|
ZA859574B
(en)
*
|
1984-12-21 |
1986-08-27 |
Hoffmann La Roche |
Process for the manufacture of oxetanones
|
|
CA1270837A
(en)
*
|
1984-12-21 |
1990-06-26 |
Hoffmann-La Roche Limited |
Oxetanones
|
|
CA1328881C
(en)
*
|
1984-12-21 |
1994-04-26 |
Pierre Barbier |
Process for the manufacture of oxetanones
|
|
JPH0618793Y2
(ja)
*
|
1986-06-13 |
1994-05-18 |
パイオニア株式会社 |
作業台
|
|
US4806564A
(en)
*
|
1987-05-26 |
1989-02-21 |
Merck & Co., Inc. |
Antihypercholesterolemic beta-lactones
|
|
US4816477A
(en)
*
|
1987-05-26 |
1989-03-28 |
Merck & Co., Inc. |
Antihypercholesterolemic β-lactones
|
|
US5484777A
(en)
*
|
1989-04-20 |
1996-01-16 |
Lange, Iii; Louis G. |
Pancreatic cholesterol esterase inhibitor
|
|
US5063210A
(en)
*
|
1989-04-20 |
1991-11-05 |
Lange Iii Louis G |
Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption
|
|
US5017565A
(en)
*
|
1989-04-20 |
1991-05-21 |
Lange Iii Louis G |
Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase
|
|
JP2960947B2
(ja)
*
|
1989-12-25 |
1999-10-12 |
日清製粉株式会社 |
脂質分解酵素阻害剤
|
|
US5376640A
(en)
*
|
1989-12-25 |
1994-12-27 |
Nisshin Flour Milling Co., Ltd. |
Lipolytic enzyme inhibitors
|
|
CA2098167C
(en)
*
|
1992-06-24 |
2006-12-19 |
Dorothea Isler |
Foodstuffs and feedstuffs containing a lipase inhibitor
|
|
CA2128044C
(en)
*
|
1993-08-05 |
2007-02-20 |
Klaus-Dieter Bremer |
Pharmaceutical compositions comprising a glucosidase and/or amylase inhibitor, and a lipase inhibitor
|
|
US6268392B1
(en)
|
1994-09-13 |
2001-07-31 |
G. D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
|
|
US6262277B1
(en)
|
1994-09-13 |
2001-07-17 |
G.D. Searle And Company |
Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
|
|
US6642268B2
(en)
|
1994-09-13 |
2003-11-04 |
G.D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
|
|
MY116591A
(en)
*
|
1996-04-26 |
2004-02-28 |
Hoffmann La Roche |
Process for the production of lipstatin and tetrahydrolipstatin
|
|
HU230834B1
(hu)
*
|
1997-02-05 |
2018-07-30 |
F.Hoffmann-La Roche Ag |
Tetrahidrolipsztatin felhasználása
|
|
US6004996A
(en)
*
|
1997-02-05 |
1999-12-21 |
Hoffman-La Roche Inc. |
Tetrahydrolipstatin containing compositions
|
|
US7344713B1
(en)
*
|
1997-07-07 |
2008-03-18 |
Pimentel Julio L |
Decreased fat absorption with an anti-lipase antibody
|
|
GB9727131D0
(en)
*
|
1997-12-24 |
1998-02-25 |
Knoll Ag |
Therapeutic agents
|
|
RU2234917C2
(ru)
*
|
1997-12-24 |
2004-08-27 |
Кнолль Акциенгезелльшафт |
Терапевтические средства
|
|
US6299868B1
(en)
|
1999-07-14 |
2001-10-09 |
Geltex Pharmaceuticals, Inc. |
Fat-binding polymers
|
|
US7048917B1
(en)
|
1998-01-09 |
2006-05-23 |
Genzyme Corporation |
Fat-binding polymers
|
|
US6264937B1
(en)
*
|
1998-01-09 |
2001-07-24 |
Geltex Pharmaceuticals, Inc. |
Fat-binding polymers
|
|
CA2340052C
(en)
*
|
1998-08-14 |
2007-05-29 |
F. Hoffmann-La Roche Ag |
Pharmaceutical compositions containing lipase inhibitors and chitosan
|
|
DK1105122T3
(da)
|
1998-08-14 |
2005-08-08 |
Hoffmann La Roche |
Pharmaceutical compositions containing lipase inhibitors
|
|
US6462091B1
(en)
|
1998-12-23 |
2002-10-08 |
G.D. Searle & Co. |
Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
|
|
US6562860B1
(en)
|
1998-12-23 |
2003-05-13 |
G. D. Searle & Co. |
Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications
|
|
US6489366B1
(en)
|
1998-12-23 |
2002-12-03 |
G. D. Searle, Llc |
Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
|
|
CZ20012341A3
(cs)
|
1998-12-23 |
2001-12-12 |
G. D. Searle Llc Corparate Patent Department |
Kombinace inhibitorů transferoního proteinu cholesterylesterů a derivátů kyseliny fibrové pro kardiovaskulární indikace
|
|
PL348508A1
(en)
|
1998-12-23 |
2002-05-20 |
Searle Llc |
Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
|
|
ES2200588T3
(es)
|
1998-12-23 |
2004-03-01 |
G.D. Searle Llc |
Combinacion de inhibidores del transporte de oxido biliar ileal y de derivados de acido fibrico para indicaciones cardiovasculares.
