DK152496C - Analogifremgangsmaade til fremstilling af i 5- eller 6-stilling med en pyridazinonring substituerede benzimidazoler eller deres fysiologisk acceptable syreadditionssalte - Google Patents

Analogifremgangsmaade til fremstilling af i 5- eller 6-stilling med en pyridazinonring substituerede benzimidazoler eller deres fysiologisk acceptable syreadditionssalte

Info

Publication number
DK152496C
DK152496C DK354279A DK354279A DK152496C DK 152496 C DK152496 C DK 152496C DK 354279 A DK354279 A DK 354279A DK 354279 A DK354279 A DK 354279A DK 152496 C DK152496 C DK 152496C
Authority
DK
Denmark
Prior art keywords
physially
pyridazinon
preparing
acid addition
addition salts
Prior art date
Application number
DK354279A
Other languages
Danish (da)
English (en)
Other versions
DK354279A (da
DK152496B (da
Inventor
Volkhard Austel
Joachim Heider
Wolfgang Eberlein
Willi Diederen
Walter Haarmann
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782837161 external-priority patent/DE2837161A1/de
Priority claimed from DE19792922336 external-priority patent/DE2922336A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of DK354279A publication Critical patent/DK354279A/da
Publication of DK152496B publication Critical patent/DK152496B/da
Application granted granted Critical
Publication of DK152496C publication Critical patent/DK152496C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK354279A 1978-08-25 1979-08-24 Analogifremgangsmaade til fremstilling af i 5- eller 6-stilling med en pyridazinonring substituerede benzimidazoler eller deres fysiologisk acceptable syreadditionssalte DK152496C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19782837161 DE2837161A1 (de) 1978-08-25 1978-08-25 Neue benzimidazole und deren verwendung
DE2837161 1978-08-25
DE19792922336 DE2922336A1 (de) 1979-06-01 1979-06-01 Neue in 5- oder 6-stellung durch einen pyridazinonring substituierte benzimidazole und deren verwendung als arzneimittel
DE2922336 1979-06-01

Publications (3)

Publication Number Publication Date
DK354279A DK354279A (da) 1980-02-26
DK152496B DK152496B (da) 1988-03-07
DK152496C true DK152496C (da) 1988-07-25

Family

ID=25775527

Family Applications (1)

Application Number Title Priority Date Filing Date
DK354279A DK152496C (da) 1978-08-25 1979-08-24 Analogifremgangsmaade til fremstilling af i 5- eller 6-stilling med en pyridazinonring substituerede benzimidazoler eller deres fysiologisk acceptable syreadditionssalte

Country Status (17)

Country Link
US (1) US4361563A (nl)
EP (1) EP0008391B1 (nl)
AU (1) AU528825B2 (nl)
BG (1) BG60428B2 (nl)
CA (1) CA1134362A (nl)
CS (1) CS410191A3 (nl)
DE (1) DE2962051D1 (nl)
DK (1) DK152496C (nl)
ES (2) ES8101067A1 (nl)
FI (1) FI66372C (nl)
GR (1) GR69998B (nl)
HK (1) HK50585A (nl)
IE (1) IE48814B1 (nl)
MX (1) MX9202731A (nl)
NL (1) NL980035I2 (nl)
PH (1) PH17515A (nl)
SG (1) SG285G (nl)

Families Citing this family (61)

