BG106639A - Производни на индолил-3-глиоксилова киселина с терапевтично значими свойства - Google Patents

Производни на индолил-3-глиоксилова киселина с терапевтично значими свойства Download PDF

Info

Publication number
BG106639A
BG106639A BG106639A BG10663902A BG106639A BG 106639 A BG106639 A BG 106639A BG 106639 A BG106639 A BG 106639A BG 10663902 A BG10663902 A BG 10663902A BG 106639 A BG106639 A BG 106639A
Authority
BG
Bulgaria
Prior art keywords
group
glyoxylamide
alkyl
groups
acid
Prior art date
Application number
BG106639A
Other languages
Bulgarian (bg)
English (en)
Inventor
Bernd Nickel
Thomas Klenner
Gerald Bacher
Thomas Beckers
Peter Emig
Juergen Engel
Erik Bruyneel
Guenter Kamp
Kirsten Peters
Original Assignee
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19946301A external-priority patent/DE19946301A1/de
Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa
Publication of BG106639A publication Critical patent/BG106639A/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG106639A 1999-09-28 2002-04-23 Производни на индолил-3-глиоксилова киселина с терапевтично значими свойства BG106639A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19946301A DE19946301A1 (de) 1998-04-02 1999-09-28 Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
PCT/EP2000/009390 WO2001022954A2 (de) 1999-09-28 2000-09-26 Indolyl-3-glyoxylsäurederivate als antitumormittel

Publications (1)

Publication Number Publication Date
BG106639A true BG106639A (bg) 2002-12-29

Family

ID=7923485

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106639A BG106639A (bg) 1999-09-28 2002-04-23 Производни на индолил-3-глиоксилова киселина с терапевтично значими свойства

Country Status (32)

Country Link
EP (1) EP1218006B1 (cs)
JP (1) JP2003510274A (cs)
KR (1) KR100759242B1 (cs)
CN (1) CN1301712C (cs)
AR (1) AR025885A1 (cs)
AT (1) ATE459356T1 (cs)
AU (1) AU783436B2 (cs)
BG (1) BG106639A (cs)
BR (1) BR0014378A (cs)
CA (1) CA2386069C (cs)
CZ (1) CZ303246B6 (cs)
DE (1) DE50015879D1 (cs)
DZ (1) DZ3196A1 (cs)
EE (1) EE200200169A (cs)
ES (1) ES2342042T3 (cs)
GE (1) GEP20043250B (cs)
HK (1) HK1048941B (cs)
HR (1) HRP20020369A2 (cs)
HU (1) HUP0202788A3 (cs)
IL (2) IL148670A0 (cs)
IS (1) IS6319A (cs)
MX (1) MXPA02002824A (cs)
NO (1) NO322614B1 (cs)
NZ (1) NZ517988A (cs)
PL (1) PL199576B1 (cs)
RS (1) RS51302B (cs)
RU (1) RU2282444C2 (cs)
SK (1) SK287533B6 (cs)
TW (1) TWI269654B (cs)
UA (1) UA75872C2 (cs)
WO (1) WO2001022954A2 (cs)
ZA (1) ZA200202556B (cs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
IL152682A0 (en) 2000-05-31 2003-06-24 Astrazeneca Ab Indole derivatives with vascular damaging activity
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
EP1595878A1 (de) * 2004-05-15 2005-11-16 Zentaris GmbH Indolderivate mit Apoptose induzierender Wirkung
KR101132599B1 (ko) * 2003-06-05 2012-06-21 아에테르나 젠타리스 게엠베하 아폽토시스 유도 효과를 갖는 인돌 유도체
EP1484329A1 (de) * 2003-06-06 2004-12-08 Zentaris GmbH Indolderivate mit Apoptose induzierender Wirkung
US20050124623A1 (en) 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
AU2005247943A1 (en) * 2004-05-23 2005-12-08 Gerard M. Housey Theramutein modulators
JP2008519036A (ja) * 2004-11-08 2008-06-05 バクスター・インターナショナル・インコーポレイテッド チューブリン阻害化合物のナノ粒子組成物
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
ES2644450T3 (es) 2004-12-31 2017-11-29 Dr. Reddy's Laboratories Ltd. Nuevos derivados de bencilamina como inhibidores de CETP
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
US20080241274A1 (en) * 2006-11-28 2008-10-02 Ziopharm Oncology, Inc. Indibulin therapy
US9199967B2 (en) 2011-08-18 2015-12-01 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (CETP) inhibitors
CA2850022C (en) 2011-09-27 2018-05-01 Dr. Reddy's Laboratories, Ltd. 5 - benzylaminomethyl - 6 - aminopyrazolo [3,4-b] pyridine derivatives as cholesteryl ester-transfer protein (cetp) inhibitors useful for the treatment of atherosclerosis
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
AU2014228822A1 (en) 2013-03-15 2015-10-01 Memorial Sloan-Kettering Cancer Center HSP90-targeted cardiac imaging and therapy
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
CN109111501B (zh) * 2017-06-23 2022-04-22 首都医科大学 脂肪氨基酸修饰的吲哚乙醇衍生物, 其合成，活性和应用
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2020247054A1 (en) 2019-06-05 2020-12-10 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
WO2022182415A1 (en) 2021-02-24 2022-09-01 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
RU2047603C1 (ru) * 1991-12-09 1995-11-10 Матвей Абрамович Рехтер 1-алкил-2-ацилиндолы и способы их получения
NZ314207A (en) * 1992-09-28 2000-12-22 Vertex Pharma 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers
KR100293684B1 (ko) * 1992-10-20 2001-09-17 히라이 가쯔히꼬 호산구침윤억제제
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
WO1998045431A1 (fr) 1997-04-08 1998-10-15 Banyu Pharmaceutical Co., Ltd. Gene associe a la metastase cancereuse
TR200002447T2 (tr) * 1998-02-25 2000-11-21 Genetics Institute, Inc. Fosfolinaz enzimlerinin inhibitörleri
HUP0102612A2 (hu) * 1998-03-12 2001-11-28 Novo Nordisk A/S Fehérje-tirozinfoszfatázokat moduláló vegyületek és ezeket tartalmazó gyógyászati készítmények
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
HUP0101625A3 (en) * 1998-04-28 2002-12-28 Elbion Ag New hydroxyindoles, their use as phosphodiesterase 4 inhibitors and method for producing same
JP2000239252A (ja) * 1999-02-16 2000-09-05 Mitsubishi Chemicals Corp インドール誘導体
AU4834200A (en) * 1999-05-10 2000-11-21 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof

Also Published As

Publication number Publication date
NO322614B1 (no) 2006-11-06
ATE459356T1 (de) 2010-03-15
GEP20043250B (en) 2004-06-25
KR20030019295A (ko) 2003-03-06
AR025885A1 (es) 2002-12-18
CN1376064A (zh) 2002-10-23
AU783436B2 (en) 2005-10-27
WO2001022954A3 (de) 2002-03-28
SK287533B6 (sk) 2011-01-04
CA2386069A1 (en) 2001-04-05
CN1301712C (zh) 2007-02-28
NO20021367L (no) 2002-05-22
EP1218006A2 (de) 2002-07-03
DZ3196A1 (fr) 2001-04-05
TWI269654B (en) 2007-01-01
DE50015879D1 (de) 2010-04-15
CZ20021005A3 (cs) 2004-01-14
HUP0202788A3 (en) 2003-02-28
PL364811A1 (en) 2004-12-13
KR100759242B1 (ko) 2007-09-18
NZ517988A (en) 2004-10-29
CA2386069C (en) 2012-08-14
RU2282444C2 (ru) 2006-08-27
UA75872C2 (en) 2006-06-15
PL199576B1 (pl) 2008-10-31
IL148670A (en) 2009-09-01
EP1218006B1 (de) 2010-03-03
HRP20020369A2 (en) 2004-12-31
JP2003510274A (ja) 2003-03-18
SK4072002A3 (en) 2003-11-04
NO20021367D0 (no) 2002-03-19
HUP0202788A2 (hu) 2003-01-28
EE200200169A (et) 2003-04-15
IL148670A0 (en) 2002-09-12
RS51302B (sr) 2010-12-31
HK1048941B (zh) 2007-09-21
MXPA02002824A (es) 2003-07-21
CZ303246B6 (cs) 2012-06-20
IS6319A (is) 2002-03-21
AU7782900A (en) 2001-04-30
ES2342042T3 (es) 2010-07-01
HK1048941A1 (en) 2003-04-25
ZA200202556B (en) 2003-08-27
WO2001022954A2 (de) 2001-04-05
YU22702A (sh) 2004-12-31
BR0014378A (pt) 2003-07-29

Similar Documents

Publication Publication Date Title
BG106639A (bg) Производни на индолил-3-глиоксилова киселина с терапевтично значими свойства
US20080057124A1 (en) Indolyl-3-glyoxylic acid derivatives having therapeutically valuable properties
WO2003074045A1 (en) Antitumor agent comprising combination of sulfonamide-containing heterocyclic compound with angiogenesis inhibitor
RU2002111866A (ru) Производные N-замещенного индол-3-глиоксиламида - противоопухолевое лекарственное средство и средство, подавляющее ангиогенез (варианты), фармацевтическая композиция и противоопухолевое лекарственное средство (варианты)
JP2001517250A (ja) ナフタレンスルホン酸誘導体を含有する相乗作用抗腫瘍組成物
KR102382771B1 (ko) 증식성 질환을 위한 조합 치료
JP2024531492A (ja) Ｐａｒｐ阻害剤に耐性のある患者のｔｈ－３０２による治療
US20050288298A1 (en) Methods for the treatment of synucleinopathies
CN103619331A (zh) 抗癌治疗剂
ES3015427T3 (en) Use of non-peptide nk1 antagonists in a predetermined dose for the treatment of cancer
US20060009475A1 (en) Quinazolinone compounds in combined modalities for improved cancer treatment
US20220016082A1 (en) Combination therapies for high and very high risk mds
HK1222808A1 (zh) 急性骨髓性白血病(aml)的新型组合治疗
KR20100131457A (ko) 시티딘 유도체 및 카르보플라틴을 함유하는 항종양제