IL148670A - Indolyl-3-glyoxylic acid derivatives comprising therapeutically valuable properties - Google Patents
Indolyl-3-glyoxylic acid derivatives comprising therapeutically valuable propertiesInfo
- Publication number
- IL148670A IL148670A IL148670A IL14867002A IL148670A IL 148670 A IL148670 A IL 148670A IL 148670 A IL148670 A IL 148670A IL 14867002 A IL14867002 A IL 14867002A IL 148670 A IL148670 A IL 148670A
- Authority
- IL
- Israel
- Prior art keywords
- indolyl
- acid derivatives
- glyoxylic acid
- therapeutically valuable
- valuable properties
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention relates to the use of N-substituted indol-3- glyoxylamides of general formula 1 for treating tumors, in particular, in cases of drug resistance and metastatic carcinoma, and as angiogenesis inhibitors having distinctly fewer side effects, in particular, distinctly lower neurotoxicity. The invention also relates to medicaments containing the inventive compounds.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19946301A DE19946301A1 (en) | 1998-04-02 | 1999-09-28 | Antitumor agents and angiogenesis inhibitors having low neurotoxicity, comprise indole-3-glyoxylamide derivatives, are effective against resistant and metastasis-forming carcinomas |
| PCT/EP2000/009390 WO2001022954A2 (en) | 1999-09-28 | 2000-09-26 | Indolyl-3-glyoxylic acid derivatives serving as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL148670A true IL148670A (en) | 2009-09-01 |
Family
ID=7923485
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14867000A IL148670A0 (en) | 1999-09-28 | 2000-09-26 | Indolyl-3-glyoxylic acid derivatives comprising therapeutically valuable properties |
| IL148670A IL148670A (en) | 1999-09-28 | 2002-03-13 | Indolyl-3-glyoxylic acid derivatives comprising therapeutically valuable properties |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14867000A IL148670A0 (en) | 1999-09-28 | 2000-09-26 | Indolyl-3-glyoxylic acid derivatives comprising therapeutically valuable properties |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP1218006B1 (en) |
| JP (1) | JP2003510274A (en) |
| KR (1) | KR100759242B1 (en) |
| CN (1) | CN1301712C (en) |
| AR (1) | AR025885A1 (en) |
| AT (1) | ATE459356T1 (en) |
| AU (1) | AU783436B2 (en) |
| BG (1) | BG106639A (en) |
| BR (1) | BR0014378A (en) |
| CA (1) | CA2386069C (en) |
| CZ (1) | CZ303246B6 (en) |
| DE (1) | DE50015879D1 (en) |
| DZ (1) | DZ3196A1 (en) |
| EE (1) | EE200200169A (en) |
| ES (1) | ES2342042T3 (en) |
| GE (1) | GEP20043250B (en) |
| HK (1) | HK1048941B (en) |
| HR (1) | HRP20020369A2 (en) |
| HU (1) | HUP0202788A3 (en) |
| IL (2) | IL148670A0 (en) |
| IS (1) | IS6319A (en) |
| MX (1) | MXPA02002824A (en) |
| NO (1) | NO322614B1 (en) |
| NZ (1) | NZ517988A (en) |
| PL (1) | PL199576B1 (en) |
| RS (1) | RS51302B (en) |
| RU (1) | RU2282444C2 (en) |
| SK (1) | SK287533B6 (en) |
| TW (1) | TWI269654B (en) |
| UA (1) | UA75872C2 (en) |
| WO (1) | WO2001022954A2 (en) |
| ZA (1) | ZA200202556B (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19962300A1 (en) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | New N-benzylindolyl glyoxylic acid derivatives are useful as antitumor agents |
| US7030123B2 (en) | 2000-05-31 | 2006-04-18 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| DE10037310A1 (en) | 2000-07-28 | 2002-02-07 | Asta Medica Ag | New indole derivatives and their use as medicines |
| EP1484329A1 (en) * | 2003-06-06 | 2004-12-08 | Zentaris GmbH | Indole derivatives with apoptosis inducing activity |
| EP1595878A1 (en) * | 2004-05-15 | 2005-11-16 | Zentaris GmbH | Indole derivatives with apoptosis inducing activity |
| NZ543853A (en) * | 2003-06-05 | 2009-09-25 | Zentaris Gmbh | Indole derivatives with apoptosis-inducing effect |
| US20050124623A1 (en) | 2003-11-26 | 2005-06-09 | Bender John A. | Diazaindole-dicarbonyl-piperazinyl antiviral agents |
| CN103356636A (en) * | 2004-05-23 | 2013-10-23 | 杰勒德·M·豪斯 | Theramutein modulators |
| BRPI0517652A (en) * | 2004-11-08 | 2008-10-14 | Baxter Healthcare Sa | nanoparticulate pharmaceutical compositions of tubulin inhibitors, methods for their preparation and their uses |
| US20060100432A1 (en) | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| KR101238525B1 (en) | 2004-12-31 | 2013-02-28 | 레디 유에스 테라퓨틱스 인코포레이티드 | Novel benzylamine derivatives as cetp inhibitors |
| US7851476B2 (en) | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
| US7807671B2 (en) | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
