BG25088A3 - Метод за получаване на 5,9-бета заместени 2-тетрахидро-фурфурил-6,7- бензоморфани и техните соли - Google Patents

Метод за получаване на 5,9-бета заместени 2-тетрахидро-фурфурил-6,7- бензоморфани и техните соли

Info

Publication number
BG25088A3
BG25088A3 BG030726A BG3072675A BG25088A3 BG 25088 A3 BG25088 A3 BG 25088A3 BG 030726 A BG030726 A BG 030726A BG 3072675 A BG3072675 A BG 3072675A BG 25088 A3 BG25088 A3 BG 25088A3
Authority
BG
Bulgaria
Prior art keywords
benzomorphanes
furfuryl
tetrahydro
salts
preparation
Prior art date
Application number
BG030726A
Other languages
Bulgarian (bg)
English (en)
Inventor
Herbert Merz
Adolf Langbein
Gerhard Walther
Klaus Stockhaus
Original Assignee
C.H.Boehringer Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H.Boehringer Sohn filed Critical C.H.Boehringer Sohn
Publication of BG25088A3 publication Critical patent/BG25088A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG030726A 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета заместени 2-тетрахидро-фурфурил-6,7- бензоморфани и техните соли BG25088A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2437610A DE2437610A1 (de) 1974-08-05 1974-08-05 Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
BG25088A3 true BG25088A3 (bg) 1978-07-12

Family

ID=5922448

Family Applications (3)

Application Number Title Priority Date Filing Date
BG031843A BG25090A3 (bg) 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета-заместени -2-тетрахидрофурфурил- 6,7-бензоморфани и техните соли
BG030726A BG25088A3 (bg) 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета заместени 2-тетрахидро-фурфурил-6,7- бензоморфани и техните соли
BG031842A BG25089A3 (bg) 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета-заместени 2-тетра-хидрофурфурил-6,7- бензоморфани и техните соли

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BG031843A BG25090A3 (bg) 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета-заместени -2-тетрахидрофурфурил- 6,7-бензоморфани и техните соли

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG031842A BG25089A3 (bg) 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета-заместени 2-тетра-хидрофурфурил-6,7- бензоморфани и техните соли

Country Status (27)

Country Link
US (1) US3982005A (OSRAM)
JP (1) JPS60358B2 (OSRAM)
AT (1) AT348140B (OSRAM)
BE (1) BE832099R (OSRAM)
BG (3) BG25090A3 (OSRAM)
CA (1) CA1049008A (OSRAM)
CH (7) CH613963A5 (OSRAM)
CS (1) CS189717B2 (OSRAM)
DD (1) DD122685A5 (OSRAM)
DE (1) DE2437610A1 (OSRAM)
DK (1) DK138992C (OSRAM)
ES (6) ES452764A1 (OSRAM)
FI (1) FI63229C (OSRAM)
FR (1) FR2320096A2 (OSRAM)
GB (1) GB1513950A (OSRAM)
HU (1) HU177952B (OSRAM)
IE (1) IE42216B1 (OSRAM)
IL (1) IL47860A (OSRAM)
LU (1) LU73138A1 (OSRAM)
NL (1) NL7509249A (OSRAM)
NO (1) NO143460C (OSRAM)
PH (1) PH13687A (OSRAM)
PL (3) PL99819B1 (OSRAM)
RO (3) RO67390A (OSRAM)
SE (1) SE425392B (OSRAM)
SU (3) SU591147A3 (OSRAM)
ZA (1) ZA754997B (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) * 1979-08-31 1981-04-09 Shin Etsu Chem Co Ltd Production of alkenyloxy group-containing organopolysiloxane
US8329897B2 (en) 2007-07-26 2012-12-11 Vitae Pharmaceuticals, Inc. Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
CA2704628C (en) 2007-11-16 2016-11-29 Boehringer Ingelheim International Gmbh Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
US8569292B2 (en) 2008-05-01 2013-10-29 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
PL2300461T3 (pl) 2008-05-01 2013-09-30 Vitae Pharmaceuticals Inc Cykliczne inhibitory dehydrogenazy 11beta-hydroksysteroidów 1
CA2723034A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001151A1 (es) 2008-05-13 2010-08-13 Boehringer Ingelheim Int Compuestos derivados de acidos carbociclicos aliciclicos de benzomorfanos, procedimiento de preparacion, composicion farmaceutica, utiles para tratar enfermedades influenciadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa, como trastornos metabolicos.
JP5379160B2 (ja) 2008-07-25 2013-12-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
JP5656986B2 (ja) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TWI531571B (zh) * 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives
CN116507689A (zh) 2020-11-26 2023-07-28 信越化学工业株式会社 室温固化性有机聚硅氧烷组合物及物品以及水解性有机硅烷化合物及其制造方法
EP4397695A4 (en) 2021-09-03 2025-09-10 Shinetsu Chemical Co ORGANOPOLYSILOXANE COMPOUND, ROOM TEMPERATURE CURABLE ORGANOPOLYSILOXANE COMPOSITION AND ARTICLE

