BG102789A - Пиримидо/5,4-d/пиримидини, лекарствени средства, съдържащи тези съединения, приложението им и методза тяхното получаване - Google Patents
Пиримидо/5,4-d/пиримидини, лекарствени средства, съдържащи тези съединения, приложението им и методза тяхното получаванеInfo
- Publication number
- BG102789A BG102789A BG102789A BG10278998A BG102789A BG 102789 A BG102789 A BG 102789A BG 102789 A BG102789 A BG 102789A BG 10278998 A BG10278998 A BG 10278998A BG 102789 A BG102789 A BG 102789A
- Authority
- BG
- Bulgaria
- Prior art keywords
- preparation
- application
- pyrimidines
- parimido
- forms containing
- Prior art date
Links
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940093915 gynecological organic acid Drugs 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- JOZPEVMCAKXSEY-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine Chemical class N1=CN=CC2=NC=NC=C21 JOZPEVMCAKXSEY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Пиримидо[5,4-d]-пиримидините проявяват ценни фармакологични свойства, по-специално потискат сигналната трансдукция, осъществяваща се чрез тирозинкинази. Те са с обща формула, в която значенията на Ra-Rc са посочени в претенция 1 в описанието. Изобретението се отнася и до тавтомери, стереоизомери и соли на посочените съединения, по-специално техни физиологично приемливи соли с неорганични или органични киселини или бази, а също и до приложението им за лечение на болести, по-специално на тумори, и до тяхното получаване.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19608588A DE19608588A1 (de) | 1996-03-06 | 1996-03-06 | Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| PCT/EP1997/001047 WO1997032880A1 (de) | 1996-03-06 | 1997-03-03 | PYRIMIDO[5,4-d]PYRIMIDINE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG102789A true BG102789A (bg) | 1999-09-30 |
| BG63163B1 BG63163B1 (bg) | 2001-05-31 |
Family
ID=7787345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102789A BG63163B1 (bg) | 1996-03-06 | 1998-09-24 | Пиримидо/5,4-d/пиримидини, лекарствени средства, съдържащи тези съединения, приложението им и методза тяхното получаване |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5821240A (bg) |
| EP (1) | EP0888351B1 (bg) |
| JP (1) | JP2000506151A (bg) |
| KR (1) | KR19990087504A (bg) |
| CN (1) | CN1064362C (bg) |
| AR (1) | AR006108A1 (bg) |
| AT (1) | ATE252101T1 (bg) |
| AU (1) | AU730376B2 (bg) |
| BG (1) | BG63163B1 (bg) |
| BR (1) | BR9707839A (bg) |
| CA (1) | CA2248720A1 (bg) |
| CO (1) | CO4650043A1 (bg) |
| CZ (1) | CZ281598A3 (bg) |
| DE (2) | DE19608588A1 (bg) |
| EE (1) | EE9800278A (bg) |
| HK (1) | HK1018450A1 (bg) |
| HU (1) | HUP9902049A3 (bg) |
| IL (1) | IL125342A0 (bg) |
| MX (1) | MX9807073A (bg) |
| NO (1) | NO311522B1 (bg) |
| NZ (1) | NZ331545A (bg) |
| PL (1) | PL328719A1 (bg) |
| RU (1) | RU2195461C2 (bg) |
| SK (1) | SK120898A3 (bg) |
| TR (1) | TR199801755T2 (bg) |
| TW (1) | TW454008B (bg) |
| UA (1) | UA54421C2 (bg) |
| UY (1) | UY24474A1 (bg) |
| WO (1) | WO1997032880A1 (bg) |
| ZA (1) | ZA971887B (bg) |
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| SK285141B6 (sk) | 1996-02-13 | 2006-07-07 | Astrazeneca Uk Limited | Použitie chinazolínového derivátu, chinazolínový derivát, spôsob jeho prípravy a farmaceutická kompozícia, ktorá ho obsahuje |
| KR100489174B1 (ko) | 1996-03-05 | 2005-09-30 | 제네카-파마 소시에떼아노님 | 4-아닐리노퀴나졸린유도체 |
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| JP3270834B2 (ja) * | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
| ATE398120T1 (de) | 1999-11-05 | 2008-07-15 | Astrazeneca Ab | Neue quinazolin-derivate |
| EP1170011A1 (en) * | 2000-07-06 | 2002-01-09 | Boehringer Ingelheim International GmbH | Novel use of inhibitors of the epidermal growth factor receptor |