|
|
ATE242008T1
(de)
|
1998-12-23 |
2003-06-15 |
Searle Llc |
Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen
|
|
ATE228118T1
(de)
*
|
1999-01-29 |
2002-12-15 |
Hoffmann La Roche |
Reinigung von lipstatin
|
|
HK1046092A1
(zh)
*
|
1999-07-14 |
2002-12-27 |
Genzyme Corporation |
可與脂解酶抑制劑任意配合的脂肪結合聚合物
|
|
AR025587A1
(es)
*
|
1999-09-13 |
2002-12-04 |
Hoffmann La Roche |
Formulaciones en dispersion que contienen inhibidores de lipasa
|
|
AR025609A1
(es)
|
1999-09-13 |
2002-12-04 |
Hoffmann La Roche |
Formulaciones lipidas solidas
|
|
EP1132389A1
(en)
|
2000-03-06 |
2001-09-12 |
Vernalis Research Limited |
New aza-indolyl derivatives for the treatment of obesity
|
|
JP2003528830A
(ja)
|
2000-03-10 |
2003-09-30 |
ファルマシア・コーポレーション |
テトラヒドロベンゾチエピン類の製造方法
|
|
EP1142572A1
(de)
*
|
2000-04-04 |
2001-10-10 |
Volker Dr. Helmstädter |
Oxetanon-enthaltende Präparate zur Behandlung von Darmerkrankungen
|
|
DE10021618A1
(de)
*
|
2000-05-04 |
2001-11-15 |
Volker Helmstaedter |
Präparat für Darmerkrankungen und dessen Verwendung
|
|
ATE334662T1
(de)
*
|
2000-06-27 |
2006-08-15 |
Hoffmann La Roche |
Herstellungsverfahren von arzneizubereitungen
|
|
SI1307264T1
(en)
*
|
2000-07-28 |
2005-02-28 |
F. Hoffmann-La Roche Ag |
New pharmaceutical composition
|
|
DK1307263T3
(da)
*
|
2000-07-28 |
2005-08-22 |
Hoffmann La Roche |
Hidtil ukendt anvendelse af lipaseinhibitorer
|
|
CN1323661C
(zh)
*
|
2000-08-09 |
2007-07-04 |
霍夫曼-拉罗奇有限公司 |
脂酶抑制剂的用途
|
|
US6900226B2
(en)
*
|
2000-09-06 |
2005-05-31 |
Hoffman-La Roche Inc. |
Neuropeptide Y antagonists
|
|
AU2002221670B2
(en)
|
2000-10-16 |
2006-11-02 |
F. Hoffmann-La Roche Ag |
Indoline derivatives and their use as 5-HT2 receptor ligands
|
|
GB0030710D0
(en)
*
|
2000-12-15 |
2001-01-31 |
Hoffmann La Roche |
Piperazine derivatives
|
|
EP1347979B1
(en)
|
2000-12-27 |
2007-08-08 |
F. Hoffmann-La Roche Ag |
Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands
|
|
GB0106177D0
(en)
*
|
2001-03-13 |
2001-05-02 |
Hoffmann La Roche |
Piperazine derivatives
|
|
US20030072804A1
(en)
*
|
2001-03-19 |
2003-04-17 |
The Procter & Gamble Company |
Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body
|
|
US20030091610A1
(en)
*
|
2001-03-19 |
2003-05-15 |
The Procter & Gamble Company |
Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body
|
|
KR100621287B1
(ko)
|
2001-05-21 |
2006-09-13 |
에프. 호프만-라 로슈 아게 |
신경 펩타이드 y 수용체에 대한 리간드로서의 퀴놀린유도체
|
|
US6730319B2
(en)
|
2001-06-06 |
2004-05-04 |
Hoffmann-La Roche Inc. |
Pharmaceutical compositions having depressed melting points
|
|
US20030027786A1
(en)
*
|
2001-06-06 |
2003-02-06 |
Karsten Maeder |
Lipase inhibiting composition
|
|
US7041280B2
(en)
*
|
2001-06-29 |
2006-05-09 |
Genzyme Corporation |
Aryl boronate functionalized polymers for treating obesity
|
|
US7049345B2
(en)
|
2001-06-29 |
2006-05-23 |
Genzyme Corporation |
Fat-binding polymers
|
|
EP1446125B1
(en)
*
|
2001-08-30 |
2009-04-29 |
Alizyme Therapeutics Limited |
Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity
|
|
US6787558B2
(en)
|
2001-09-28 |
2004-09-07 |
Hoffmann-La Roche Inc. |
Quinoline derivatives
|
|
US11207805B2
(en)
|
2001-10-12 |
2021-12-28 |
Aquestive Therapeutics, Inc. |
Process for manufacturing a resulting pharmaceutical film
|
|
US7357891B2
(en)
|
2001-10-12 |
2008-04-15 |
Monosol Rx, Llc |
Process for making an ingestible film
|
|
US20190328679A1
(en)
|
2001-10-12 |
2019-10-31 |
Aquestive Therapeutics, Inc. |
Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
|
|
