NL191308C - Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside. - Google Patents

Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside.

Info

Publication number
NL191308C
NL191308C NL8502869A NL8502869A NL191308C NL 191308 C NL191308 C NL 191308C NL 8502869 A NL8502869 A NL 8502869A NL 8502869 A NL8502869 A NL 8502869A NL 191308 C NL191308 C NL 191308C
Authority
NL
Netherlands
Prior art keywords
solution
injectable
anthracycline glycoside
preparation
preparation containing
Prior art date
Application number
NL8502869A
Other languages
English (en)
Dutch (nl)
Other versions
NL8502869A (nl
NL191308B (nl
Inventor
Gaetano Gatti
Diego Oldani
Carlo Confalonieri
Luciano Gambini
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of NL8502869A publication Critical patent/NL8502869A/nl
Publication of NL191308B publication Critical patent/NL191308B/xx
Application granted granted Critical
Publication of NL191308C publication Critical patent/NL191308C/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL8502869A 1984-10-22 1985-10-21 Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside. NL191308C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8426672 1984-10-22
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions

Publications (3)

Publication Number Publication Date
NL8502869A NL8502869A (nl) 1986-05-16
NL191308B NL191308B (nl) 1994-12-16
NL191308C true NL191308C (nl) 1995-05-16

Family

ID=10568553

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8502869A NL191308C (nl) 1984-10-22 1985-10-21 Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside.

Country Status (35)

Country Link
US (4) US4675311A (forum.php)
JP (1) JPH0611700B2 (forum.php)
KR (1) KR920005813B1 (forum.php)
CN (1) CN85107562B (forum.php)
AT (1) AT401345B (forum.php)
AU (1) AU572003B2 (forum.php)
BE (1) BE903484A (forum.php)
BG (1) BG60934B2 (forum.php)
CA (1) CA1248453A (forum.php)
CH (1) CH667594A5 (forum.php)
CS (1) CS270421B2 (forum.php)
DE (1) DE3536896C2 (forum.php)
DK (1) DK165620C (forum.php)
ES (1) ES8605374A1 (forum.php)
FI (2) FI853913A7 (forum.php)
FR (1) FR2571966B1 (forum.php)
GB (2) GB8426672D0 (forum.php)
GR (1) GR852549B (forum.php)
HK (1) HK94390A (forum.php)
HU (1) HU197988B (forum.php)
IE (1) IE56992B1 (forum.php)
IL (1) IL76732A (forum.php)
IT (1) IT1186779B (forum.php)
MY (1) MY103956A (forum.php)
NL (1) NL191308C (forum.php)
NO (1) NO170616C (forum.php)
NZ (1) NZ213885A (forum.php)
PH (1) PH23982A (forum.php)
PT (1) PT81347B (forum.php)
RU (2) RU1836088C (forum.php)
SE (1) SE467520B (forum.php)
SG (1) SG80290G (forum.php)
UA (2) UA34419C2 (forum.php)
YU (1) YU46160B (forum.php)
ZA (1) ZA858033B (forum.php)

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US5977082A (en) 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
NO175802C (no) * 1986-12-05 1994-12-14 Erba Farmitalia Fremgangsmåte for fremstilling av en lagringsstabil antracyklinglycosidopplösning
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
CA2628857C (en) 1996-12-30 2011-09-13 Batelle Memorial Institute Formulation and method for treating neoplasms by inhalation
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
RU2292216C2 (ru) * 2000-10-31 2007-01-27 Фарма Мар, С.А. Кахалалид f
KR100970528B1 (ko) 2002-02-22 2010-07-16 쉐링 코포레이션 항신생물제, 특히 테모졸로마이드의 약제학적 제형, 이의제조 및 사용 방법
EP1474995B1 (en) * 2003-05-06 2012-11-14 Gumlink A/S A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product
DE04777189T1 (de) * 2003-07-02 2011-04-07 Solux Corporation, San Diego Thermisch stabiles kristallines epirubicin-hydrochlorid und herstellungsverfahren dafür
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
ATE471740T1 (de) * 2003-09-25 2010-07-15 Astellas Pharma Inc Antitumorales mittel mit einem histon-deacetylase-hemmer und einem topoisomerase-ii-hemmer
RU2262923C2 (ru) * 2003-12-25 2005-10-27 Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации Иммобилизованная форма доксорубицина
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
US20070004653A1 (en) * 2005-05-11 2007-01-04 Roberto Arosio Stable lyophilized anthracycline glycosides
EP2397034A1 (en) 2005-07-14 2011-12-21 Lithera, Inc. Sustained Release Enhanced Lipolytic Formulation for Regional Adipose Tissue Treatment
US9035032B2 (en) * 2005-12-13 2015-05-19 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
JP5634862B2 (ja) * 2007-05-16 2014-12-03 カーテーベー トゥモーアフォルシュングス ゲゼルシャフト ミット ベシュレンクテル ハフツング 低粘度アントラサイクリン製剤
ES2439497T3 (es) 2007-09-04 2014-01-23 Meiji Seika Pharma Co., Ltd. Preparación de una inyección, de una solución para inyección y de un kit de inyección
CA2703149A1 (en) * 2007-10-26 2009-04-30 Pfizer Products Inc. Idarubicin for the treatment of lymphoma in a dog
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
WO2011088413A2 (en) * 2010-01-15 2011-07-21 Lithera, Inc. Lyophilized cake formulations
GB2485885B (en) 2010-11-24 2015-06-17 Neothetics Inc Selective, lipophilic, and long-acting beta agonist monotherapeutic formulations and methods for the cosmetic treatment of adiposity and contour bulging
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
CA2894548C (en) 2012-12-13 2021-01-12 Cytrx Corporation Anthracycline formulations
US10278981B2 (en) 2013-06-05 2019-05-07 Cytrx Corporation Cytotoxic agents for the treatment of cancer

