ZA896025B - Mitomycin derivatives having reduced bone marrow toxicity,processes for their preparation,and the uses thereof - Google Patents

Mitomycin derivatives having reduced bone marrow toxicity,processes for their preparation,and the uses thereof

Info

Publication number
ZA896025B
ZA896025B ZA896025A ZA896025A ZA896025B ZA 896025 B ZA896025 B ZA 896025B ZA 896025 A ZA896025 A ZA 896025A ZA 896025 A ZA896025 A ZA 896025A ZA 896025 B ZA896025 B ZA 896025B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
bone marrow
reduced bone
marrow toxicity
Prior art date
Application number
ZA896025A
Other languages
English (en)
Inventor
Abdolhossen Talebian
Talebian Abdolhossen
Dianna Green
Green Dianna
Charles Hammer
Hammer Charles
Philip S Schein
S Schein Philip
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Publication of ZA896025B publication Critical patent/ZA896025B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA896025A 1988-08-23 1989-08-08 Mitomycin derivatives having reduced bone marrow toxicity,processes for their preparation,and the uses thereof ZA896025B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23522488A 1988-08-23 1988-08-23

Publications (1)

Publication Number Publication Date
ZA896025B true ZA896025B (en) 1990-05-30

Family

ID=22884628

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA896025A ZA896025B (en) 1988-08-23 1989-08-08 Mitomycin derivatives having reduced bone marrow toxicity,processes for their preparation,and the uses thereof

Country Status (16)

Country Link
EP (1) EP0431008A4 (es)
JP (1) JPH04500513A (es)
KR (1) KR900701269A (es)
CN (1) CN1040593A (es)
AU (1) AU628846B2 (es)
CA (1) CA1327037C (es)
DK (1) DK29691A (es)
ES (1) ES2018726A6 (es)
GR (1) GR1000785B (es)
IE (1) IE63036B1 (es)
IL (1) IL91332A0 (es)
NO (1) NO177673C (es)
NZ (1) NZ230343A (es)
PT (1) PT91499B (es)
WO (1) WO1990001931A1 (es)
ZA (1) ZA896025B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
EP0485904B1 (en) * 1990-11-13 1997-08-20 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
CN104231045B (zh) * 2014-08-22 2017-10-31 亚飞（上海）生物医药科技有限公司 一种靶向激活释放的丝裂霉素衍生物及其用途
CA2958495C (en) * 2014-08-22 2023-04-18 Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd. Small molecule conjugates specifically activated in tumor microenvironment for targeting and use thereof
US9801909B2 (en) 2015-04-06 2017-10-31 The Penn State Research Foundation Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US479130A (en) * 1892-07-19 Rudolf allert
US3226393A (en) * 1962-06-07 1965-12-28 American Cyanamid Co N-substituted derivatives of mitomycin a and mitomycin c
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
US3367945A (en) * 1965-05-18 1968-02-06 Kyowa Hakko Kogyo Kk Thiourea derivatives of mitomycin
JPS5240B2 (es) * 1973-12-17 1977-01-05
JPS5630978A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Novel mitomycin and its preparation
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
US4746746A (en) * 1983-02-07 1988-05-24 University Patents, Inc. Mitomycin analogs
JPS601197A (ja) * 1983-06-17 1985-01-07 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
US4814445A (en) * 1984-09-04 1989-03-21 Bristol-Myers Company Process for preparing mitomycin analogs
DE3674043D1 (de) * 1985-04-10 1990-10-18 Kyowa Hakko Kogyo Kk Pharmakologisch aktive mitomycinderivate.
US4720543A (en) * 1985-06-06 1988-01-19 Georgetown University 1a-7-substituted derivatives of mitomycin and uses thereof
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63246336A (ja) * 1986-11-10 1988-10-13 Kyowa Hakko Kogyo Co Ltd マイトマイシン−抗体複合体含有組成物
JPH06335575A (ja) * 1993-05-28 1994-12-06 Tokyo Electric Co Ltd 電気かみそり

Also Published As

Publication number Publication date
IE892691L (en) 1990-02-23
NO910662D0 (no) 1991-02-19
IL91332A0 (en) 1990-03-19
EP0431008A4 (en) 1992-03-11
GR1000785B (el) 1992-12-30
NO177673B (no) 1995-07-24
JPH04500513A (ja) 1992-01-30
ES2018726A6 (es) 1991-05-01
NO177673C (no) 1995-11-01
EP0431008A1 (en) 1991-06-12
WO1990001931A1 (en) 1990-03-08
GR890100514A (en) 1991-12-30
AU4065089A (en) 1990-03-23
CA1327037C (en) 1994-02-15
AU628846B2 (en) 1992-09-24
PT91499A (pt) 1990-03-08
IE63036B1 (en) 1995-03-22
PT91499B (pt) 1995-07-06
NO910662L (no) 1991-03-21
CN1040593A (zh) 1990-03-21
KR900701269A (ko) 1990-12-01
DK29691A (da) 1991-04-23
DK29691D0 (da) 1991-02-20
NZ230343A (en) 1992-01-29

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