US8765167B2
(en)
|
2001-10-12 |
2014-07-01 |
Monosol Rx, Llc |
Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
|
|
US8900498B2
(en)
|
2001-10-12 |
2014-12-02 |
Monosol Rx, Llc |
Process for manufacturing a resulting multi-layer pharmaceutical film
|
|
US10285910B2
(en)
|
2001-10-12 |
2019-05-14 |
Aquestive Therapeutics, Inc. |
Sublingual and buccal film compositions
|
|
US20110033542A1
(en)
|
2009-08-07 |
2011-02-10 |
Monosol Rx, Llc |
Sublingual and buccal film compositions
|
|
US8900497B2
(en)
|
2001-10-12 |
2014-12-02 |
Monosol Rx, Llc |
Process for making a film having a substantially uniform distribution of components
|
|
US20070281003A1
(en)
|
2001-10-12 |
2007-12-06 |
Fuisz Richard C |
Polymer-Based Films and Drug Delivery Systems Made Therefrom
|
|
US8603514B2
(en)
|
2002-04-11 |
2013-12-10 |
Monosol Rx, Llc |
Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
|
|
GB0125659D0
(en)
*
|
2001-10-25 |
2001-12-19 |
Ssl Int Plc |
Spermicides
|
|
WO2003040127A1
(en)
|
2001-11-02 |
2003-05-15 |
G.D. Searle Llc |
Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake
|
|
AU2002359601A1
(en)
|
2001-12-04 |
2003-06-17 |
Biogal Gyogyszergyar Rt |
A fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth
|
|
IL162323A0
(en)
|
2001-12-04 |
2005-11-20 |
Biogal Pharmaceutical Co |
Preparation of orlistat and orlistat crystalline forms
|
|
BR0215080A
(pt)
|
2001-12-20 |
2004-10-05 |
Osi Pharm Inc |
Composto inibidores de lipase pancreática, sua sìntese e uso
|
|
MXPA04006255A
(es)
|
2002-01-17 |
2004-09-27 |
Pharmacia Corp |
Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato.
|
|
GB0202015D0
(en)
*
|
2002-01-29 |
2002-03-13 |
Hoffmann La Roche |
Piperazine Derivatives
|
|
ES2304498T3
(es)
*
|
2002-02-04 |
2008-10-16 |
F. Hoffmann-La Roche Ag |
Derivados de quinolina como antagonistas de npy.
|
|
WO2003072577A1
(en)
*
|
2002-02-28 |
2003-09-04 |
F.Hoffmann-La Roche Ag |
Thiazole derivatives as npy receptor antagonists
|
|
WO2003088975A1
(en)
*
|
2002-04-17 |
2003-10-30 |
The Burnham Institute |
Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
|
|
US7728153B2
(en)
|
2002-04-17 |
2010-06-01 |
The Burnham Institute For Medical Research |
Method for the asymmetric synthesis of beta-lactone compounds
|
|
ATE453390T1
(de)
*
|
2002-04-26 |
2010-01-15 |
Hoffmann La Roche |
Pharmazeutische zusammensetzung enthaltend einen lipase - inhibitor und glucomannan
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
EP1560816A1
(en)
*
|
2002-07-05 |
2005-08-10 |
F. Hoffmann-La Roche Ag |
Quinazoline derivatives
|
|
RU2324685C2
(ru)
*
|
2002-08-07 |
2008-05-20 |
Ф.Хоффманн-Ля Рош Аг |
Производные тиазола, способ их получения и применение, фармацевтическая композиция, обладающая свойствами антагонистов рецепторов npy
|
|
PT1539746E
(pt)
*
|
2002-09-12 |
2007-02-28 |
Hoffmann La Roche |
Compostos de ácido 1h-indol-5-propiónico, substituído em n, como agonistas de ppar (receptores activados dos proliferadores de peroxissoma), úteis para o tratamento de diabetes
|
|
ATE405560T1
(de)
*
|
2002-11-25 |
2008-09-15 |
Hoffmann La Roche |
Indolderivaten
|
|
US8372430B2
(en)
*
|
2002-12-17 |
2013-02-12 |
The Procter & Gamble Company |
Compositions, methods, and kits useful for the alleviation of gastrointestinal effects
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
US20040178058A1
(en)
*
|
2003-03-10 |
2004-09-16 |
Hsueh-Chung Chen |
Electro-chemical deposition apparatus and method of preventing cavities in an ECD copper film
