IL91332A0 - Mitomycin derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

Mitomycin derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
IL91332A0
IL91332A0 IL91332A IL9133289A IL91332A0 IL 91332 A0 IL91332 A0 IL 91332A0 IL 91332 A IL91332 A IL 91332A IL 9133289 A IL9133289 A IL 9133289A IL 91332 A0 IL91332 A0 IL 91332A0
Authority
IL
Israel
Prior art keywords
processes
preparation
same
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL91332A
Other languages
English (en)
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Priority to IL10543989A priority Critical patent/IL105439A/en
Publication of IL91332A0 publication Critical patent/IL91332A0/xx
Priority to IL105439A priority patent/IL105439A0/xx
Priority to IL105440A priority patent/IL105440A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL91332A 1988-08-23 1989-08-16 Mitomycin derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same IL91332A0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL10543989A IL105439A (en) 1988-08-23 1989-08-16 History of mitomycin A and C are transformed in com AL by the S-chinamyl group transformed in N and processes for their preparation
IL105439A IL105439A0 (en) 1988-08-23 1993-04-18 Mitomycin derivatives and processes for the preparation thereof
IL105440A IL105440A0 (en) 1988-08-23 1993-04-18 Mitomycin derivatives and processes for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23522488A 1988-08-23 1988-08-23

Publications (1)

Publication Number Publication Date
IL91332A0 true IL91332A0 (en) 1990-03-19

Family

ID=22884628

Family Applications (1)

Application Number Title Priority Date Filing Date
IL91332A IL91332A0 (en) 1988-08-23 1989-08-16 Mitomycin derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same

Country Status (16)

Country Link
EP (1) EP0431008A4 (xx)
JP (1) JPH04500513A (xx)
KR (1) KR900701269A (xx)
CN (1) CN1040593A (xx)
AU (1) AU628846B2 (xx)
CA (1) CA1327037C (xx)
DK (1) DK29691A (xx)
ES (1) ES2018726A6 (xx)
GR (1) GR1000785B (xx)
IE (1) IE63036B1 (xx)
IL (1) IL91332A0 (xx)
NO (1) NO177673C (xx)
NZ (1) NZ230343A (xx)
PT (1) PT91499B (xx)
WO (1) WO1990001931A1 (xx)
ZA (1) ZA896025B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
EP0485904B1 (en) * 1990-11-13 1997-08-20 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
CN104231045B (zh) * 2014-08-22 2017-10-31 亚飞（上海）生物医药科技有限公司 一种靶向激活释放的丝裂霉素衍生物及其用途
CN106715457B (zh) * 2014-08-22 2021-09-28 亚飞（上海）生物医药科技有限公司 一种肿瘤微环境特异激活的小分子靶向偶联体及其用途
US9801909B2 (en) 2015-04-06 2017-10-31 The Penn State Research Foundation Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US479130A (en) * 1892-07-19 Rudolf allert
US3226393A (en) * 1962-06-07 1965-12-28 American Cyanamid Co N-substituted derivatives of mitomycin a and mitomycin c
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
US3367945A (en) * 1965-05-18 1968-02-06 Kyowa Hakko Kogyo Kk Thiourea derivatives of mitomycin
JPS5240B2 (xx) * 1973-12-17 1977-01-05
JPS5630978A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Novel mitomycin and its preparation
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
US4746746A (en) * 1983-02-07 1988-05-24 University Patents, Inc. Mitomycin analogs
JPS601197A (ja) * 1983-06-17 1985-01-07 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
US4814445A (en) * 1984-09-04 1989-03-21 Bristol-Myers Company Process for preparing mitomycin analogs
JPH066591B2 (ja) * 1985-04-10 1994-01-26 協和醗酵工業株式会社 マイトマイシン誘導体及び抗腫瘍剤
US4720543A (en) * 1985-06-06 1988-01-19 Georgetown University 1a-7-substituted derivatives of mitomycin and uses thereof
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63246336A (ja) * 1986-11-10 1988-10-13 Kyowa Hakko Kogyo Co Ltd マイトマイシン−抗体複合体含有組成物
JPH06335575A (ja) * 1993-05-28 1994-12-06 Tokyo Electric Co Ltd 電気かみそり

Also Published As

Publication number Publication date
PT91499B (pt) 1995-07-06
IE63036B1 (en) 1995-03-22
NO910662L (no) 1991-03-21
AU628846B2 (en) 1992-09-24
GR1000785B (el) 1992-12-30
CA1327037C (en) 1994-02-15
ES2018726A6 (es) 1991-05-01
DK29691A (da) 1991-04-23
KR900701269A (ko) 1990-12-01
IE892691L (en) 1990-02-23
EP0431008A1 (en) 1991-06-12
ZA896025B (en) 1990-05-30
NO177673C (no) 1995-11-01
JPH04500513A (ja) 1992-01-30
NO910662D0 (no) 1991-02-19
DK29691D0 (da) 1991-02-20
EP0431008A4 (en) 1992-03-11
CN1040593A (zh) 1990-03-21
AU4065089A (en) 1990-03-23
NZ230343A (en) 1992-01-29
WO1990001931A1 (en) 1990-03-08
NO177673B (no) 1995-07-24
GR890100514A (en) 1991-12-30
PT91499A (pt) 1990-03-08

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