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (OSRAM) * 1958-09-22
US3700734A (en) * 1969-01-23 1972-10-24 Merck & Co Inc 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) * 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166803B2 (OSRAM) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2200596A1 (de) * 1972-01-07 1973-07-12 Boehringer Sohn Ingelheim N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
IE42216L (en) 1976-02-05
CH615678A5 (OSRAM) 1980-02-15
ZA754997B (en) 1977-04-27
CA1049008A (en) 1979-02-20
AU8364675A (en) 1977-02-10
PL99819B1 (pl) 1978-08-31
LU73138A1 (OSRAM) 1977-04-13
FR2320096B2 (OSRAM) 1978-09-01
CH615679A5 (OSRAM) 1980-02-15
DK138992B (da) 1978-11-27
PL99816B1 (pl) 1978-08-31
CH613963A5 (OSRAM) 1979-10-31
BG25090A3 (bg) 1978-07-12
DK138992C (da) 1979-04-30
DK352875A (da) 1976-02-06
IL47860A0 (en) 1975-11-25
ES452766A1 (es) 1977-10-01
ES452767A1 (es) 1977-10-01
SU587859A3 (ru) 1978-01-05
US3982005A (en) 1976-09-21
CH615677A5 (OSRAM) 1980-02-15
SE425392B (sv) 1982-09-27
JPS60358B2 (ja) 1985-01-07
SE7508789L (sv) 1976-02-10
CH615680A5 (OSRAM) 1980-02-15
ATA523775A (de) 1978-06-15
AT348140B (de) 1979-01-25
PH13687A (en) 1980-09-01
RO67390A (ro) 1981-06-30
NL7509249A (nl) 1976-02-09
ES452764A1 (es) 1977-10-16
IE42216B1 (en) 1980-07-02
IL47860A (en) 1979-01-31
ES452763A1 (es) 1977-10-01
BE832099R (fr) 1976-02-04
FI63229B (fi) 1983-01-31
CH616421A5 (OSRAM) 1980-03-31
NO143460C (no) 1981-02-18
FR2320096A2 (fr) 1977-03-04
JPS5139673A (en) 1976-04-02
DE2437610A1 (de) 1976-02-26
CH616420A5 (OSRAM) 1980-03-31
ES452768A1 (es) 1977-10-01
PL99838B1 (pl) 1978-08-31
SU591147A3 (ru) 1978-01-30
RO72736A (ro) 1982-09-09
CS189717B2 (en) 1979-04-30
BG25089A3 (bg) 1978-07-12
SU587858A3 (ru) 1978-01-05
RO72735A (ro) 1982-09-09
FI752211A7 (OSRAM) 1976-02-06
DD122685A5 (OSRAM) 1976-10-20
HU177952B (en) 1982-02-28
GB1513950A (en) 1978-06-14
FI63229C (fi) 1983-05-10
ES452765A1 (es) 1977-10-16
NO143460B (no) 1980-11-10
NO752731L (OSRAM) 1976-02-06

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