|
|
EP1457206A1
(en)
*
|
2003-03-13 |
2004-09-15 |
Fournier Laboratories Ireland Limited |
Combined use of a fibrate and orlistat for the treatment of obesity
|
|
EP1658283A2
(en)
*
|
2003-05-30 |
2006-05-24 |
Ranbaxy Laboratories, Ltd. |
Substituted pyrrole derivatives and their use as hmg-co inhibitors
|
|
WO2004113314A1
(en)
*
|
2003-06-23 |
2004-12-29 |
Biocon Limited |
Novel boronate esters
|
|
GB0314967D0
(en)
*
|
2003-06-26 |
2003-07-30 |
Hoffmann La Roche |
Piperazine derivatives
|
|
US20060025337A1
(en)
*
|
2003-07-01 |
2006-02-02 |
President And Fellows Of Harvard College |
Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
|
|
AU2003253254A1
(en)
*
|
2003-07-17 |
2005-02-04 |
Biocon Limited |
Preparation of tetrahydrolipstatin by hydrogenation of lipstatin, solvent extraction and purification
|
|
RU2321586C2
(ru)
*
|
2003-08-12 |
2008-04-10 |
Ф.Хоффманн-Ля Рош Аг |
Производные тиазола в качестве антагонистов npy
|
|
EP1658288B1
(en)
*
|
2003-08-12 |
2007-12-05 |
F. Hoffmann-La Roche Ag |
2-amino-5-benzoylthiazole npy antagonists
|
|
US20050239859A2
(en)
*
|
2003-09-03 |
2005-10-27 |
Solvay Pharmaceuticals Gmbh |
Novel medical uses of 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity
|
|
US7547693B2
(en)
|
2003-09-22 |
2009-06-16 |
Banyu Pharmaceutical Co. Ltd. |
Piperidine derivative
|
|
US20050124660A1
(en)
*
|
2003-10-27 |
2005-06-09 |
Jochen Antel |
Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds
|
|
US20050143441A1
(en)
*
|
2003-10-27 |
2005-06-30 |
Jochen Antel |
Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity
|
|
BRPI0416639A
(pt)
|
2003-11-19 |
2007-01-16 |
Metabasis Therapeutics Inc |
tiromiméticos contendo fósforo
|
|
US8017634B2
(en)
|
2003-12-29 |
2011-09-13 |
President And Fellows Of Harvard College |
Compositions for treating obesity and insulin resistance disorders
|
|
US20050171027A1
(en)
*
|
2003-12-29 |
2005-08-04 |
President And Fellows Of Harvard College |
Compositions for treating or preventing obesity and insulin resistance disorders
|
|
PL209905B1
(pl)
*
|
2004-01-15 |
2011-11-30 |
Bringwell Internat Ab |
Preparat do leczenia otyłości i związanego z nią syndromu metabolicznego
|
|
KR20060124679A
(ko)
|
2004-01-16 |
2006-12-05 |
후지 세이유 가부시키가이샤 |
리파아제 저해제
|
|
US7074822B2
(en)
|
2004-02-23 |
2006-07-11 |
Solvay Pharmaceuticals Gmbh |
Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
|
|
EP2305352A1
(en)
|
2004-04-02 |
2011-04-06 |
Merck Sharp & Dohme Corp. |
5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders
|
|
EP3263118B1
(en)
|
2004-05-10 |
2019-09-25 |
University of Copenhagen |
Flaxseeds for body weight management
|
|
US7879866B2
(en)
*
|
2004-07-19 |
2011-02-01 |
Dorte Xenia Gram |
Inhibition of the activity of the capsaicin receptor in the treatment of obesity or obesity-related diseases and disorders
|
|
CA2585175A1
(en)
|
2004-10-25 |
2006-05-04 |
Solvay Pharmaceuticals Gmbh |
Pharmaceutical compositions comprising cb1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type i, obesity and related conditions
|
|
ATE439347T1
(de)
*
|
2004-11-23 |
2009-08-15 |
Warner Lambert Co |
7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure- derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia
|
|
US20060246141A1
(en)
*
|
2005-04-12 |
2006-11-02 |
Elan Pharma International, Limited |
Nanoparticulate lipase inhibitor formulations
|
|
AU2006243243B2
(en)
*
|
2005-05-03 |
2009-05-14 |
F. Hoffmann-La Roche Ag |
Tetracyclic azapyrazinoindolines as 5-HT2 ligands
