BG102632A - Метални комплекси съдържащи перфлуороалкил и използването им при nмr диагностики - Google Patents
Метални комплекси съдържащи перфлуороалкил и използването им при nмr диагностикиInfo
- Publication number
- BG102632A BG102632A BG102632A BG10263298A BG102632A BG 102632 A BG102632 A BG 102632A BG 102632 A BG102632 A BG 102632A BG 10263298 A BG10263298 A BG 10263298A BG 102632 A BG102632 A BG 102632A
- Authority
- BG
- Bulgaria
- Prior art keywords
- application
- perfluoralkyl
- metallic complexes
- containing metallic
- nmr diagnostics
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/14—Linings or internal coatings
- B65D25/16—Loose, or loosely-attached, linings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
- B65D47/08—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages having articulated or hinged closures
- B65D47/0804—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages having articulated or hinged closures integrally formed with the base element provided with the spout or discharge passage
- B65D47/0833—Hinges without elastic bias
- B65D47/0847—Hinges without elastic bias located within a flat surface of the base element
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/0055—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Изобретението се отнася до нови мономери перфлуороалкилзаместени метални комплекси, до метод за тяхното получаване и до приложението им в диагностиката и терапията. Съединенията са особено подходящи за използване като in vivo контрастни средства в ядрено-спинова томография (MRT). Те могат да се използват за предпочитане като blood-pool средства и като средства за лимфография.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19603033A DE19603033A1 (de) | 1996-01-19 | 1996-01-19 | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
PCT/EP1997/000209 WO1997026017A2 (de) | 1996-01-19 | 1997-01-16 | Perfluoralkylhaltige metallkomplexe und ihre verwendung in der nmr-diagnostik |
Publications (2)
Publication Number | Publication Date |
---|---|
BG102632A true BG102632A (bg) | 1999-06-30 |
BG62914B1 BG62914B1 (bg) | 2000-11-30 |
Family
ID=7783921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG102632A BG62914B1 (bg) | 1996-01-19 | 1998-07-15 | Метални комплекси, съдържащи перфлуороалкил, и използването им при nmr диагностики |
Country Status (28)
Country | Link |
---|---|
US (3) | US6468502B1 (bg) |
EP (1) | EP0874645B1 (bg) |
JP (1) | JP2000506511A (bg) |
KR (1) | KR100539041B1 (bg) |
CN (1) | CN1203898C (bg) |
AT (1) | ATE215386T1 (bg) |
AU (1) | AU716788B2 (bg) |
BG (1) | BG62914B1 (bg) |
BR (1) | BR9707053B1 (bg) |
CZ (1) | CZ298769B6 (bg) |
DE (2) | DE19603033A1 (bg) |
DK (1) | DK0874645T3 (bg) |
EE (1) | EE04298B1 (bg) |
ES (1) | ES2174215T3 (bg) |
HK (1) | HK1018404A1 (bg) |
HU (1) | HU226199B1 (bg) |
IL (1) | IL125311A (bg) |
IS (1) | IS2127B (bg) |
NO (1) | NO319680B1 (bg) |
NZ (1) | NZ330579A (bg) |
PL (1) | PL187466B1 (bg) |
PT (1) | PT874645E (bg) |
RU (1) | RU2242477C2 (bg) |
SK (1) | SK283576B6 (bg) |
TW (1) | TW542841B (bg) |
UA (1) | UA65533C2 (bg) |
WO (1) | WO1997026017A2 (bg) |
ZA (1) | ZA97419B (bg) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19603033A1 (de) * | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
UA59384C2 (uk) * | 1996-12-20 | 2003-09-15 | Пфайзер, Інк. | Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі |
DE19729013A1 (de) * | 1997-07-03 | 1999-02-04 | Schering Ag | Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
US6495118B1 (en) * | 1997-09-26 | 2002-12-17 | Schering Aktiengesellschaft | Lipophilic metal complexes for necrosis and infarction imaging |
DE19744004C1 (de) * | 1997-09-26 | 1999-07-22 | Schering Ag | Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging |
DE19914101C1 (de) * | 1999-03-22 | 2000-10-12 | Schering Ag | Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik |
US6461587B1 (en) | 1999-03-22 | 2002-10-08 | Schering Aktiengesellschaft | Perfluoroalkylamides, their production and their use in diagnosis |
DE19948650A1 (de) * | 1999-09-29 | 2001-07-19 | Diagnostikforschung Inst | Galenische Formulierungen |
