ES2018726A6 - Procedimiento para preparar derivdos de mitomicina. - Google Patents

Procedimiento para preparar derivdos de mitomicina.

Info

Publication number
ES2018726A6
ES2018726A6 ES8902910A ES8902910A ES2018726A6 ES 2018726 A6 ES2018726 A6 ES 2018726A6 ES 8902910 A ES8902910 A ES 8902910A ES 8902910 A ES8902910 A ES 8902910A ES 2018726 A6 ES2018726 A6 ES 2018726A6
Authority
ES
Spain
Prior art keywords
processes
preparation
bone marrow
reduced bone
marrow toxicity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8902910A
Other languages
English (en)
Inventor
Abdolhossen Talebian
Diana Green
Charles Hammer
Philip S Schein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University filed Critical Georgetown University
Publication of ES2018726A6 publication Critical patent/ES2018726A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE MITOMICINA DE FORMULA: FORMULA DONDE N ES 0, Y ES GLUCOPIRANOSILO, GALACTOPIRANOSILO, MANOPIRANOSILO, XILOPIRANOSILO, CELOBIOSILO, LACTOSILO, GLUCOFURANOSILO, MALTOSILO O 1,3-CICLOHEXANODIOL-2-ILO; O SUS DERIVADOS DE PERACETATO PROTEGIDOS N HIDROXILO, R ES HIDROGENO, RBS1 ES HIDROGENO, ALQUILO CSI1-CSI4 O ALQUILO CSI1-CSI4 SUSTITUIDO CON FENILO, HIDROXIFENILO, INDOLILO, MERCAPTO, ALQUILTIO CSI1-CSI4, HIDROXI, CARBOXI, AMINO, GUANIDINO, IMIDAZOL O CARBAMILO, O R Y RBS1 FORMAN UN ANILLO DE CINCO O SEIS MIEMBROS QUE CONTIENE NITROGENO. CONSISTE EN HACER REACCIONAR MITOMICINA A CON UN COMPUESTO AMINICO, EN CONDICIONES BASICAS, EN UN DISOLVENTE ORGANICO POLAR, PARA DAR EL DERIVADO DE MITOMICINA DESEADO. OTRAS FORMAS DE PREPARACION DE ESTOS DERIVADOS SE DESCRIBEN EN LA MEMORIA. LOS PRODUCTOS OBTENIDOS SON UTILES PARA TRATAR ENFERMEDADES BACTERIANAS Y CANCEROSAS.
ES8902910A 1988-08-23 1989-08-22 Procedimiento para preparar derivdos de mitomicina. Expired - Lifetime ES2018726A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23522488A 1988-08-23 1988-08-23

Publications (1)

Publication Number Publication Date
ES2018726A6 true ES2018726A6 (es) 1991-05-01

Family

ID=22884628

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8902910A Expired - Lifetime ES2018726A6 (es) 1988-08-23 1989-08-22 Procedimiento para preparar derivdos de mitomicina.

Country Status (16)

Country Link
EP (1) EP0431008A4 (es)
JP (1) JPH04500513A (es)
KR (1) KR900701269A (es)
CN (1) CN1040593A (es)
AU (1) AU628846B2 (es)
CA (1) CA1327037C (es)
DK (1) DK29691A (es)
ES (1) ES2018726A6 (es)
GR (1) GR1000785B (es)
IE (1) IE63036B1 (es)
IL (1) IL91332A0 (es)
NO (1) NO177673C (es)
NZ (1) NZ230343A (es)
PT (1) PT91499B (es)
WO (1) WO1990001931A1 (es)
ZA (1) ZA896025B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
EP0485904B1 (en) * 1990-11-13 1997-08-20 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
CN104231045B (zh) * 2014-08-22 2017-10-31 亚飞（上海）生物医药科技有限公司 一种靶向激活释放的丝裂霉素衍生物及其用途
US10682371B2 (en) 2014-08-22 2020-06-16 Yafei Shanghai Biolog Medicine Science & Technology Co. Ltd. Small molecule conjugates specifically activated in tumor microenvironment for targeting and use thereof
US9801909B2 (en) 2015-04-06 2017-10-31 The Penn State Research Foundation Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US479130A (en) * 1892-07-19 Rudolf allert
US3226393A (en) * 1962-06-07 1965-12-28 American Cyanamid Co N-substituted derivatives of mitomycin a and mitomycin c
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
US3367945A (en) * 1965-05-18 1968-02-06 Kyowa Hakko Kogyo Kk Thiourea derivatives of mitomycin
JPS5240B2 (es) * 1973-12-17 1977-01-05
JPS5630978A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Novel mitomycin and its preparation
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
US4746746A (en) * 1983-02-07 1988-05-24 University Patents, Inc. Mitomycin analogs
JPS601197A (ja) * 1983-06-17 1985-01-07 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
US4814445A (en) * 1984-09-04 1989-03-21 Bristol-Myers Company Process for preparing mitomycin analogs
EP0197799B1 (en) * 1985-04-10 1990-09-12 Kyowa Hakko Kogyo Kabushiki Kaisha Pharmacologically active mitomycin derivatives
US4720543A (en) * 1985-06-06 1988-01-19 Georgetown University 1a-7-substituted derivatives of mitomycin and uses thereof
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63246336A (ja) * 1986-11-10 1988-10-13 Kyowa Hakko Kogyo Co Ltd マイトマイシン−抗体複合体含有組成物
JPH06335575A (ja) * 1993-05-28 1994-12-06 Tokyo Electric Co Ltd 電気かみそり

Also Published As

Publication number Publication date
IE63036B1 (en) 1995-03-22
EP0431008A1 (en) 1991-06-12
GR890100514A (en) 1991-12-30
CN1040593A (zh) 1990-03-21
CA1327037C (en) 1994-02-15
AU4065089A (en) 1990-03-23
DK29691A (da) 1991-04-23
NO177673C (no) 1995-11-01
ZA896025B (en) 1990-05-30
NZ230343A (en) 1992-01-29
NO177673B (no) 1995-07-24
JPH04500513A (ja) 1992-01-30
KR900701269A (ko) 1990-12-01
DK29691D0 (da) 1991-02-20
EP0431008A4 (en) 1992-03-11
IL91332A0 (en) 1990-03-19
GR1000785B (el) 1992-12-30
PT91499B (pt) 1995-07-06
NO910662L (no) 1991-03-21
PT91499A (pt) 1990-03-08
IE892691L (en) 1990-02-23
AU628846B2 (en) 1992-09-24
NO910662D0 (no) 1991-02-19
WO1990001931A1 (en) 1990-03-08

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