|
|
JP5154927B2
(ja)
|
2005-05-30 |
2013-02-27 |
Msd株式会社 |
新規ピペリジン誘導体
|
|
WO2006138418A2
(en)
*
|
2005-06-14 |
2006-12-28 |
President And Fellows Of Harvard College |
Improvement of cognitive performance with sirtuin activators
|
|
US20070149466A1
(en)
*
|
2005-07-07 |
2007-06-28 |
Michael Milburn |
Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
|
|
WO2007018248A1
(ja)
|
2005-08-10 |
2007-02-15 |
Banyu Pharmaceutical Co., Ltd. |
ピリドン化合物
|
|
CA2618568A1
(en)
*
|
2005-08-18 |
2007-02-22 |
F. Hoffmann-La Roche Ag |
Thiazolyl piperidine derivatives useful as h3 receptor modulators
|
|
DE602006017712D1
(de)
|
2005-08-24 |
2010-12-02 |
Banyu Pharma Co Ltd |
Phenylpyridonderivat
|
|
CA2621470A1
(en)
|
2005-09-07 |
2007-03-15 |
Banyu Pharmaceutical Co., Ltd. |
Bicyclic aromatic substituted pyridone derivative
|
|
US7355055B2
(en)
*
|
2005-09-08 |
2008-04-08 |
Reliance Life Sciences Pvt. Ltd. |
Compounds for treatment of lipase-mediated diseases
|
|
US7741317B2
(en)
|
2005-10-21 |
2010-06-22 |
Bristol-Myers Squibb Company |
LXR modulators
|
|
KR20080059233A
(ko)
|
2005-10-21 |
2008-06-26 |
노파르티스 아게 |
레닌 억제제, 및 항이상지질혈증제 및/또는 항비만제의조합물
|
|
AU2006307046A1
(en)
|
2005-10-27 |
2007-05-03 |
Msd K.K. |
Novel benzoxathiin derivative
|
|
AU2006313430B2
(en)
*
|
2005-11-08 |
2012-09-06 |
Ranbaxy Laboratories Limited |
Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
|
|
AU2006312557B2
(en)
|
2005-11-10 |
2011-12-08 |
Msd K.K. |
Aza-substituted spiro derivative
|
|
US7888376B2
(en)
|
2005-11-23 |
2011-02-15 |
Bristol-Myers Squibb Company |
Heterocyclic CETP inhibitors
|
|
EP1968967B1
(en)
*
|
2005-11-30 |
2011-04-27 |
F. Hoffmann-La Roche AG |
1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators
|
|
ES2359739T3
(es)
*
|
2005-11-30 |
2011-05-26 |
F. Hoffmann-La Roche Ag |
Derivados de indol-2-il-amida 1,5-sustituida.
|
|
AU2006319235A1
(en)
*
|
2005-11-30 |
2007-06-07 |
F. Hoffmann-La Roche Ag |
5-substituted indole-2-carboxamide derivatives
|
|
JP2009518351A
(ja)
*
|
2005-12-09 |
2009-05-07 |
エフ.ホフマン−ラ ロシュ アーゲー |
肥満症の処置に有用な三環性アミド誘導体
|
|
ATE449776T1
(de)
*
|
2005-12-15 |
2009-12-15 |
Hoffmann La Roche |
Pyrroloä2,3-cüpyridinderivate
|
|
JP2009519293A
(ja)
*
|
2005-12-16 |
2009-05-14 |
エフ.ホフマン−ラ ロシュ アーゲー |
H3レセプター調節剤としてのピロロ[2,3−b]ピリジン誘導体
|
|
SK22006A3
(sk)
*
|
2006-01-03 |
2007-08-02 |
Biotika, A. S. |
Kmeň Streptomyces toxytricini produkujúci lipstatín a príprava lipstatínu s uvedeným kmeňom
|
|
US20080021092A1
(en)
*
|
2006-01-06 |
2008-01-24 |
Deepak Murpani |
Stable pharmaceutical compositions of orlistat
|
|
CA2635719A1
(en)
*
|
2006-01-13 |
2007-07-19 |
F. Hoffmann-La Roche Ag |
Cyclohexyl piperazinyl methanone derivatives and their use as histamine h3 receptor modulators
|
|
DE602007008831D1
(de)
*
|
2006-01-23 |
2010-10-14 |
Hoffmann La Roche |
Cyclohexyl-sulfonamid-derivate mit h3-rezeptoraktivität
|
|
WO2008020314A2
(en)
*
|
2006-03-14 |
2008-02-21 |
Ranbaxy Laboratories Limited |
Statin stabilizing dosage formulations
|
|
KR101252635B1
(ko)
|
2006-04-20 |
2013-04-10 |
(주)아모레퍼시픽 |
리파아제 저해제 및 친유성 오일흡수제를 포함하는 약학조성물 및 이로부터 제조된 경구 투여용 제제
|
|
US7432255B2
(en)
*
|
2006-05-16 |
2008-10-07 |
Hoffmann-La Roche Inc. |
1H-indol-5-yl-piperazin-1-yl-methanone derivatives
|
|
JP2009538859A
(ja)
*
|
2006-05-30 |
2009-11-12 |
エフ.ホフマン−ラ ロシュ アーゲー |
ピペリジニルピリミジン誘導体
|
|
MX2009000439A
(es)
*
|
2006-07-14 |
2009-02-04 |
Ranbaxy Lab Ltd |
Formas polimorficas de un inhibidor de hmg-coa reductasa y usos de las mismas.
|
|
US7514433B2
(en)
|
2006-08-03 |
2009-04-07 |
Hoffmann-La Roche Inc. |
1H-indole-6-yl-piperazin-1-yl-methanone derivatives
|
|
JPWO2008038692A1
(ja)
|
2006-09-28 |
2010-01-28 |
萬有製薬株式会社 |
ジアリールケチミン誘導体
|
|
AR063275A1
(es)
*
|
2006-10-12 |
2009-01-14 |
Epix Delaware Inc |
Compuestos de carboxamida, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la activacion de ccr2.
|
|
US8404896B2
(en)
|
2006-12-01 |
2013-03-26 |
Bristol-Myers Squibb Company |
N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
|
|
US20080146559A1
(en)
|
2006-12-08 |
2008-06-19 |
Li Chen |
4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
|
|
US20080200422A1
(en)
*
|
2007-01-09 |
2008-08-21 |
Cavener Douglas R |
Methods for reduction of adipose tissue mass
|
|
CA2682727C
(en)
|
2007-04-02 |
2016-03-22 |
Banyu Pharmaceutical Co., Ltd. |
Indoledione derivative
|
|
AP2009005026A0
(en)
*
|
2007-04-09 |
2009-12-31 |
Scidose Llc |
Combinations of statins and anti-obesity agent
|
|
US20080249156A1
(en)
*
|
2007-04-09 |
2008-10-09 |
Palepu Nageswara R |
Combinations of statins and anti-obesity agent and glitazones
|
|
EP2166843A4
(en)
|
2007-06-01 |
2010-08-11 |
Univ Princeton |
TREATMENT OF VIRUS INFECTIONS BY MODULATION OF HOST CELL METABOLISMS
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
CA2688161C
(en)
|
2007-06-04 |
2020-10-20 |
Kunwar Shailubhai |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
KR101504777B1
(ko)
*
|
2007-06-06 |
2015-03-20 |
랜박시 래보러터리스 리미티드 |
오르리스타트의 제조 방법
|
|
EP2190303A1
(en)
*
|
2007-09-12 |
2010-06-02 |
Københavns Universitet |
Compositions and methods for increasing the suppression of hunger and reducing the digestibility of non-fat energy satiety
|
|
BRPI0817053A2
(pt)
*
|
2007-09-17 |
2015-03-24 |
Reddys Lab Ltd Dr |
Formulações farmacêuticas de orlistat
|
|
WO2009044380A2
(en)
|
2007-10-05 |
2009-04-09 |
Ranbaxy Laboratories Limited |
Formulations containing orlistat particles having controlled particle size
|
|
EP2219614A1
(en)
*
|
2007-10-15 |
2010-08-25 |
Inventis DDS Pvt Limited |
Pharmaceutical composition of orlistat
|
|
US8298583B2
(en)
|
2007-10-19 |
2012-10-30 |
Monosol Rx, Llc |
Film delivery system for tetrahydrolipstatin
|
|
WO2009076512A1
(en)
|
2007-12-11 |
2009-06-18 |
Epix Delaware, Inc. |
Carboxamidξ compounds and their use as chemokine receptor agonists
|
|
US20090214682A1
(en)
*
|
2008-02-22 |
2009-08-27 |
Heuer Marvin A |
Composition and methods for weight loss in a subject
|
|
WO2009110510A1
(ja)
|
2008-03-06 |
2009-09-11 |
萬有製薬株式会社 |
アルキルアミノピリジン誘導体
|
|
EP2268822B1
(en)
|
2008-03-26 |
2019-08-28 |
Biocon Limited |
Improved fermentation process for higher yield coefficient of lipase-inhibitor with respect to consumed fatty acid
|
|
CA2717384A1
(en)
|
2008-03-28 |
2009-10-01 |
Banyu Pharmaceutical Co., Ltd. |
Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
|
|
EP2810951B1
(en)
|
2008-06-04 |
2017-03-15 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
US20110071129A1
(en)
|
2008-06-19 |
2011-03-24 |
Makoto Ando |
Spirodiamine-diaryl ketoxime derivative
|
|
EP2141236A1
(en)
*
|
2008-07-03 |
2010-01-06 |
KRKA, D.D., Novo Mesto |
Process for production of lipstatin and microorganisms therefore
|
|
ES2624828T3
(es)
|
2008-07-16 |
2017-07-17 |
Synergy Pharmaceuticals Inc. |
Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
|
|
JPWO2010013595A1
(ja)
|
2008-07-30 |
2012-01-12 |
Msd株式会社 |
5員−5員又は5員−6員縮環シクロアルキルアミン誘導体
|
|
WO2010039019A1
(es)
|
2008-10-03 |
2010-04-08 |
Sigma Alimentos, S.A. De C.V. |
Composición para promover el control de colesterol total y ldl y/o la pérdida de peso y/o la termogénesis
|
|
US8309107B2
(en)
*