DE19948651B4 (de) * | 1999-09-29 | 2006-10-05 | Schering Ag | Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung |
EP1088559A3 (de) * | 1999-09-29 | 2002-10-02 | INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN | Galenische Formulierungen |
DE10040858C2 (de) * | 2000-08-11 | 2003-12-18 | Schering Ag | Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung |
US6818203B2 (en) * | 2000-08-11 | 2004-11-16 | Schering Aktiengesellschaft | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses |
US6641797B2 (en) | 2000-08-11 | 2003-11-04 | Schering Aktiengesellschaft | Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use |
DE10040380B4 (de) * | 2000-08-11 | 2006-03-09 | Schering Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques |
DE10066210B4 (de) * | 2000-08-11 | 2008-02-28 | Bayer Schering Pharma Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques |
US6676928B2 (en) | 2000-08-11 | 2004-01-13 | Schering Aktiengesellschaft | Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use |
DE10040381C1 (de) * | 2000-08-11 | 2002-06-06 | Schering Ag | Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung |
DE10135356C1 (de) | 2001-07-20 | 2003-04-17 | Schering Ag | Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen |
CA2456052A1 (en) | 2001-08-03 | 2003-02-20 | Glaxo Group Limited | Surfactant compounds and uses thereof |
NO20015814D0 (no) * | 2001-11-28 | 2001-11-28 | Amersham Health As | Metallkompleksforbindelser |
DE10231799B4 (de) * | 2002-07-10 | 2006-10-05 | Schering Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben |
WO2004006934A2 (de) * | 2002-07-10 | 2004-01-22 | Hans Robert Kalbitzer | 1,4,7,10-tetraazacyclododecane als modulatoren des guanin-nukleotid bindenden roteins zur behandlung von tumoren |
US7344704B2 (en) | 2002-07-10 | 2008-03-18 | Schering Ag | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi |
CN101098916A (zh) | 2005-01-13 | 2008-01-02 | 金文申有限公司 | 含有碳纳米颗粒的复合材料 |
DE102005008309A1 (de) * | 2005-02-17 | 2006-08-24 | Schering Ag | Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone |
DE102005033902B3 (de) * | 2005-07-15 | 2007-04-05 | Schering Ag | Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel |
DE102005033903B4 (de) * | 2005-07-15 | 2007-08-09 | Bayer Schering Pharma Ag | Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel |
DE102006021495A1 (de) * | 2006-05-09 | 2007-11-15 | Bayer Schering Pharma Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit |
WO2007141767A2 (en) * | 2006-06-09 | 2007-12-13 | Koninklijke Philips Electronics N.V. | Elimination of contrast agent concentration dependency in mri |
DE102006049821A1 (de) | 2006-10-18 | 2008-04-24 | Bayer Schering Pharma Aktiengesellschaft | Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung |
GB0708411D0 (en) * | 2007-05-01 | 2007-06-06 | Univ Durham | Lanthanide probes |
WO2010056590A2 (en) * | 2008-11-14 | 2010-05-20 | University Of Maryland, Baltimore | Conjugates of 19f mr imaging tracers for use in multi-chromic mri imaging |
KR20170093888A (ko) * | 2014-12-08 | 2017-08-16 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 하이드로플루오로올레핀 및 그의 사용 방법 |
EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
CN114890941A (zh) | 2015-08-13 | 2022-08-12 | 通用医疗公司 | 用于mr分子成像的基于锰的螯合缀合物 |
WO2018096082A1 (en) | 2016-11-28 | 2018-05-31 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
MX2021006024A (es) | 2018-11-23 | 2021-07-06 | Bayer Ag | Formulacion de medios de contraste y proceso para prepararlos. |
US20200397924A1 (en) * | 2019-01-28 | 2020-12-24 | Hubei Tianshu Pharmaceutical Co., Ltd | Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof |
CN110922365B (zh) * | 2019-12-13 | 2021-04-27 | 山东铂源药业有限公司 | 一种高纯度轮环藤宁的制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US4859584A (en) | 1986-10-31 | 1989-08-22 | Smithkline Beckman Corporation | Cell growth rate determination by measurement of changes in cyanine dye levels in plasma membranes |
US4762701A (en) | 1986-10-31 | 1988-08-09 | Smithkline Beckman Corporation | In vivo cellular tracking |
