BG106191A - Метод за получаване на циталопрам - Google Patents

Метод за получаване на циталопрам

Info

Publication number
BG106191A
BG106191A BG106191A BG10619101A BG106191A BG 106191 A BG106191 A BG 106191A BG 106191 A BG106191 A BG 106191A BG 10619101 A BG10619101 A BG 10619101A BG 106191 A BG106191 A BG 106191A
Authority
BG
Bulgaria
Prior art keywords
citalopram
preparation
palladium catalyst
halogen
reaction
Prior art date
Application number
BG106191A
Other languages
English (en)
Other versions
BG65574B1 (bg
Inventor
Hans Petersen
Michael Rock
Henrik Svane
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of BG106191A publication Critical patent/BG106191A/bg
Publication of BG65574B1 publication Critical patent/BG65574B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

Методът включва взаимодействие на съединение с формула, в която R е халоген или CF3-(CF2)n-SO2-O-, като n има стойност от 0 до 8, с цианиден източникв присъствието на паладиев катализатор и на каталитично количество Cu+ или Zn2+, или с Zn(CN)2 в присъствието на паладиев катализатор.
BG106191A 1999-06-25 2001-12-07 Метод за получаване на циталопрам BG65574B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199900920 1999-06-25
PCT/DK1999/000640 WO2000013648A2 (en) 1999-06-25 1999-11-22 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
BG106191A true BG106191A (bg) 2002-08-30
BG65574B1 BG65574B1 (bg) 2009-01-30

Family

ID=8099035

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106191A BG65574B1 (bg) 1999-06-25 2001-12-07 Метод за получаване на циталопрам

Country Status (36)

Country Link
US (2) US20020077353A1 (bg)
EP (1) EP1159274B1 (bg)
JP (1) JP3447267B2 (bg)
KR (1) KR100491368B1 (bg)
CN (2) CN1140521C (bg)
AR (1) AR020863A1 (bg)
AT (3) ATE235478T1 (bg)
AU (2) AU2001100440B4 (bg)
BG (1) BG65574B1 (bg)
BR (1) BR9917368B1 (bg)
CA (2) CA2290127C (bg)
CH (1) CH691305A5 (bg)
CZ (1) CZ292198B6 (bg)
DE (2) DE69906389T2 (bg)
DK (2) DK1159274T3 (bg)
EA (1) EA002560B1 (bg)
ES (2) ES2189699A1 (bg)
FI (1) FI108641B (bg)
GB (2) GB2357761B (bg)
HK (1) HK1049002B (bg)
HU (1) HUP0103235A3 (bg)
IL (2) IL145959A0 (bg)
IS (1) IS2343B (bg)
IT (1) ITMI991581A1 (bg)
MX (1) MXPA01010989A (bg)
NO (1) NO328542B1 (bg)
NZ (1) NZ514979A (bg)
PL (1) PL205579B1 (bg)
PT (1) PT1159274E (bg)
SE (1) SE516690C2 (bg)
SI (1) SI1159274T1 (bg)
SK (1) SK285813B6 (bg)
TR (1) TR200103702T2 (bg)
UA (1) UA63034C2 (bg)
WO (1) WO2000013648A2 (bg)
ZA (1) ZA200108854B (bg)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2356188C (en) 1998-12-23 2006-05-23 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2229774T3 (es) 1999-10-25 2005-04-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
DE69920526T2 (de) 1999-10-25 2006-02-23 H. Lundbeck A/S Verfahren zur herstellung von citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
SI1246812T1 (en) 1999-12-28 2004-08-31 H. Lundbeck A/S Method for the preparation of citalopram
HUP0203840A3 (en) 1999-12-30 2005-02-28 Lundbeck & Co As H Method for the preparation of citalopram
IL150561A0 (en) 2000-01-14 2003-02-12 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CN1429219A (zh) 2000-03-13 2003-07-09 H·隆德贝克有限公司 制备西酞普兰的方法
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
CA2402553A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
ATE257832T1 (de) 2000-03-14 2004-01-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
TR200202168T2 (tr) * 2000-03-16 2002-12-23 H. Lundbeck A/S 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
AU2001272368A1 (en) * 2000-07-06 2002-01-21 H. Lundbeck, A/S Method for the preparation of citalopram
FI20011621A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
EA003581B1 (ru) * 2000-12-22 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама
EA003459B1 (ru) * 2000-12-28 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама
CA2435925A1 (en) 2001-01-30 2002-08-08 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
JP2005500256A (ja) * 2001-03-09 2005-01-06 ランバクシー ラボラトリーズ リミテッド シタロプラム製造方法
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
TWI306846B (en) 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1486492A3 (en) 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2006021971A2 (en) 2004-08-23 2006-03-02 Sun Pharmaceutical Industries Limited 'process for preparation of citalopram and enantiomers'
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (bg) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) * 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) * 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) * 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DK1015416T3 (da) * 1997-07-08 2001-11-05 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EA002770B1 (ru) * 1997-11-11 2002-08-29 Х.Лундбекк А/С Способ получения циталопрама
KR100411505B1 (ko) * 1998-10-20 2003-12-18 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
CA2356188C (en) * 1998-12-23 2006-05-23 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) * 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2229774T3 (es) * 1999-10-25 2005-04-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) * 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
FI20011621A (fi) * 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
EA003581B1 (ru) * 2000-12-22 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама
EA003459B1 (ru) * 2000-12-28 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама