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IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
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Also Published As

Publication number Publication date
ES547578A0 (es) 1986-03-16
CS270421B2 (en) 1990-06-13
FI86252C (fi) 1992-08-10
UA34419C2 (uk) 2001-03-15
PH23982A (en) 1990-02-09
SE467520B (sv) 1992-08-03
BE903484A (fr) 1986-04-21
JPH0611700B2 (ja) 1994-02-16
CS756585A2 (en) 1989-11-14
BG60934B2 (bg) 1996-06-28
NZ213885A (en) 1988-05-30
RU2101018C1 (ru) 1998-01-10
FI853913A7 (fi) 1986-04-23
NO170616B (no) 1992-08-03
SG80290G (en) 1990-11-23
FI854035A0 (fi) 1985-10-16
NL8502869A (nl) 1986-05-16
DK165620B (da) 1992-12-28
DK165620C (da) 1993-06-01
ES8605374A1 (es) 1986-03-16
GB2165751B (en) 1988-08-17
US5091372A (en) 1992-02-25
GB8525709D0 (en) 1985-11-20
HUT40759A (en) 1987-02-27
SE8504945D0 (sv) 1985-10-21
ATA303285A (de) 1996-01-15
FI853913A0 (fi) 1985-10-08
PT81347A (en) 1985-11-01
AU4880585A (en) 1986-05-01
AT401345B (de) 1996-08-26
IL76732A0 (en) 1986-02-28
GR852549B (forum.php) 1986-02-24
NL191308B (nl) 1994-12-16
IL76732A (en) 1989-07-31
FI854035L (fi) 1986-04-23
NO170616C (no) 1992-11-11
RU1836088C (ru) 1993-08-23
NO854194L (no) 1986-04-23
DK481585A (da) 1986-04-23
AU572003B2 (en) 1988-04-28
UA19169A (uk) 1997-12-25
US4675311A (en) 1987-06-23
KR860003014A (ko) 1986-05-19
CN85107562A (zh) 1986-07-23
GB8426672D0 (en) 1984-11-28
YU46160B (sh) 1993-05-28
FI86252B (fi) 1992-04-30
DE3536896C2 (de) 1996-11-14
DK481585D0 (da) 1985-10-21
KR920005813B1 (ko) 1992-07-20
IE852593L (en) 1986-04-22
US4840938A (en) 1989-06-20
CN85107562B (zh) 1988-06-01
GB2165751A (en) 1986-04-23
IE56992B1 (en) 1992-02-26
FR2571966A1 (fr) 1986-04-25
JPS61246129A (ja) 1986-11-01
SE8504945L (sv) 1986-04-23
ZA858033B (en) 1986-06-25
CA1248453A (en) 1989-01-10
PT81347B (pt) 1987-11-11
CH667594A5 (de) 1988-10-31
YU164485A (en) 1987-10-31
FR2571966B1 (fr) 1988-04-15
IT1186779B (it) 1987-12-16
US5091373A (en) 1992-02-25
IT8522507A0 (it) 1985-10-16
MY103956A (en) 1993-10-30
HK94390A (en) 1990-11-23
DE3536896A1 (de) 1986-04-24
HU197988B (en) 1989-07-28

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SNR Assignments of patents or rights arising from examined patent applications

Owner name: PHARMACIA S.P.A.

TNT Modifications of names of proprietors of patents or applicants of examined patent applications

Owner name: PHARMACIA & UPJOHN S.P.A.

TNT Modifications of names of proprietors of patents or applicants of examined patent applications

Owner name: PHARMACIA ITALIA S.P.A.

V4 Discontinued because of reaching the maximum lifetime of a patent

Effective date: 20051021