| DE10115921A1 (de) * | 2001-03-30 | 2002-10-02 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von 4,6-Diaminopyrimido[5,4-d]pyrimidinen |
| EP1300146A1 (en) * | 2001-10-03 | 2003-04-09 | Boehringer Ingelheim International GmbH | Pharmaceutical composition for the treatment of animal mammary tumors |
| EP1460061A4 (en) * | 2001-12-27 | 2006-05-31 | Toray Finechemicals Co Ltd | PROCESS FOR PRODUCING 1-ALCOXYCARBONYL SATURATED NITROGENIC HETEROCYCLIC DERIVATIVE |
| US20070179161A1 (en) * | 2003-03-31 | 2007-08-02 | Vernalis (Cambridge) Limited. | Pyrazolopyrimidine compounds and their use in medicine |
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| JO3088B1 (ar) * | 2004-12-08 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
| NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
| KR101139038B1 (ko) | 2005-06-28 | 2012-05-02 | 삼성전자주식회사 | 피리미도피리미딘 유도체 및 이를 이용한 유기 박막 트랜지스터 |
| AU2007274284B2 (en) | 2006-07-13 | 2012-04-26 | Janssen Pharmaceutica N.V. | Mtki quinazoline derivatives |
| CA2687909C (en) * | 2007-06-21 | 2015-09-15 | Janssen Pharmaceutica Nv | Indolin-2-ones and aza-indolin-2-ones |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3049207A1 (de) * | 1980-12-27 | 1982-07-29 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel |
| DE4431867A1 (de) * | 1994-09-07 | 1996-03-14 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| TW414798B (en) * | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
-
1996
- 1996-03-06 DE DE19608588A patent/DE19608588A1/de not_active Ceased
-
1997
- 1997-02-28 UY UY24474A patent/UY24474A1/es not_active Application Discontinuation
- 1997-03-03 HU HU9902049A patent/HUP9902049A3/hu not_active Application Discontinuation
- 1997-03-03 PL PL97328719A patent/PL328719A1/xx unknown
- 1997-03-03 IL IL12534297A patent/IL125342A0/xx unknown
- 1997-03-03 WO PCT/EP1997/001047 patent/WO1997032880A1/de not_active Application Discontinuation
- 1997-03-03 CN CN97192784A patent/CN1064362C/zh not_active Expired - Fee Related
- 1997-03-03 EE EE9800278A patent/EE9800278A/xx unknown
- 1997-03-03 EP EP97906152A patent/EP0888351B1/de not_active Expired - Lifetime
- 1997-03-03 UA UA98105276A patent/UA54421C2/uk unknown
- 1997-03-03 AT AT97906152T patent/ATE252101T1/de not_active IP Right Cessation
- 1997-03-03 RU RU98118380/04A patent/RU2195461C2/ru not_active IP Right Cessation
- 1997-03-03 KR KR1019980706935A patent/KR19990087504A/ko not_active Application Discontinuation
- 1997-03-03 CA CA002248720A patent/CA2248720A1/en not_active Abandoned
- 1997-03-03 NZ NZ331545A patent/NZ331545A/xx unknown
- 1997-03-03 BR BR9707839A patent/BR9707839A/pt not_active Application Discontinuation
- 1997-03-03 JP JP9531440A patent/JP2000506151A/ja not_active Ceased
- 1997-03-03 CZ CZ982815A patent/CZ281598A3/cs unknown
- 1997-03-03 AU AU20945/97A patent/AU730376B2/en not_active Ceased
- 1997-03-03 SK SK1208-98A patent/SK120898A3/sk unknown
- 1997-03-03 TR TR1998/01755T patent/TR199801755T2/xx unknown
- 1997-03-03 DE DE59710864T patent/DE59710864D1/de not_active Expired - Fee Related
- 1997-03-05 ZA ZA971887A patent/ZA971887B/xx unknown
- 1997-03-05 US US08/811,907 patent/US5821240A/en not_active Expired - Lifetime
- 1997-03-05 AR ARP970100873A patent/AR006108A1/es unknown
- 1997-03-06 TW TW086102755A patent/TW454008B/zh not_active IP Right Cessation
- 1997-03-06 CO CO97012277A patent/CO4650043A1/es unknown
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1998
- 1998-08-31 MX MX9807073A patent/MX9807073A/es not_active IP Right Cessation
- 1998-09-04 NO NO19984082A patent/NO311522B1/no not_active IP Right Cessation
- 1998-09-24 BG BG102789A patent/BG63163B1/bg unknown
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1999
- 1999-08-10 HK HK99103458A patent/HK1018450A1/xx not_active IP Right Cessation
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