PT91499A - Processo para a preparacao de derivados de mitomicina tendo reduzida toxicidade relativamente a medula ossea - Google Patents

Processo para a preparacao de derivados de mitomicina tendo reduzida toxicidade relativamente a medula ossea

Info

Publication number
PT91499A
PT91499A PT91499A PT9149989A PT91499A PT 91499 A PT91499 A PT 91499A PT 91499 A PT91499 A PT 91499A PT 9149989 A PT9149989 A PT 9149989A PT 91499 A PT91499 A PT 91499A
Authority
PT
Portugal
Prior art keywords
medula
ossea
preparation
reduced toxicity
mitomycin derivatives
Prior art date
Application number
PT91499A
Other languages
English (en)
Other versions
PT91499B (pt
Inventor
Abdolhossen Talebian
Dianna Green
Charles Hammer
Philip S Schein
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Publication of PT91499A publication Critical patent/PT91499A/pt
Publication of PT91499B publication Critical patent/PT91499B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT91499A 1988-08-23 1989-08-21 Processo para a preparacao de derivados de mitomicina tendo reduzida toxicidade relativamente a medula ossea PT91499B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23522488A 1988-08-23 1988-08-23

Publications (2)

Publication Number Publication Date
PT91499A true PT91499A (pt) 1990-03-08
PT91499B PT91499B (pt) 1995-07-06

Family

ID=22884628

Family Applications (1)

Application Number Title Priority Date Filing Date
PT91499A PT91499B (pt) 1988-08-23 1989-08-21 Processo para a preparacao de derivados de mitomicina tendo reduzida toxicidade relativamente a medula ossea

Country Status (16)

Country Link
EP (1) EP0431008A4 (pt)
JP (1) JPH04500513A (pt)
KR (1) KR900701269A (pt)
CN (1) CN1040593A (pt)
AU (1) AU628846B2 (pt)
CA (1) CA1327037C (pt)
DK (1) DK29691A (pt)
ES (1) ES2018726A6 (pt)
GR (1) GR1000785B (pt)
IE (1) IE63036B1 (pt)
IL (1) IL91332A0 (pt)
NO (1) NO177673C (pt)
NZ (1) NZ230343A (pt)
PT (1) PT91499B (pt)
WO (1) WO1990001931A1 (pt)
ZA (1) ZA896025B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
EP0485904B1 (en) * 1990-11-13 1997-08-20 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
CN104231045B (zh) * 2014-08-22 2017-10-31 亚飞（上海）生物医药科技有限公司 一种靶向激活释放的丝裂霉素衍生物及其用途
CN106715457B (zh) * 2014-08-22 2021-09-28 亚飞（上海）生物医药科技有限公司 一种肿瘤微环境特异激活的小分子靶向偶联体及其用途
US9801909B2 (en) 2015-04-06 2017-10-31 The Penn State Research Foundation Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US479130A (en) * 1892-07-19 Rudolf allert
US3226393A (en) * 1962-06-07 1965-12-28 American Cyanamid Co N-substituted derivatives of mitomycin a and mitomycin c
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
US3367945A (en) * 1965-05-18 1968-02-06 Kyowa Hakko Kogyo Kk Thiourea derivatives of mitomycin
JPS5240B2 (pt) * 1973-12-17 1977-01-05
JPS5630978A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Novel mitomycin and its preparation
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
US4746746A (en) * 1983-02-07 1988-05-24 University Patents, Inc. Mitomycin analogs
JPS601197A (ja) * 1983-06-17 1985-01-07 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
US4814445A (en) * 1984-09-04 1989-03-21 Bristol-Myers Company Process for preparing mitomycin analogs
JPH066591B2 (ja) * 1985-04-10 1994-01-26 協和醗酵工業株式会社 マイトマイシン誘導体及び抗腫瘍剤
US4720543A (en) * 1985-06-06 1988-01-19 Georgetown University 1a-7-substituted derivatives of mitomycin and uses thereof
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63246336A (ja) * 1986-11-10 1988-10-13 Kyowa Hakko Kogyo Co Ltd マイトマイシン−抗体複合体含有組成物
JPH06335575A (ja) * 1993-05-28 1994-12-06 Tokyo Electric Co Ltd 電気かみそり

Also Published As

Publication number Publication date
PT91499B (pt) 1995-07-06
IE63036B1 (en) 1995-03-22
NO910662L (no) 1991-03-21
AU628846B2 (en) 1992-09-24
IL91332A0 (en) 1990-03-19
GR1000785B (el) 1992-12-30
CA1327037C (en) 1994-02-15
ES2018726A6 (es) 1991-05-01
DK29691A (da) 1991-04-23
KR900701269A (ko) 1990-12-01
IE892691L (en) 1990-02-23
EP0431008A1 (en) 1991-06-12
ZA896025B (en) 1990-05-30
NO177673C (no) 1995-11-01
JPH04500513A (ja) 1992-01-30
NO910662D0 (no) 1991-02-19
DK29691D0 (da) 1991-02-20
EP0431008A4 (en) 1992-03-11
CN1040593A (zh) 1990-03-21
AU4065089A (en) 1990-03-23
NZ230343A (en) 1992-01-29
WO1990001931A1 (en) 1990-03-08
NO177673B (no) 1995-07-24
GR890100514A (en) 1991-12-30

Similar Documents

Publication Publication Date Title
PT98638A (pt) Processo para a preparacao de derivados de borsolina
PT82710B (pt) Processo para a preparacao de derivados la-7-substituidos de mitomicina
PT91216A (pt) Um processo para a preparacao de olefino-sulfonatos internos
PT93785A (pt) Processo para a preparacao de derivados de 3-substituido-2-oxindole
PT91188A (pt) Processo para a preparacao de derivados de furano
PT90523A (pt) Processo para a preparacao de adsorvatos de ranitidina
PT90708A (pt) Processo para a preparacao de derivados de benzopirano
PT89780A (pt) Processo para a preparacao de derivados da tetrahidroisoquinolina
PT89482A (pt) Processo para a preparacao de derivados de nucleosidos disesoxi-didesidro-carboxilico
PT89922A (pt) Processo para a preparacao de derivados da tiazolidenodiona
PT90914A (pt) Processo para a preparacao de derivados de benzazepinae benzotiazapina
PT89545A (pt) Processo para a preparacao de derivados da isoquinolinona
PT88180A (pt) Processo para a preparacao de derivados alquilaminoalcoxifenilo
ES552109A0 (es) Un procedimiento para la preparacion de derivados de aminofenol
PT88340A (pt) Processo para a preparacao de novos derivados de aristeromicina/adenosina
PT93629A (pt) Processo para a preparacao de derivados de tieno-triazolo-diazepina
PT89775A (pt) Processo para a preparacao de derivados de isoquinolina
PT91027A (pt) Processo para a preparacao de derivados peptidicos
PT92539A (pt) Processo para a preparacao de derivados de anfotericina b
PT90593A (pt) Processo para a preparacao de nitrobenzenos
PT91066A (pt) Processo para a preparacao de derivados de eter n-fenilpirazol-4-ilico
PT94008A (pt) Processo para a preparacao de novos derivados de tieno-triazolo-diazepina
PT91499A (pt) Processo para a preparacao de derivados de mitomicina tendo reduzida toxicidade relativamente a medula ossea
PT92808A (pt) Processo para a preparacao de novos derivados de tetralina
PT85608A (pt) Processo para a preparacao de derivados de fenil-etanolamina

Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19990831