PT89545A - Processo para a preparacao de derivados da isoquinolinona - Google Patents

Processo para a preparacao de derivados da isoquinolinona

Info

Publication number
PT89545A
PT89545A PT89545A PT8954589A PT89545A PT 89545 A PT89545 A PT 89545A PT 89545 A PT89545 A PT 89545A PT 8954589 A PT8954589 A PT 8954589A PT 89545 A PT89545 A PT 89545A
Authority
PT
Portugal
Prior art keywords
isokinolinone
derivatives
preparation
isokinolinone derivatives
Prior art date
Application number
PT89545A
Other languages
English (en)
Other versions
PT89545B (pt
Inventor
Andrew William Bridge
Neil Victor Harris
Christopher Smith
David John Lythgoe
Michael John Ashton
Robert Keith Chambers
Donald Ian Dron
Garry Fenton
Ian Michael Mcfarlane
Christopher Gregory Newton
David Riddell
Keith Alfred James Stuttle
Malcolm Percy Toft
Original Assignee
May & Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888801772A external-priority patent/GB8801772D0/en
Priority claimed from GB888819221A external-priority patent/GB8819221D0/en
Application filed by May & Baker Ltd filed Critical May & Baker Ltd
Publication of PT89545A publication Critical patent/PT89545A/pt
Publication of PT89545B publication Critical patent/PT89545B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT89545A 1988-01-27 1989-01-26 Processo para a preparacao de derivados da isoquinolinona PT89545B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888801772A GB8801772D0 (en) 1988-01-27 1988-01-27 Compositions of matter
GB888819221A GB8819221D0 (en) 1988-08-12 1988-08-12 New compositions of matter

Publications (2)

Publication Number Publication Date
PT89545A true PT89545A (pt) 1989-10-04
PT89545B PT89545B (pt) 1994-02-28

Family

ID=26293372

Family Applications (1)

Application Number Title Priority Date Filing Date
PT89545A PT89545B (pt) 1988-01-27 1989-01-26 Processo para a preparacao de derivados da isoquinolinona

Country Status (11)

Country Link
US (1) US5004747A (pt)
EP (1) EP0326386A3 (pt)
JP (1) JPH01242570A (pt)
KR (1) KR890011876A (pt)
AU (1) AU2888289A (pt)
DK (1) DK33789A (pt)
FI (1) FI890393A (pt)
HU (1) HU202842B (pt)
NZ (1) NZ227743A (pt)
OA (1) OA09228A (pt)
PT (1) PT89545B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424929A1 (en) * 1989-10-27 1991-05-02 Takeda Chemical Industries, Ltd. Isoquinolone derivatives, their production and use
EP0510050A1 (en) * 1990-01-08 1992-10-28 Aventis Pharma S.A. Pyran derivatives
DE69110828T2 (de) * 1990-10-16 1995-11-30 Takeda Chemical Industries Ltd Heterozyklische Aminderivate, deren Herstellung und deren Verwendung.
US5162340A (en) * 1991-05-10 1992-11-10 Merck & Co., Inc. Substituted 1-(2h)-isoquinolinones bearing acidic functional groups as angiotensin ii antagonists
US5260316A (en) * 1991-07-30 1993-11-09 Ciba-Geigy Corporation Isoquinolyl substituted hydroxylamine derivatives
US5334600A (en) * 1991-07-30 1994-08-02 Ciba-Geigy Corporation Isoquinolyl substituted hydroxylamine derivatives
US5350761A (en) * 1991-07-30 1994-09-27 Ciba-Geigy Corporation Indolyl substituted hydroxylamine derivatives
JP3141051B2 (ja) * 1992-10-09 2001-03-05 日清製粉株式会社 抗動脈硬化剤
DE4243279A1 (de) * 1992-12-21 1994-06-23 Bayer Ag Substituierte Triole
EP0634402A1 (en) * 1993-07-14 1995-01-18 Takeda Chemical Industries, Ltd. Isochinolinone derivatives, their production and use
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
EP1667978B1 (en) * 2003-09-23 2013-09-04 Merck Sharp & Dohme Corp. Isoquinolinone potassium channel inhibitors
PE20060285A1 (es) * 2004-03-30 2006-05-08 Aventis Pharma Inc Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp)
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
MX2009007831A (es) 2007-01-22 2010-01-15 Gtx Inc Agentes de union de receptor nuclear.
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
US20110136842A1 (en) * 2008-08-06 2011-06-09 Duffy Joseph L Substituted Dihydroisoquinolinone and Isoquinolinedione Derivatives as Calcium Channel Blockers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2098980B (en) * 1981-03-28 1985-05-15 Taiho Pharmaceutical Co Ltd 1(2h)-isoquinolone compounds and acid addition salts thereof
HU204253B (en) * 1982-11-22 1991-12-30 Sandoz Ag Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis

Also Published As

Publication number Publication date
OA09228A (en) 1992-06-30
DK33789D0 (da) 1989-01-26
EP0326386A3 (en) 1990-04-25
DK33789A (da) 1989-07-28
AU2888289A (en) 1989-07-27
HU202842B (en) 1991-04-29
JPH01242570A (ja) 1989-09-27
EP0326386A2 (en) 1989-08-02
NZ227743A (en) 1991-01-29
US5004747A (en) 1991-04-02
HUT50783A (en) 1990-03-28
FI890393A0 (fi) 1989-01-26
KR890011876A (ko) 1989-08-23
PT89545B (pt) 1994-02-28
FI890393A (fi) 1989-07-28

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19930802