BG60428B2 - Бензимидазоли,метод за получаването им и лекарствени средства, които ги съдържат - Google Patents

Бензимидазоли,метод за получаването им и лекарствени средства, които ги съдържат Download PDF

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Publication number
BG60428B2
BG60428B2 BG98420A BG9842094A BG60428B2 BG 60428 B2 BG60428 B2 BG 60428B2 BG 98420 A BG98420 A BG 98420A BG 9842094 A BG9842094 A BG 9842094A BG 60428 B2 BG60428 B2 BG 60428B2
Authority
BG
Bulgaria
Prior art keywords
group
methyl
carbon atoms
phenyl
hydrogen atom
Prior art date
Application number
BG98420A
Other languages
Bulgarian (bg)
English (en)
Inventor
Volkhard Austel
Joachim Heider
Wolfgang Eberlein
Willi Diederen
Walter Haarmann
Original Assignee
Dr. Karl Thomae Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782837161 external-priority patent/DE2837161A1/de
Priority claimed from DE19792922336 external-priority patent/DE2922336A1/de
Application filed by Dr. Karl Thomae Gmbh filed Critical Dr. Karl Thomae Gmbh
Publication of BG60428B2 publication Critical patent/BG60428B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG98420A 1978-08-25 1994-01-25 Бензимидазоли,метод за получаването им и лекарствени средства, които ги съдържат BG60428B2 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782837161 DE2837161A1 (de) 1978-08-25 1978-08-25 Neue benzimidazole und deren verwendung
DE19792922336 DE2922336A1 (de) 1979-06-01 1979-06-01 Neue in 5- oder 6-stellung durch einen pyridazinonring substituierte benzimidazole und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
BG60428B2 true BG60428B2 (bg) 1995-03-31

Family

ID=25775527

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98420A BG60428B2 (bg) 1978-08-25 1994-01-25 Бензимидазоли,метод за получаването им и лекарствени средства, които ги съдържат

Country Status (17)