|
2008-10-06 |
2012-11-13 |
Banner Pharmacaps, Inc. |
Stable solutions of orlistat for pharmaceutical dosage forms
|
|
WO2010043592A1
(en)
*
|
2008-10-15 |
2010-04-22 |
Revotar Biopharmaceuticals Ag |
Lipase inhibitors for use for the treatment of obesity
|
|
AU2009307884B2
(en)
|
2008-10-22 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
US8329914B2
(en)
|
2008-10-31 |
2012-12-11 |
Merck Sharp & Dohme Corp |
Cyclic benzimidazole derivatives useful as anti-diabetic agents
|
|
WO2010093601A1
(en)
|
2009-02-10 |
2010-08-19 |
Metabasis Therapeutics, Inc. |
Novel sulfonic acid-containing thyromimetics, and methods for their use
|
|
EP2395987A1
(en)
|
2009-02-12 |
2011-12-21 |
Coöperatieve Mirzorg U.A., Arnhem |
Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders
|
|
US20100215635A1
(en)
*
|
2009-02-23 |
2010-08-26 |
Zoltan Kiss |
Small molecules to induce weight loss or to reduce weight gain
|
|
WO2010112569A1
(en)
|
2009-03-31 |
2010-10-07 |
Robert Zimmermann |
Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
|
|
US8993509B2
(en)
|
2009-03-31 |
2015-03-31 |
Robert Zimmerman |
Method for treatment of cachexia by administering inhibitors of adipose triglyceride lipase expression or activity
|
|
BRPI0901602B8
(pt)
|
2009-04-03 |
2021-05-25 |
Ems S/A |
formulação farmacêuticas
|
|
RU2412713C2
(ru)
*
|
2009-05-14 |
2011-02-27 |
Открытое Акционерное Общество Завод Экологической Техники И Экопитания "Диод" |
Фармацевтическая композиция, биологически активная добавка и способ уменьшения поглощения жира из пищи
|
|
WO2011028309A1
(en)
|
2009-09-04 |
2011-03-10 |
University Of Toledo |
PROCESSES FOR PRODUCING OPTICALLY PURE β-LACTONES FROM ALDEHYDES AND COMPOSITIONS PRODUCED THEREBY
|
|
ES2527179T3
(es)
|
2009-11-02 |
2015-01-21 |
Pfizer Inc. |
Derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol
|
|
UA107369C2
(en)
|
2010-02-01 |
2014-12-25 |
Lab Bago S A |
Pharmaceutical composition with anti-obesity activity comprising a premixture of pure orlistat and preparation process
|
|
US8524909B2
(en)
|
2010-02-02 |
2013-09-03 |
Hoffmann-La Roche Inc. |
Tetrahydro-pyran derivatives
|
|
RU2441654C2
(ru)
*
|
2010-02-17 |
2012-02-10 |
Лабораториос Баго С.А. |
Фармацевтическая композиция с активностью против ожирения, включающая премикс чистого орлистата, и способ ее изготовления
|
|
US8895596B2
(en)
|
2010-02-25 |
2014-11-25 |
Merck Sharp & Dohme Corp |
Cyclic benzimidazole derivatives useful as anti-diabetic agents
|
|
US8450350B2
(en)
|
2010-05-05 |
2013-05-28 |
Infinity Pharmaceuticals, Inc. |
Triazoles as inhibitors of fatty acid synthase
|
|
EP3159331A1
(en)
|
2010-05-05 |
2017-04-26 |
Infinity Pharmaceuticals, Inc. |
Tetrazolones as inhibitors of fatty acid synthase
|
|
JP2013528172A
(ja)
|
2010-05-21 |
2013-07-08 |
ファイザー・インク |
2−フェニルベンゾイルアミド
|
|
WO2011149416A1
(en)
|
2010-05-24 |
2011-12-01 |
Swedish Oat Fiber Ab |
Aqueous dispersion comprising galactolipids and method for production thereof
|
|
EP2392327A1
(en)
|
2010-06-04 |
2011-12-07 |
Universitätsmedizin der Johannes Gutenberg-Universität Mainz |
Use of orlistat for the anti-parasitic treatment of a parasitic disease
|
|
CA2802832A1
(en)
|
2010-07-06 |
2012-01-12 |
Astrazeneca Ab |
Therapeutic agents 976
|
|
CN101885713B
(zh)
*
|
2010-07-19 |
2011-11-30 |
大邦(湖南)生物制药有限公司 |
一种毒三素链霉菌发酵液中分离提取利普司他汀的工艺
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
CN101948450B
(zh)
*
|
2010-10-13 |
2013-04-24 |
鲁南制药集团股份有限公司 |
一种生产制备奥利司他的方法
|
|
US9149959B2
(en)
|
2010-10-22 |
2015-10-06 |
Monosol Rx, Llc |
Manufacturing of small film strips
|
|
PL3400944T3
(pl)
|
2010-11-04 |
2020-11-16 |
Albireo Ab |