US5672334A (en) | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
US5114703A (en) * | 1989-05-30 | 1992-05-19 | Alliance Pharmaceutical Corp. | Percutaneous lymphography using particulate fluorocarbon emulsions |
DE3930674A1 (de) * | 1989-09-11 | 1991-03-21 | Diagnostikforschung Inst | Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie |
US5248498A (en) * | 1991-08-19 | 1993-09-28 | Mallinckrodt Medical, Inc. | Fullerene compositions for magnetic resonance spectroscopy and imaging |
JPH06181890A (ja) * | 1992-10-06 | 1994-07-05 | Terumo Corp | Mri造影剤 |
US5401493A (en) * | 1993-03-26 | 1995-03-28 | Molecular Biosystems, Inc. | Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same |
DE4317588C2 (de) * | 1993-05-24 | 1998-04-16 | Schering Ag | Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung |
JPH0797340A (ja) * | 1993-06-03 | 1995-04-11 | Terumo Corp | Mri造影剤組成物 |
DE19603033A1 (de) * | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
US6019959A (en) * | 1997-07-31 | 2000-02-01 | Schering Aktiengesellschaft | Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis |
US6461587B1 (en) * | 1999-03-22 | 2002-10-08 | Schering Aktiengesellschaft | Perfluoroalkylamides, their production and their use in diagnosis |
EP1088559A3 (de) * | 1999-09-29 | 2002-10-02 | INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN | Galenische Formulierungen |
US6818203B2 (en) * | 2000-08-11 | 2004-11-16 | Schering Aktiengesellschaft | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses |
US6641797B2 (en) * | 2000-08-11 | 2003-11-04 | Schering Aktiengesellschaft | Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use |
US6676928B2 (en) * | 2000-08-11 | 2004-01-13 | Schering Aktiengesellschaft | Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use |
-
1996
- 1996-01-19 DE DE19603033A patent/DE19603033A1/de not_active Withdrawn
-
1997
- 1997-01-16 ES ES97902179T patent/ES2174215T3/es not_active Expired - Lifetime
- 1997-01-16 HU HU9901295A patent/HU226199B1/hu not_active IP Right Cessation
- 1997-01-16 RU RU98115579/04A patent/RU2242477C2/ru not_active IP Right Cessation
- 1997-01-16 EP EP97902179A patent/EP0874645B1/de not_active Expired - Lifetime
- 1997-01-16 WO PCT/EP1997/000209 patent/WO1997026017A2/de active IP Right Grant
- 1997-01-16 CZ CZ0226398A patent/CZ298769B6/cs not_active IP Right Cessation
- 1997-01-16 IL IL12531197A patent/IL125311A/en not_active IP Right Cessation
- 1997-01-16 KR KR1019980705523A patent/KR100539041B1/ko not_active IP Right Cessation
- 1997-01-16 SK SK990-98A patent/SK283576B6/sk unknown
- 1997-01-16 DK DK97902179T patent/DK0874645T3/da active
- 1997-01-16 JP JP9525698A patent/JP2000506511A/ja not_active Ceased
- 1997-01-16 CN CNB971917701A patent/CN1203898C/zh not_active Expired - Fee Related
- 1997-01-16 AT AT97902179T patent/ATE215386T1/de not_active IP Right Cessation
- 1997-01-16 DE DE59706863T patent/DE59706863D1/de not_active Expired - Fee Related
- 1997-01-16 EE EE9800204A patent/EE04298B1/xx not_active IP Right Cessation
- 1997-01-16 BR BRPI9707053-0A patent/BR9707053B1/pt not_active IP Right Cessation
- 1997-01-16 PL PL97327931A patent/PL187466B1/pl not_active IP Right Cessation
- 1997-01-16 NZ NZ330579A patent/NZ330579A/xx unknown
- 1997-01-16 AU AU15977/97A patent/AU716788B2/en not_active Ceased
- 1997-01-16 UA UA98084472A patent/UA65533C2/uk unknown
- 1997-01-16 PT PT97902179T patent/PT874645E/pt unknown
- 1997-01-17 ZA ZA9700419A patent/ZA97419B/xx unknown
- 1997-01-18 TW TW086100514A patent/TW542841B/zh not_active IP Right Cessation
-
1998
- 1998-06-30 IS IS4790A patent/IS2127B/xx unknown
- 1998-07-15 BG BG102632A patent/BG62914B1/bg unknown
- 1998-07-16 NO NO19983287A patent/NO319680B1/no unknown
-
1999
- 1999-08-13 HK HK99103506A patent/HK1018404A1/xx not_active IP Right Cessation
- 1999-11-08 US US09/435,918 patent/US6468502B1/en not_active Expired - Fee Related
-
2002
- 2002-07-18 US US10/197,421 patent/US6916461B2/en not_active Expired - Fee Related
-
2004
- 2004-10-05 US US10/957,628 patent/US7226578B2/en not_active Expired - Fee Related
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