Also Published As

Publication number Publication date
GB0105182D0 (en) 2001-04-18
CN1502616A (zh) 2004-06-09
FI20010155A (fi) 2001-02-09
CA2475401A1 (en) 2000-12-25
HUP0103235A2 (hu) 2002-01-28
NO20010319L (no) 2001-02-23
EA200101072A1 (ru) 2002-02-28
ATE235478T1 (de) 2003-04-15
GB2354239A (en) 2001-03-21
NZ514979A (en) 2004-01-30
DE69906389T2 (de) 2003-10-30
AU2001100440A4 (en) 2001-11-01
IS5861A (is) 2001-02-23
SI1159274T1 (en) 2003-10-31
EP1159274A2 (en) 2001-12-05
CN1367786A (zh) 2002-09-04
PL346237A1 (en) 2002-01-28
NO328542B1 (no) 2010-03-15
HK1049002A1 (en) 2003-04-25
SE516690C2 (sv) 2002-02-12
KR20020012204A (ko) 2002-02-15
EP1159274B1 (en) 2003-03-26
DK1159274T3 (da) 2003-07-21
DE19983487C1 (de) 2002-07-25
SK285813B6 (sk) 2007-08-02
GB0101504D0 (en) 2001-03-07
NO20010319D0 (no) 2001-01-19
AT4365U1 (de) 2001-06-25
WO2000013648A2 (en) 2000-03-16
WO2000013648A8 (en) 2000-05-11
CA2290127A1 (en) 2000-12-25
IL145959A (en) 2007-07-24
UA63034C2 (en) 2004-01-15
EA002560B1 (ru) 2002-06-27
SE0100193D0 (sv) 2001-01-24
ES2194545T3 (es) 2003-11-16
MXPA01010989A (es) 2002-06-04
CZ2001320A3 (en) 2001-05-16
CA2290127C (en) 2005-01-25
DE69906389D1 (de) 2003-04-30
BG65574B1 (bg) 2009-01-30
JP3447267B2 (ja) 2003-09-16
HK1049002B (zh) 2004-12-31
IS2343B (is) 2008-02-15
AU1374500A (en) 2000-03-27
IL145959A0 (en) 2002-07-25
KR100491368B1 (ko) 2005-05-24
PL205579B1 (pl) 2010-05-31
ATA904199A (de) 2002-05-15
SE0100193L (sv) 2001-04-25
ES2189699A1 (es) 2003-07-01
GB2357761B (en) 2001-09-05
HUP0103235A3 (en) 2003-01-28
GB2357761A (en) 2001-07-04
ZA200108854B (en) 2002-08-28
FI108641B (fi) 2002-02-28
US20090088469A1 (en) 2009-04-02
CN1140521C (zh) 2004-03-03
US20020077353A1 (en) 2002-06-20
GB2354239B (en) 2001-06-06
TR200103702T2 (tr) 2002-06-21
ITMI991581A1 (it) 2001-01-15
CZ292198B6 (cs) 2003-08-13
JP2002526386A (ja) 2002-08-20
BR9917368B1 (pt) 2010-02-09
WO2000013648B1 (en) 2001-03-15
ITMI991581A0 (it) 1999-07-15
PT1159274E (pt) 2003-08-29
WO2000013648A3 (en) 2000-07-13
AR020863A1 (es) 2002-05-29
DK200100060A (da) 2001-04-10
CH691305A5 (de) 2001-06-29
AT409961B (de) 2002-12-27
SK18402001A3 (sk) 2002-06-04
BR9917368A (pt) 2002-03-05
AU2001100440B4 (en) 2002-01-24

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