02-25
GB8525709D0 (en) 1985-11-20
HUT40759A (en) 1987-02-27
SE8504945D0 (sv) 1985-10-21
ATA303285A (de) 1996-01-15
FI853913A0 (fi) 1985-10-08
PT81347A (en) 1985-11-01
AU4880585A (en) 1986-05-01
AT401345B (de) 1996-08-26
IL76732A0 (en) 1986-02-28
GR852549B (forum.php) 1986-02-24
NL191308B (nl) 1994-12-16
NL191308C (nl) 1995-05-16
IL76732A (en) 1989-07-31
FI854035L (fi) 1986-04-23
NO170616C (no) 1992-11-11
RU1836088C (ru) 1993-08-23
NO854194L (no) 1986-04-23
DK481585A (da) 1986-04-23
AU572003B2 (en) 1988-04-28
UA19169A (uk) 1997-12-25
US4675311A (en) 1987-06-23
KR860003014A (ko) 1986-05-19
CN85107562A (zh) 1986-07-23
GB8426672D0 (en) 1984-11-28
YU46160B (sh) 1993-05-28
FI86252B (fi) 1992-04-30
DE3536896C2 (de) 1996-11-14
DK481585D0 (da) 1985-10-21
KR920005813B1 (ko) 1992-07-20
IE852593L (en) 1986-04-22
US4840938A (en) 1989-06-20
CN85107562B (zh) 1988-06-01
GB2165751A (en) 1986-04-23
IE56992B1 (en) 1992-02-26
FR2571966A1 (fr) 1986-04-25
JPS61246129A (ja) 1986-11-01
SE8504945L (sv) 1986-04-23
ZA858033B (en) 1986-06-25
CA1248453A (en) 1989-01-10
PT81347B (pt) 1987-11-11
CH667594A5 (de) 1988-10-31
YU164485A (en) 1987-10-31
FR2571966B1 (fr) 1988-04-15
IT1186779B (it) 1987-12-16
US5091373A (en) 1992-02-25
IT8522507A0 (it) 1985-10-16
MY103956A (en) 1993-10-30
HK94390A (en) 1990-11-23
DE3536896A1 (de) 1986-04-24
HU197988B (en) 1989-07-28

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