DK165620C - Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet - Google Patents

Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet

Info

Publication number
DK165620C
DK165620C DK481585A DK481585A DK165620C DK 165620 C DK165620 C DK 165620C DK 481585 A DK481585 A DK 481585A DK 481585 A DK481585 A DK 481585A DK 165620 C DK165620 C DK 165620C
Authority
DK
Denmark
Prior art keywords
preparation
anthracycliclycoside
annostation
cosolubilizing
freeze
Prior art date
Application number
DK481585A
Other languages
Danish (da)
English (en)
Other versions
DK481585D0 (da
DK165620B (da
DK481585A (da
Inventor
Gaetano Gatti
Diego Oldani
Carlo Confalonieri
Luciano Gambini
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of DK481585D0 publication Critical patent/DK481585D0/da
Publication of DK481585A publication Critical patent/DK481585A/da
Publication of DK165620B publication Critical patent/DK165620B/da
Application granted granted Critical
Publication of DK165620C publication Critical patent/DK165620C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK481585A 1984-10-22 1985-10-21 Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet DK165620C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8426672 1984-10-22
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions

Publications (4)

Publication Number Publication Date
DK481585D0 DK481585D0 (da) 1985-10-21
DK481585A DK481585A (da) 1986-04-23
DK165620B DK165620B (da) 1992-12-28
DK165620C true DK165620C (da) 1993-06-01

Family

ID=10568553

Family Applications (1)

Application Number Title Priority Date Filing Date
DK481585A DK165620C (da) 1984-10-22 1985-10-21 Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet

Country Status (35)

Country Link
US (4) US4675311A (forum.php)
JP (1) JPH0611700B2 (forum.php)
KR (1) KR920005813B1 (forum.php)
CN (1) CN85107562B (forum.php)
AT (1) AT401345B (forum.php)
AU (1) AU572003B2 (forum.php)
BE (1) BE903484A (forum.php)
BG (1) BG60934B2 (forum.php)
CA (1) CA1248453A (forum.php)
CH (1) CH667594A5 (forum.php)
CS (1) CS270421B2 (forum.php)
DE (1) DE3536896C2 (forum.php)
DK (1) DK165620C (forum.php)
ES (1) ES8605374A1 (forum.php)
FI (2) FI853913A7 (forum.php)
FR (1) FR2571966B1 (forum.php)
GB (2) GB8426672D0 (forum.php)
GR (1) GR852549B (forum.php)
HK (1) HK94390A (forum.php)
HU (1) HU197988B (forum.php)
IE (1) IE56992B1 (forum.php)
IL (1) IL76732A (forum.php)
IT (1) IT1186779B (forum.php)
MY (1) MY103956A (forum.php)
NL (1) NL191308C (forum.php)
NO (1) NO170616C (forum.php)
NZ (1) NZ213885A (forum.php)
PH (1) PH23982A (forum.php)
PT (1) PT81347B (forum.php)
RU (2) RU1836088C (forum.php)
SE (1) SE467520B (forum.php)
SG (1) SG80290G (forum.php)
UA (2) UA34419C2 (forum.php)
YU (1) YU46160B (forum.php)
ZA (1) ZA858033B (forum.php)