Inhibitory ibat w leczeniu chorób wątroby
|
|
CN105287604B
(zh)
|
2010-11-08 |
2019-07-09 |
阿尔比里奥公司 |
含ibat抑制剂和胆汁酸结合剂的药物组合
|
|
CA2826649C
(en)
|
2011-02-25 |
2016-07-26 |
Merck Sharp & Dohme Corp. |
Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
|
|
EP2680874A2
(en)
|
2011-03-04 |
2014-01-08 |
Pfizer Inc |
Edn3-like peptides and uses thereof
|
|
UY34194A
(es)
|
2011-07-15 |
2013-02-28 |
Astrazeneca Ab |
?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
|
|
CN102304105B
(zh)
*
|
2011-07-15 |
2013-07-10 |
鲁南新时代生物技术有限公司 |
一种制备高纯度奥利司他的方法
|
|
CN103030613B
(zh)
*
|
2011-09-29 |
2014-11-12 |
北大方正集团有限公司 |
一种利普司他汀的提纯方法
|
|
JP2013249293A
(ja)
*
|
2012-06-04 |
2013-12-12 |
Kao Corp |
リパーゼ活性阻害剤、抗真菌剤、及びフケ抑制剤
|
|
BR112015002080A2
(pt)
|
2012-08-02 |
2017-07-04 |
Merck Sharp & Dohme |
composto, composição farmacêutica, uso de um composto, e, método de tratamento ou de prevenção de um transtorno, de uma condição ou de uma doença
|
|
WO2014060445A1
(en)
|
2012-10-19 |
2014-04-24 |
Akzo Nobel Chemicals International B.V. |
Method for preparing high purity orlistat
|
|
CN102936234B
(zh)
*
|
2012-11-15 |
2015-04-01 |
江苏阿尔法药业有限公司 |
一种制备脂肪酶抑制剂奥利司他的方法
|
|
CN102993134B
(zh)
*
|
2012-12-31 |
2015-08-05 |
鲁南新时代生物技术有限公司 |
一种利普司他汀的提纯方法
|
|
MX2015010935A
(es)
|
2013-02-22 |
2015-10-29 |
Merck Sharp & Dohme |
Compuestos biciclicos antidiabeticos.
|
|
EP2970119B1
(en)
|
2013-03-14 |
2021-11-03 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
JP2016514670A
(ja)
|
2013-03-15 |
2016-05-23 |
シナジー ファーマシューティカルズ インコーポレイテッド |
他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
|
|
US9708367B2
(en)
|
2013-03-15 |
2017-07-18 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase and their uses
|
|
CA2909442A1
(en)
|
2013-04-17 |
2014-10-23 |
Pfizer Inc. |
N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
|
|
SI3004138T1
(sl)
|
2013-06-05 |
2024-07-31 |
Bausch Health Ireland Limited |
Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
BR112017003745A2
(pt)
|
2014-08-29 |
2017-12-05 |
Tes Pharma S R L |
inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico
|
|
US10743813B2
(en)
|
2014-09-11 |
2020-08-18 |
Rattan Nath |
Diabetes control using postprandial feedback
|
|
WO2016055901A1
(en)
|
2014-10-08 |
2016-04-14 |
Pfizer Inc. |
Substituted amide compounds
|
|
US12427121B2
(en)
|
2016-05-05 |
2025-09-30 |
Aquestive Therapeutics, Inc. |
Enhanced delivery epinephrine compositions
|
|
US11273131B2
(en)
|
2016-05-05 |
2022-03-15 |
Aquestive Therapeutics, Inc. |
Pharmaceutical compositions with enhanced permeation
|
|
US12433850B2
(en)
|
2016-05-05 |
2025-10-07 |
Aquestive Therapeutics, Inc. |
Enhanced delivery epinephrine and prodrug compositions
|
|
KR20230137362A
(ko)
|
2016-05-05 |
2023-10-04 |
어퀘스티브 테라퓨틱스, 아이엔씨. |
강화된 전달 에프네프린 조성물
|
|
US20180134667A1
(en)
|
2016-10-14 |
2018-05-17 |
TES Pharma S.r.I. |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
|
|
US11072602B2
(en)
|
2016-12-06 |
2021-07-27 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
|
EP3558298A4
(en)
|
2016-12-20 |
2020-08-05 |
Merck Sharp & Dohme Corp. |
ANTIDIABETIC SPIROCHROMAN COMPOUNDS
|
|
SG11202104550WA
(en)
|
2018-11-20 |
2021-05-28 |
Tes Pharma S R L |
INHIBITORS OF a-AMINO-ß-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE
|
|
KR20210116548A
(ko)
|
2019-01-18 |
2021-09-27 |
아스트라제네카 아베 |
Pcsk9 억제제 및 이의 이용 방법
|
|
NL2022615B1
(en)
|
2019-02-21 |
2020-08-31 |
Patrick Alexander Unger |
Pharmaceutical composition comprising tetrahydrocannabivarin for the prevention and treatment of overweight
|
|
US20230338387A1
(en)
|
2020-02-05 |
2023-10-26 |
Nof Corporation |
Agent For Treating Or Preventing Pancreatic Fistula
|