BRPI0605832A2 - glicosìdeos de antraciclina liofilizados estáveis - Google Patents
glicosìdeos de antraciclina liofilizados estáveisInfo
- Publication number
- BRPI0605832A2 BRPI0605832A2 BRPI0605832-9A BRPI0605832A BRPI0605832A2 BR PI0605832 A2 BRPI0605832 A2 BR PI0605832A2 BR PI0605832 A BRPI0605832 A BR PI0605832A BR PI0605832 A2 BRPI0605832 A2 BR PI0605832A2
- Authority
- BR
- Brazil
- Prior art keywords
- dried
- hydrochloride
- anthracycline
- stable
- anthracycline glycoside
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
GLICOSìDEOS DE ANTRACICLINA LIOFILIZADOS ESTáVEIS. A presente invenção fornece sais glicosídeos de antraciclina liofilizados e sais glicosídeos de antraciclina liofilizados estáveis, especialmente o sal hidrocloreto. Além disso, a presente invenção proporciona métodos para estabilizar esses sais glicosídeos de antraciclina e métodos para produzir sais glicosídeos de antraciclina liofilizados estáveis corno, por exemplo, o composto antineoplástico hidrocíoret~o de idarubicina, ou os compostos hidrocloreto de doxorubicina e hidrocloreto de epirubicina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68013905P | 2005-05-11 | 2005-05-11 | |
PCT/US2006/018434 WO2006122309A2 (en) | 2005-05-11 | 2006-05-11 | Stable lyophilized anthracycline glycosides |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0605832A2 true BRPI0605832A2 (pt) | 2009-05-26 |
Family
ID=37397341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0605832-9A BRPI0605832A2 (pt) | 2005-05-11 | 2006-05-11 | glicosìdeos de antraciclina liofilizados estáveis |
Country Status (9)
Country | Link |
---|---|
US (1) | US20070004653A1 (pt) |
EP (1) | EP1814525A2 (pt) |
JP (1) | JP2008513519A (pt) |
KR (1) | KR20070088447A (pt) |
BR (1) | BRPI0605832A2 (pt) |
CA (1) | CA2606390A1 (pt) |
MX (1) | MX2007000413A (pt) |
TW (1) | TW200718426A (pt) |
WO (1) | WO2006122309A2 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ563365A (en) * | 2005-06-02 | 2011-02-25 | Schering Corp | Combination of HCV protease inhibitors with a surfactant |
US8119602B2 (en) * | 2005-06-02 | 2012-02-21 | Schering Corporation | Administration of HCV protease inhibitors in combination with food to improve bioavailability |
WO2009118754A2 (en) * | 2008-03-28 | 2009-10-01 | Astron Research Limited | A process for preparing a stable lyophilized composition |
DE102011103751A1 (de) * | 2011-05-31 | 2012-12-06 | Heraeus Precious Metals Gmbh & Co. Kg | Kristallisierung von Epirubicinhydrochlorid |
CN102614118B (zh) * | 2012-03-15 | 2014-04-30 | 北京协和药厂 | 注射用盐酸表柔比星制剂的制备方法及制剂 |
CN103087124B (zh) * | 2012-11-21 | 2016-01-13 | 浙江海正药业股份有限公司 | 一种制备阿霉素的方法 |
US20150087681A1 (en) * | 2013-09-25 | 2015-03-26 | Pranav Patel | Bendamustine HCL Stable Lyophilized Formulations |
CN104861014B (zh) * | 2015-06-03 | 2017-09-29 | 道中道(菏泽)制药有限公司 | 一种盐酸表阿霉素结晶的制备方法 |
CN110483301A (zh) * | 2018-06-11 | 2019-11-22 | 上海睿升化工科技有限公司 | 一种2-氧代戊烷-1,5-二甲酸二乙酯的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4012284A (en) * | 1962-11-16 | 1977-03-15 | Societa' Farmaceutici Italia, S.p.A. | Process of preparation of antibiotic F.I. 1762 derivatives |
YU33730B (en) * | 1967-04-18 | 1978-02-28 | Farmaceutici Italia | Process for preparing a novel antibiotic substance and salts thereof |
GB8426672D0 (en) * | 1984-10-22 | 1984-11-28 | Erba Farmitalia | Pharmaceutical compositions |
GB8519452D0 (en) * | 1985-08-02 | 1985-09-11 | Erba Farmitalia | Injectable solutions |
BE1000540A5 (fr) * | 1986-12-05 | 1989-01-24 | Erba Carlo Spa | Solutions injectables pretes a l'emploi contenant un agent antitumeur du type anthracycline-glucoside. |
FI883338A (fi) * | 1987-07-16 | 1989-01-17 | Bristol Myers Co | Vattenloesningar av doxorubicinhydroklorid. |
JP2603480B2 (ja) * | 1987-08-05 | 1997-04-23 | 住友製薬株式会社 | 安定化されたアンスラサイクリン系製剤 |
GB9200247D0 (en) * | 1992-01-07 | 1992-02-26 | Erba Carlo Spa | Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation |
GB9926843D0 (en) * | 1999-11-12 | 2000-01-12 | Pharmacia & Upjohn Spa | Lipid complex of alkycyclines |
JP4594736B2 (ja) * | 2002-11-29 | 2010-12-08 | 大日本住友製薬株式会社 | 安定化されたアンスラサイクリン系化合物の凍結乾燥製剤 |
US7485707B2 (en) * | 2003-07-02 | 2009-02-03 | Solux Corporation | Thermally stable crystalline epirubicin hydrochloride and method of making the same |
-
2006
- 2006-05-11 US US11/433,026 patent/US20070004653A1/en not_active Abandoned
- 2006-05-11 WO PCT/US2006/018434 patent/WO2006122309A2/en active Application Filing
- 2006-05-11 KR KR1020077000683A patent/KR20070088447A/ko not_active Application Discontinuation
- 2006-05-11 BR BRPI0605832-9A patent/BRPI0605832A2/pt not_active IP Right Cessation
- 2006-05-11 MX MX2007000413A patent/MX2007000413A/es not_active Application Discontinuation
- 2006-05-11 TW TW095116825A patent/TW200718426A/zh unknown
- 2006-05-11 JP JP2007532702A patent/JP2008513519A/ja active Pending
- 2006-05-11 EP EP06759672A patent/EP1814525A2/en not_active Withdrawn
- 2006-05-11 CA CA002606390A patent/CA2606390A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
TW200718426A (en) | 2007-05-16 |
WO2006122309A3 (en) | 2007-06-28 |
US20070004653A1 (en) | 2007-01-04 |
WO2006122309A2 (en) | 2006-11-16 |
JP2008513519A (ja) | 2008-05-01 |
KR20070088447A (ko) | 2007-08-29 |
EP1814525A2 (en) | 2007-08-08 |
MX2007000413A (es) | 2007-06-15 |
WO2006122309B1 (en) | 2007-09-07 |
CA2606390A1 (en) | 2006-11-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 3A, 4A, 5A E 6A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012. |