Country Link
US (1) US4361563A (nl)
EP (1) EP0008391B1 (nl)
AU (1) AU528825B2 (nl)
BG (1) BG60428B2 (nl)
CA (1) CA1134362A (nl)
CS (1) CS410191A3 (nl)
DE (1) DE2962051D1 (nl)
DK (1) DK152496C (nl)
ES (2) ES8101067A1 (nl)
FI (1) FI66372C (nl)
GR (1) GR69998B (nl)
HK (1) HK50585A (nl)
IE (1) IE48814B1 (nl)
MX (1) MX9202731A (nl)
NL (1) NL980035I2 (nl)
PH (1) PH17515A (nl)
SG (1) SG285G (nl)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
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DE3129447A1 (de) * 1981-07-25 1983-02-10 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel"
US4699909A (en) * 1981-07-25 1987-10-13 Dr. Karl Thomae Gmbh Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones
US4353905A (en) * 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
EP0097353B1 (en) * 1982-06-21 1990-08-16 The Wellcome Foundation Limited Improved process for interferon production
US4734415A (en) * 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
US4717730A (en) * 1982-12-03 1988-01-05 Warner-Lambert Company 4,5-dihydro-6-(substituted)phenyl-5-methyl-3-(2H)-pyridazinones and pharmaceutical compositions containing the compounds as active components
US4521416A (en) * 1983-03-22 1985-06-04 Warner-Lambert Company 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones
GB8320005D0 (en) * 1983-07-25 1983-08-24 Fujisawa Pharmaceutical Co Benzothiazoline derivatives
US4591591A (en) * 1984-03-08 1986-05-27 Eli Lilly And Company Pyridazinone derivatives as inotropic agents
CA1248099A (en) * 1984-05-14 1989-01-03 David W. Robertson Indoline and 2-indolinone derivatives
US4647564A (en) * 1984-05-14 1987-03-03 Eli Lilly And Company Inotropic agents
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
US4617302A (en) * 1984-10-15 1986-10-14 Eli Lilly And Company Inotropic agents
DE3505609A1 (de) * 1985-02-19 1986-08-21 Merck Patent Gmbh, 6100 Darmstadt Benzimidazolyl-pyridazinone
DE3511110A1 (de) * 1985-03-27 1986-10-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4906630A (en) * 1985-11-22 1990-03-06 Rorer Pharmaceutical Corporation Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
US4725686A (en) * 1985-11-22 1988-02-16 William H. Rorer, Inc. Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
US4868300A (en) * 1985-11-22 1989-09-19 Rorer Pharmaceutical Corporation Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
US4785101A (en) * 1985-11-22 1988-11-15 Rorer Pharmaceutical Corporation Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their uses
DE3623944A1 (de) * 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4859672A (en) * 1986-10-29 1989-08-22 Rorer Pharmaceutical Corporation Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
DE3704879A1 (de) * 1987-02-17 1988-08-25 Merck Patent Gmbh Pyridazinonderivate
DE3734083A1 (de) * 1987-10-08 1989-04-20 Heumann Pharma Gmbh & Co Benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE68917485T2 (de) * 1988-01-23 1995-02-09 Kyowa Hakko Kogyo Kk Pyridazinon-Derivate und diese enthaltende pharmazeutische Zubereitungen.
DE3805635A1 (de) * 1988-02-24 1989-09-07 Thomae Gmbh Dr K Verwendung von benzimidazolen zur herstellung eines arzneimittels mit antiischaemischen wirkungen am herzen und dessen kombinationen mit ss-blockern oder bradycardica
DE3814057A1 (de) * 1988-04-26 1989-11-09 Heumann Pharma Gmbh & Co 6-oxo-pyridazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5338743A (en) * 1988-06-06 1994-08-16 Fujisawa Pharmaceutical Co., Ltd. New use of the adenosine antagonist
ES2080064T3 (es) * 1988-07-11 1996-02-01 Akzo Nobel Nv Derivados de piridazinona.
DE3830054A1 (de) * 1988-09-03 1990-03-15 Boehringer Mannheim Gmbh Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE3908531A1 (de) * 1989-03-16 1990-09-20 Thomae Gmbh Dr K Arzneimittel mit einer positiv inotropen wirkung, enthaltend eine synergistisch wirkende mischung, bestehend aus einem benzimidazol und einem ss-blocker, deren herstellung und deren verwendung
DE3934436A1 (de) * 1989-06-01 1991-04-18 Thomae Gmbh Dr K 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5364646A (en) * 1990-01-10 1994-11-15 Dr. Karl Thomae Gmbh Oral pharmaceutical forms of pimobendan
DE4001622A1 (de) * 1990-01-20 1991-07-25 Thomae Gmbh Dr K Orale arzneimittelformen von pimobendan
ATE211384T1 (de) * 1991-01-29 2002-01-15 Fujisawa Pharmaceutical Co Verwendung von adenosinantagonisten zur vorbeugung und behandlung von pankreatitis und ulcera
ES2205527T3 (es) * 1997-06-10 2004-05-01 Glaxo Group Limited Derivados de bencimidazol.
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
CA2347939C (en) 1998-10-23 2006-10-10 Akira Matsumori Composition for the treatment of rheumatism, hepatitis or pancreatitis
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
ES2298277T3 (es) * 2000-07-31 2008-05-16 Carl Ernest Alexander Composicion y dispositivo de higiene oral personal.
CA2451699A1 (en) * 2001-06-26 2003-01-09 Beth Israel Deaconess Medical Center Compositions and methods for inhibiting platelet activation and thrombosis
DE10203086A1 (de) * 2002-01-28 2003-07-31 Bayer Ag 5-Ring Heterozyklen
DE102004011512B4 (de) 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
JP4714921B2 (ja) * 2005-02-14 2011-07-06 トーアエイヨー株式会社 ピモベンダンの製造法及びその中間体
CA2618634A1 (en) * 2005-08-15 2007-02-22 Irm Llc Compounds and compositions as tpo mimetics
EP3210605A1 (en) 2005-11-14 2017-08-30 Boehringer Ingelheim Vetmedica GmbH Use of pde iii inhibitors for the treament of asymptomatic (occult) heart failure
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
FR2917975B1 (fr) 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
US8664252B2 (en) 2008-11-25 2014-03-04 Boehringer Ingelheim Vetmedica Gmbh Phosphodiesterase type III (PDE III) inhibitors or CA2+-sensitizing agents for the treatment of hypertrophic cardiomyopathy
NL1037569C2 (en) * 2009-12-18 2011-06-21 Eurovet Animal Health B V Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use.
RU2014109079A (ru) 2011-08-12 2015-09-20 Бёрингер Ингельхайм Ветмедика Гмбх Фармацевтическая композиция с маскированным вкусом
EP2825159B1 (en) 2012-03-15 2022-06-22 Boehringer Ingelheim Vetmedica GmbH Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
AU2014292086B2 (en) 2013-07-19 2019-08-08 Boehringer Ingelheim Vetmedica Gmbh Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
EP2925305B1 (en) 2013-12-04 2016-07-27 Boehringer Ingelheim Vetmedica GmbH Improved pharmaceutical compositions of pimobendan
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN106432095B (zh) * 2016-09-09 2019-04-16 东南大学 匹莫苯丹关键中间体6-(3,4-二氨基苯基)-5-甲基-4,5-二氢哒嗪-3(2h)-酮的制备
CN106518850B (zh) * 2016-11-15 2019-04-09 青岛农业大学 一种匹莫苯丹的化学合成方法
WO2022073954A1 (en) 2020-10-08 2022-04-14 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan in the anaesthesia of non-human mammals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2516040C2 (de) * 1974-06-10 1984-12-20 Dr. Karl Thomae Gmbh, 7950 Biberach Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2427943C2 (de) * 1974-06-10 1984-08-02 Dr. Karl Thomae Gmbh, 7950 Biberach Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
JPS5416485A (en) * 1977-07-08 1979-02-07 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivatives and their preparation

Also Published As

Publication number Publication date
NL980035I2 (nl) 1999-03-01
ES482789A0 (es) 1980-12-01
CS410191A3 (en) 1992-05-13
MX9202731A (es) 1992-06-30
SG285G (en) 1985-11-15
NL980035I1 (nl) 1999-02-01
ES8105001A1 (es) 1981-05-16
FI792628A (fi) 1980-02-26
ES8101067A1 (es) 1980-12-01
DK152496B (da) 1988-03-07
AU5027979A (en) 1980-02-28
EP0008391A1 (de) 1980-03-05
CA1134362A (en) 1982-10-26
US4361563A (en) 1982-11-30
IE48814B1 (en) 1985-05-29
EP0008391B1 (de) 1982-02-03
ES491970A0 (es) 1981-05-16
AU528825B2 (en) 1983-05-12
PH17515A (en) 1984-09-13
HK50585A (en) 1985-07-12
GR69998B (nl) 1982-07-23
IE791629L (en) 1980-02-25
FI66372B (fi) 1984-06-29
DE2962051D1 (en) 1982-03-11
DK354279A (da) 1980-02-26
DK152496C (da) 1988-07-25
FI66372C (fi) 1984-10-10

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