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US4521416A (en) * 1983-03-22 1985-06-04 Warner-Lambert Company 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones
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US4617302A (en) * 1984-10-15 1986-10-14 Eli Lilly And Company Inotropic agents
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US4785101A (en) * 1985-11-22 1988-11-15 Rorer Pharmaceutical Corporation Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their uses
US4868300A (en) * 1985-11-22 1989-09-19 Rorer Pharmaceutical Corporation Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
DE3623944A1 (de) * 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4859672A (en) * 1986-10-29 1989-08-22 Rorer Pharmaceutical Corporation Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
DE3704879A1 (de) * 1987-02-17 1988-08-25 Merck Patent Gmbh Pyridazinonderivate
DE3734083A1 (de) * 1987-10-08 1989-04-20 Heumann Pharma Gmbh & Co Benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0326307B1 (en) * 1988-01-23 1994-08-17 Kyowa Hakko Kogyo Co., Ltd. Novel pyridazinone derivatives and pharmaceutical preparations containing them
DE3805635A1 (de) * 1988-02-24 1989-09-07 Thomae Gmbh Dr K Verwendung von benzimidazolen zur herstellung eines arzneimittels mit antiischaemischen wirkungen am herzen und dessen kombinationen mit ss-blockern oder bradycardica
DE3814057A1 (de) * 1988-04-26 1989-11-09 Heumann Pharma Gmbh & Co 6-oxo-pyridazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5338743A (en) * 1988-06-06 1994-08-16 Fujisawa Pharmaceutical Co., Ltd. New use of the adenosine antagonist
DE68924308T2 (de) * 1988-07-11 1996-04-04 Akzo Nobel Nv Pyridazinon-Derivate.
DE3830054A1 (de) * 1988-09-03 1990-03-15 Boehringer Mannheim Gmbh Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE3908531A1 (de) * 1989-03-16 1990-09-20 Thomae Gmbh Dr K Arzneimittel mit einer positiv inotropen wirkung, enthaltend eine synergistisch wirkende mischung, bestehend aus einem benzimidazol und einem ss-blocker, deren herstellung und deren verwendung
DE3934436A1 (de) * 1989-06-01 1991-04-18 Thomae Gmbh Dr K 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5364646A (en) * 1990-01-10 1994-11-15 Dr. Karl Thomae Gmbh Oral pharmaceutical forms of pimobendan
DE4001622A1 (de) * 1990-01-20 1991-07-25 Thomae Gmbh Dr K Orale arzneimittelformen von pimobendan
CA2060138A1 (en) * 1991-01-29 1992-07-30 Youichi Shiokawa New use of the adenosine antagonist
JP4548866B2 (ja) * 1997-06-10 2010-09-22 グラクソ グループ リミテッド ベンゾイミダゾール誘導体
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DE10203086A1 (de) * 2002-01-28 2003-07-31 Bayer Ag 5-Ring Heterozyklen
DE102004011512B4 (de) 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
US8980894B2 (en) * 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
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RU2385865C2 (ru) * 2005-08-15 2010-04-10 Айрм Ллк Соединения и композиции в качестве миметиков тро
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MX2011005444A (es) 2008-11-25 2011-06-09 Boehringer Ingelheim Vetmed Inhibidores de la fosfodiesterasa tipo iii (pde iii) o agentes sensibilizantes a iones de ca(2+) para el tratamiento de la cardiomiopatia hipertrofica.
NL1037569C2 (en) * 2009-12-18 2011-06-21 Eurovet Animal Health B V Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use.
WO2013024036A1 (en) 2011-08-12 2013-02-21 Boehringer Ingelheim Vetmedica Gmbh Funny current (if) inhibitors for use in a method of treating and preventing heart failure in feline
EP2825159B1 (en) 2012-03-15 2022-06-22 Boehringer Ingelheim Vetmedica GmbH Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
WO2015007760A1 (en) 2013-07-19 2015-01-22 Boehringer Ingelheim Vetmedica Gmbh Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
EP3106150B1 (en) 2013-12-04 2021-07-28 Boehringer Ingelheim Vetmedica GmbH Improved pharmaceutical compositions of pimobendan
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN106432095B (zh) * 2016-09-09 2019-04-16 东南大学 匹莫苯丹关键中间体6-(3,4-二氨基苯基)-5-甲基-4,5-二氢哒嗪-3(2h)-酮的制备
CN106518850B (zh) * 2016-11-15 2019-04-09 青岛农业大学 一种匹莫苯丹的化学合成方法
WO2022073954A1 (en) 2020-10-08 2022-04-14 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan in the anaesthesia of non-human mammals
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DE2516040C2 (de) * 1974-06-10 1984-12-20 Dr. Karl Thomae Gmbh, 7950 Biberach Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2427943C2 (de) * 1974-06-10 1984-08-02 Dr. Karl Thomae Gmbh, 7950 Biberach Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
JPS5416485A (en) * 1977-07-08 1979-02-07 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivatives and their preparation

Also Published As

Publication number Publication date
AU5027979A (en) 1980-02-28
AU528825B2 (en) 1983-05-12
IE48814B1 (en) 1985-05-29
FI66372B (fi) 1984-06-29
CA1134362A (en) 1982-10-26
PH17515A (en) 1984-09-13
ES482789A0 (es) 1980-12-01
DK354279A (da) 1980-02-26
BG60428B2 (bg) 1995-03-31
HK50585A (en) 1985-07-12
EP0008391A1 (de) 1980-03-05
FI792628A (fi) 1980-02-26
DK152496B (da) 1988-03-07
GR69998B (nl) 1982-07-23
ES491970A0 (es) 1981-05-16
ES8105001A1 (es) 1981-05-16
SG285G (en) 1985-11-15
US4361563A (en) 1982-11-30
ES8101067A1 (es) 1980-12-01
MX9202731A (es) 1992-06-30
NL980035I2 (nl) 1999-03-01
IE791629L (en) 1980-02-25
NL980035I1 (nl) 1999-02-01
EP0008391B1 (de) 1982-02-03
FI66372C (fi) 1984-10-10
DE2962051D1 (en) 1982-03-11
CS410191A3 (en) 1992-05-13

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