EP0431008A4 - Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof - Google Patents

Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof

Info

Publication number
EP0431008A4
EP0431008A4 EP19890909473 EP89909473A EP0431008A4 EP 0431008 A4 EP0431008 A4 EP 0431008A4 EP 19890909473 EP19890909473 EP 19890909473 EP 89909473 A EP89909473 A EP 89909473A EP 0431008 A4 EP0431008 A4 EP 0431008A4
Authority
EP
European Patent Office
Prior art keywords
processes
preparation
bone marrow
reduced bone
marrow toxicity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19890909473
Other languages
English (en)
Other versions
EP0431008A1 (en
Inventor
Abdolhossen Talebian
Diana Green
Charles Hammer
Philip S. Schein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University filed Critical Georgetown University
Publication of EP0431008A1 publication Critical patent/EP0431008A1/en
Publication of EP0431008A4 publication Critical patent/EP0431008A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP19890909473 1988-08-23 1989-07-25 Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof Withdrawn EP0431008A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23522488A 1988-08-23 1988-08-23
US235224 1988-08-23

Publications (2)

Publication Number Publication Date
EP0431008A1 EP0431008A1 (en) 1991-06-12
EP0431008A4 true EP0431008A4 (en) 1992-03-11

Family

ID=22884628

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890909473 Withdrawn EP0431008A4 (en) 1988-08-23 1989-07-25 Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof

Country Status (16)

Country Link
EP (1) EP0431008A4 (es)
JP (1) JPH04500513A (es)
KR (1) KR900701269A (es)
CN (1) CN1040593A (es)
AU (1) AU628846B2 (es)
CA (1) CA1327037C (es)
DK (1) DK29691A (es)
ES (1) ES2018726A6 (es)
GR (1) GR1000785B (es)
IE (1) IE63036B1 (es)
IL (1) IL91332A0 (es)
NO (1) NO177673C (es)
NZ (1) NZ230343A (es)
PT (1) PT91499B (es)
WO (1) WO1990001931A1 (es)
ZA (1) ZA896025B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
EP0485904B1 (en) * 1990-11-13 1997-08-20 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
CN104231045B (zh) * 2014-08-22 2017-10-31 亚飞（上海）生物医药科技有限公司 一种靶向激活释放的丝裂霉素衍生物及其用途
CA2958495C (en) * 2014-08-22 2023-04-18 Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd. Small molecule conjugates specifically activated in tumor microenvironment for targeting and use thereof
US9801909B2 (en) 2015-04-06 2017-10-31 The Penn State Research Foundation Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US479130A (en) * 1892-07-19 Rudolf allert
US3226393A (en) * 1962-06-07 1965-12-28 American Cyanamid Co N-substituted derivatives of mitomycin a and mitomycin c
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
US3367945A (en) * 1965-05-18 1968-02-06 Kyowa Hakko Kogyo Kk Thiourea derivatives of mitomycin
JPS5240B2 (es) * 1973-12-17 1977-01-05
JPS5630978A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Novel mitomycin and its preparation
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
US4746746A (en) * 1983-02-07 1988-05-24 University Patents, Inc. Mitomycin analogs
JPS601197A (ja) * 1983-06-17 1985-01-07 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
US4814445A (en) * 1984-09-04 1989-03-21 Bristol-Myers Company Process for preparing mitomycin analogs
DE3674043D1 (de) * 1985-04-10 1990-10-18 Kyowa Hakko Kogyo Kk Pharmakologisch aktive mitomycinderivate.
US4720543A (en) * 1985-06-06 1988-01-19 Georgetown University 1a-7-substituted derivatives of mitomycin and uses thereof
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63246336A (ja) * 1986-11-10 1988-10-13 Kyowa Hakko Kogyo Co Ltd マイトマイシン−抗体複合体含有組成物
JPH06335575A (ja) * 1993-05-28 1994-12-06 Tokyo Electric Co Ltd 電気かみそり

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 13, no. 49 (C-565)(3397) 3 February 1989 & JP-A-63 246 336 ( KYOWA HAKKO KOGYO CO LTD ) 13 October 1988 *
PATENT ABSTRACTS OF JAPAN vol. 9, no. 108 (C-280)(1831) 11 May 1985 & JP-A-60 001 197 ( KYOWA HAKKO KOGYO K.K. ) 7 January 1985 *
See also references of WO9001931A1 *

Also Published As

Publication number Publication date
IE892691L (en) 1990-02-23
NO910662D0 (no) 1991-02-19
IL91332A0 (en) 1990-03-19
GR1000785B (el) 1992-12-30
NO177673B (no) 1995-07-24
JPH04500513A (ja) 1992-01-30
ES2018726A6 (es) 1991-05-01
NO177673C (no) 1995-11-01
EP0431008A1 (en) 1991-06-12
WO1990001931A1 (en) 1990-03-08
GR890100514A (en) 1991-12-30
AU4065089A (en) 1990-03-23
CA1327037C (en) 1994-02-15
AU628846B2 (en) 1992-09-24
PT91499A (pt) 1990-03-08
ZA896025B (en) 1990-05-30
IE63036B1 (en) 1995-03-22
PT91499B (pt) 1995-07-06
NO910662L (no) 1991-03-21
CN1040593A (zh) 1990-03-21
KR900701269A (ko) 1990-12-01
DK29691A (da) 1991-04-23
DK29691D0 (da) 1991-02-20
NZ230343A (en) 1992-01-29

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19910222

AK Designated contracting states

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A4 Supplementary search report drawn up and despatched

Effective date: 19920120

AK Designated contracting states

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17Q First examination report despatched

Effective date: 19920812

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19940822