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JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
EP0954283B1 (en) 1996-12-30 2007-03-21 Battelle Memorial Institute Use of a non-encapsulated anticancer drug for the preparation of a formulation for treating neoplasms by inhalation
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
RU2292216C2 (ru) * 2000-10-31 2007-01-27 Фарма Мар, С.А. Кахалалид f
CN100346784C (zh) 2002-02-22 2007-11-07 先灵公司 抗肿瘤剂,特别是替莫唑胺的药物制剂,其制备方法和用途
EP1474995B1 (en) * 2003-05-06 2012-11-14 Gumlink A/S A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product
RU2341530C2 (ru) * 2003-07-02 2008-12-20 Солакс Корпорейшн Термостойкий кристаллический гидрохлорид эпирубицина и способ его получения
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
SI2263694T1 (sl) * 2003-09-25 2013-09-30 Astellas Pharma Inc. Antitumorsko sredstvo, ki obsega inhibitor histon-deacetilaze FK228 in inhibitor topoizomeraze II doksorubicin
RU2262923C2 (ru) * 2003-12-25 2005-10-27 Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации Иммобилизованная форма доксорубицина
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
TW200718426A (en) * 2005-05-11 2007-05-16 Sicor Inc Stable lyophilized anthracycline glycosides
PL1921919T3 (pl) 2005-07-14 2012-09-28 Lithera Inc Ulepszona lipolityczna formulacja o podtrzymywanym uwalnianiu do traktowania lokalnej tkanki tłuszczowej
WO2007070820A2 (en) * 2005-12-13 2007-06-21 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
CA2687291A1 (en) * 2007-05-16 2008-11-20 Ktb Tumorforschungsgesellschaft Mbh Low-viscous anthracycline formulation
CN101795694B (zh) 2007-09-04 2012-10-10 明治制果药业株式会社 注射剂、注射液和注射用试剂盒制剂
CN101835474A (zh) * 2007-10-26 2010-09-15 辉瑞产品公司 用于在狗中治疗淋巴瘤的伊达比星
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
MX2012008171A (es) * 2010-01-15 2012-12-17 Lithera Inc Formulaciones aglomeradas liofilizadas.
JP2013543897A (ja) 2010-11-24 2013-12-09 リセラ，インク． 脂肪症及び輪郭の膨れの美容処置のための、選択的な、親油性の、及び長時間作用性のベータアゴニストの単剤療法製剤、及び方法
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
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EP3915369A1 (en) 2012-12-13 2021-12-01 CytRx Corporation Anthracycline formulations
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Also Published As

Publication number Publication date
DK481585D0 (da) 1985-10-21
ZA858033B (en) 1986-06-25
FR2571966B1 (fr) 1988-04-15
BE903484A (fr) 1986-04-21
RU2101018C1 (ru) 1998-01-10
FI854035A0 (fi) 1985-10-16
IT1186779B (it) 1987-12-16
NL8502869A (nl) 1986-05-16
PT81347A (en) 1985-11-01
NZ213885A (en) 1988-05-30
IE852593L (en) 1986-04-22
SE8504945L (sv) 1986-04-23
NL191308B (nl) 1994-12-16
NO170616C (no) 1992-11-11
PH23982A (en) 1990-02-09
ATA303285A (de) 1996-01-15
SE467520B (sv) 1992-08-03
GB8525709D0 (en) 1985-11-20
GR852549B (forum.php) 1986-02-24
HUT40759A (en) 1987-02-27
GB8426672D0 (en) 1984-11-28
SE8504945D0 (sv) 1985-10-21
UA34419C2 (uk) 2001-03-15
ES8605374A1 (es) 1986-03-16
YU164485A (en) 1987-10-31
DE3536896C2 (de) 1996-11-14
MY103956A (en) 1993-10-30
BG60934B2 (bg) 1996-06-28
AT401345B (de) 1996-08-26
HK94390A (en) 1990-11-23
KR860003014A (ko) 1986-05-19
JPS61246129A (ja) 1986-11-01
DK165620B (da) 1992-12-28
DE3536896A1 (de) 1986-04-24
FI853913A7 (fi) 1986-04-23
IE56992B1 (en) 1992-02-26
YU46160B (sh) 1993-05-28
UA19169A (uk) 1997-12-25
JPH0611700B2 (ja) 1994-02-16
SG80290G (en) 1990-11-23
FI853913A0 (fi) 1985-10-08
HU197988B (en) 1989-07-28
NO170616B (no) 1992-08-03
US5091372A (en) 1992-02-25
US4840938A (en) 1989-06-20
GB2165751B (en) 1988-08-17
FI854035L (fi) 1986-04-23
GB2165751A (en) 1986-04-23
IT8522507A0 (it) 1985-10-16
US4675311A (en) 1987-06-23
AU4880585A (en) 1986-05-01
CN85107562B (zh) 1988-06-01
CH667594A5 (de) 1988-10-31
KR920005813B1 (ko) 1992-07-20
FR2571966A1 (fr) 1986-04-25
CA1248453A (en) 1989-01-10
US5091373A (en) 1992-02-25
FI86252C (fi) 1992-08-10
DK481585A (da) 1986-04-23
ES547578A0 (es) 1986-03-16
CS270421B2 (en) 1990-06-13
IL76732A (en) 1989-07-31
RU1836088C (ru) 1993-08-23
IL76732A0 (en) 1986-02-28
NO854194L (no) 1986-04-23
AU572003B2 (en) 1988-04-28
CN85107562A (zh) 1986-07-23
CS756585A2 (en) 1989-11-14
NL191308C (nl) 1995-05-16
FI86252B (fi) 1992-04-30
PT81347B (pt) 1987-11-11

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