| JP2010511041A (en) * | 2006-11-28 | 2010-04-08 | ジオファーム オンコロジー， インコーポレイテッド | Use of indolyl-3-glyoxylic acid derivatives containing indibulin alone or in combination with additional agents for treating cancer |
| CN103827105B (en) | 2011-08-18 | 2016-08-17 | 雷迪博士实验室有限公司 | Substituted heterocyclic amine compound as cholesterol ester transfer protein (CETP) inhibitor |
| JP6140168B2 (en) | 2011-09-27 | 2017-05-31 | ドクター レディズ ラボラトリーズ リミテッド | 5-Benzylaminomethyl-6-aminopyrazolo [3,4-B] pyridine derivatives as cholesteryl ester transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| AU2014228822A1 (en) | 2013-03-15 | 2015-10-01 | Memorial Sloan-Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| CN109111501B (en) * | 2017-06-23 | 2022-04-22 | 首都医科大学 | Fatty amino acid modified indole ethanol derivative, and synthesis, activity and application thereof |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
| JP3163631B2 (en) * | 1992-10-20 | 2001-05-08 | 東レ株式会社 | Eosinophil infiltration inhibitor |
| DE19636150A1 (en) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituted indole-3-glyoxylamides with antiasthmatic, antiallergic and immunosuppressive / immunomodulating effects |
| CA2286038A1 (en) | 1997-04-08 | 1998-10-15 | Banyu Pharmaceutical Co., Ltd. | Cancerous metastasis-associated gene |
| GEP20032920B (en) * | 1998-02-25 | 2003-03-25 | Genetics Inst | Inhibitors of Phospholipase Enzymes |
| WO1999046237A1 (en) * | 1998-03-12 | 1999-09-16 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases |
| DE19814838C2 (en) * | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylic acid derivatives with anti-tumor effects |
| ES2222706T3 (en) * | 1998-04-28 | 2005-02-01 | Elbion Ag | NEW HYDROXYINDOLS, THEIR USE AS INHIBITORS OF PHOSPHODESTERASE 4, AND PROCEDURE FOR THEIR PREPARATION. |
| JP2000239252A (en) * | 1999-02-16 | 2000-09-05 | Mitsubishi Chemicals Corp | Indole derivative |
| AU4834200A (en) * | 1999-05-10 | 2000-11-21 | Protarga, Inc. | Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof |
-
2000
- 2000-09-22 TW TW089119680A patent/TWI269654B/en not_active IP Right Cessation
- 2000-09-26 CA CA2386069A patent/CA2386069C/en not_active Expired - Fee Related
- 2000-09-26 BR BR0014378-2A patent/BR0014378A/en not_active Application Discontinuation
- 2000-09-26 ES ES00967789T patent/ES2342042T3/en not_active Expired - Lifetime
- 2000-09-26 SK SK407-2002A patent/SK287533B6/en not_active IP Right Cessation
- 2000-09-26 UA UA2002043433A patent/UA75872C2/en unknown
- 2000-09-26 RS YUP-227/02A patent/RS51302B/en unknown
- 2000-09-26 DZ DZ003196A patent/DZ3196A1/en active
- 2000-09-26 RU RU2002111866/15A patent/RU2282444C2/en not_active IP Right Cessation
- 2000-09-26 CN CNB008134499A patent/CN1301712C/en not_active Expired - Fee Related
- 2000-09-26 EP EP00967789A patent/EP1218006B1/en not_active Expired - Lifetime
- 2000-09-26 GE GEAP20006425A patent/GEP20043250B/en unknown
- 2000-09-26 HU HU0202788A patent/HUP0202788A3/en unknown
- 2000-09-26 AU AU77829/00A patent/AU783436B2/en not_active Ceased
- 2000-09-26 NZ NZ517988A patent/NZ517988A/en not_active IP Right Cessation
- 2000-09-26 PL PL364811A patent/PL199576B1/en not_active IP Right Cessation
- 2000-09-26 KR KR1020027003937A patent/KR100759242B1/en not_active IP Right Cessation
- 2000-09-26 AT AT00967789T patent/ATE459356T1/en not_active IP Right Cessation
- 2000-09-26 JP JP2001526166A patent/JP2003510274A/en active Pending
- 2000-09-26 IL IL14867000A patent/IL148670A0/en unknown
- 2000-09-26 CZ CZ20021005A patent/CZ303246B6/en not_active IP Right Cessation
- 2000-09-26 EE EEP200200169A patent/EE200200169A/en unknown
- 2000-09-26 WO PCT/EP2000/009390 patent/WO2001022954A2/en active IP Right Grant
- 2000-09-26 MX MXPA02002824A patent/MXPA02002824A/en active IP Right Grant
- 2000-09-26 DE DE50015879T patent/DE50015879D1/en not_active Expired - Lifetime
- 2000-09-28 AR ARP000105105A patent/AR025885A1/en unknown
-
2002
- 2002-03-13 IL IL148670A patent/IL148670A/en not_active IP Right Cessation
- 2002-03-19 NO NO20021367A patent/NO322614B1/en not_active IP Right Cessation
- 2002-03-21 IS IS6319A patent/IS6319A/en unknown
- 2002-04-02 ZA ZA200202556A patent/ZA200202556B/en unknown
- 2002-04-23 BG BG106639A patent/BG106639A/en unknown
- 2002-04-26 HR HR20020369A patent/HRP20020369A2/en not_active Application Discontinuation
-
2003
- 2003-02-18 HK HK03101178.9A patent/HK1048941B/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |