BG101591A - Метод за получаване на 1-(2'-дезокси-2',2'-дифлуор-d- рибофуранозил)-4-аминопиримидин-2-он хидрохлорид - Google Patents

Метод за получаване на 1-(2'-дезокси-2',2'-дифлуор-d- рибофуранозил)-4-аминопиримидин-2-он хидрохлорид

Info

Publication number
BG101591A
BG101591A BG101591A BG10159197A BG101591A BG 101591 A BG101591 A BG 101591A BG 101591 A BG101591 A BG 101591A BG 10159197 A BG10159197 A BG 10159197A BG 101591 A BG101591 A BG 101591A
Authority
BG
Bulgaria
Prior art keywords
ribofuranosyl
deoxy
difluoro
preparing
drochloride
Prior art date
Application number
BG101591A
Other languages
English (en)
Other versions
BG62738B1 (bg
Inventor
Richard Berglund
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23397211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG101591(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of BG101591A publication Critical patent/BG101591A/bg
Publication of BG62738B1 publication Critical patent/BG62738B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Методът намира приложение за получаване на гемцитабинов хидрохлорид. Той включва деблокиране на -1-(2'-дезокси-2',2'-дифлуоро-3',5'-ди-0-бензоил-D-рибофуранозил)-4-аминопиримидин-2-он с каталитично количество алкиламин в присъствието на метанол илиетанол в околна среда, по същество свободна от вода, обработване на получения разтвор със солна киселина и антиразтворител и извличане на получения твърд гемцитабинов хидрохлорид.
BG101591A 1994-12-13 1997-06-10 Метод за получаване на 1-(2'-дезокси-2',2'-дифлуор-d- рибофуранозил)-4-аминопиримидин-2-он хидрохлорид BG62738B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/355,372 US5637688A (en) 1994-12-13 1994-12-13 Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
PCT/US1995/014864 WO1996018637A1 (en) 1994-12-13 1995-11-14 Process for preparing 1-(2'-deoxy-2',2'-difluoro-d-ribofuranosyl-4-aminopyrimidin-2-one) hydrochloride

Publications (2)

Publication Number Publication Date
BG101591A true BG101591A (bg) 1998-03-31
BG62738B1 BG62738B1 (bg) 2000-06-30

Family

ID=23397211

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101591A BG62738B1 (bg) 1994-12-13 1997-06-10 Метод за получаване на 1-(2'-дезокси-2',2'-дифлуор-d- рибофуранозил)-4-аминопиримидин-2-он хидрохлорид

Country Status (31)

Country Link
US (2) US5637688A (bg)
EP (1) EP0719788B1 (bg)
JP (1) JPH10510806A (bg)
KR (1) KR100424991B1 (bg)
CN (1) CN1047177C (bg)
AR (1) AR001041A1 (bg)
AT (1) ATE179986T1 (bg)
AU (1) AU689674B2 (bg)
BG (1) BG62738B1 (bg)
BR (1) BR9509979A (bg)
CO (1) CO4520286A1 (bg)
CZ (1) CZ290941B6 (bg)
DE (1) DE69509624T2 (bg)
DK (1) DK0719788T3 (bg)
ES (1) ES2130542T3 (bg)
GR (1) GR3030265T3 (bg)
HU (1) HU219021B (bg)
IL (1) IL115852A (bg)
MY (1) MY112488A (bg)
NO (1) NO306783B1 (bg)
NZ (1) NZ296476A (bg)
PE (1) PE49296A1 (bg)
PL (1) PL181732B1 (bg)
RO (1) RO117327B1 (bg)
RU (1) RU2154648C2 (bg)
SI (1) SI0719788T1 (bg)
TW (1) TW379226B (bg)
UA (1) UA48152C2 (bg)
WO (1) WO1996018637A1 (bg)
YU (1) YU49314B (bg)
ZA (1) ZA959320B (bg)

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US6376470B1 (en) 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
AU2001296558A1 (en) 2000-10-03 2002-04-15 Oncopharmaceutical, Inc. Inhibitors of angiogenesis and tumor growth for local and systemic administration
WO2005014010A1 (en) * 2003-07-24 2005-02-17 Eli Lilly And Company Pharmaceutical composition comprising gemcitabine and cyclodextrines
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
EP1812457A1 (en) * 2004-07-30 2007-08-01 Pharmaessentia Corp. STEREOSELECTIVE SYNTHESIS OF ß-NUCLEOSIDES
WO2006070985A1 (en) * 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
MX2007010316A (es) * 2005-03-04 2008-02-19 Dabur Pharma Ltd Intermediario de 21-desoxi, 21,21-difluoro-d-ribofuranosil nucleosidos enriquecidos en (-anomero y proceso para prepararlo.
WO2006095359A1 (en) * 2005-03-10 2006-09-14 Sms Pharmaceuticals Limited Synthesis of 2-deoxy-2, 2-di fluoro-d-ribo furanose-3, 5 di(4-methy/4-nitro-chloro)benzoate and its conversion to gemcitabine hydrochloride thereof
WO2006119347A1 (en) * 2005-05-02 2006-11-09 Pharmaessentia Corp. STEREOSELECTIVE SYNTHESIS OF β-NUCLEOSIDES
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
JP2009513623A (ja) * 2005-10-28 2009-04-02 アーチ ファーマラブズ リミテッド 塩酸ジェムシタビンの改良された製造方法
KR101259637B1 (ko) * 2005-12-14 2013-04-30 주식회사종근당 1-(2´-데옥시-2´,2´-디플루오로-디-리보푸라노실)-4-아미노피리미딘-2-온또는 그의 염산염의 제조방법
US20090069354A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched gemcitabine
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
US8193339B2 (en) * 2007-11-06 2012-06-05 Pharmaessentia Corp. Synthesis of β-nucleosides
IT1393062B1 (it) * 2008-10-23 2012-04-11 Prime Europ Therapeuticals Procedimento per la preparazione di gemcitabina cloridrato
TWI503121B (zh) * 2009-04-06 2015-10-11 Otsuka Pharma Co Ltd 用以治療癌症之組成物及方法
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
JP5684787B2 (ja) * 2009-04-06 2015-03-18 大塚製薬株式会社 シチジンベースの抗新生物薬とシチジンデアミナーゼ阻害薬との組合せ、および癌の治療におけるその使用
AU2010234637B2 (en) * 2009-04-06 2016-05-12 Otsuka Pharmaceutical Co., Ltd. (2 ' -deoxy-ribofuranosyl) -1,3,4, 7-tetrahydro- (1,3) iazepin-2-0ne derivatives for treating cancer
CN101525361B (zh) * 2009-04-21 2010-11-17 济南圣鲁金药物技术开发有限公司 基于吉西他滨结构的前药及其合成方法及应用
EP2431376B2 (en) * 2009-05-15 2024-02-07 Delta-Fly Pharma, Inc. Novel stable crystal of 1-(2'-cyano-2'-deoxy-beta -d-arabinofuranosyl)cytosine monohydrochloride
CN101628927B (zh) * 2009-08-07 2012-10-10 卡硼瑞（北京）科技有限公司 以1,3,5-三-O-苯甲酰基-α-D-呋喃核糖为原料立体选择性制备β-二氟胞苷盐酸盐的方法
CN102453064B (zh) * 2011-06-30 2014-07-09 江苏豪森药业股份有限公司 制备吉西他滨盐酸盐的方法
CN102659884B (zh) * 2012-04-23 2014-07-02 南京臣功制药股份有限公司 盐酸吉西他滨的提纯方法
CN103224541B (zh) * 2013-04-27 2015-07-01 江苏豪森药业股份有限公司 吉西他滨α-异构体转化回收工艺
CN104402945A (zh) * 2014-11-27 2015-03-11 苏州乔纳森新材料科技有限公司 一种3-脱氧-1,2-o-异丙叉-d-呋喃木糖的合成方法

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US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

Also Published As

Publication number Publication date
CO4520286A1 (es) 1997-10-15
CZ179897A3 (en) 1997-09-17
AU689674B2 (en) 1998-04-02
NO972679D0 (no) 1997-06-11
KR100424991B1 (ko) 2004-05-20
EP0719788B1 (en) 1999-05-12
DE69509624T2 (de) 1999-10-07
CN1169728A (zh) 1998-01-07
PE49296A1 (es) 1996-11-21
MX9704322A (es) 1997-09-30
HU219021B (hu) 2001-01-29
ATE179986T1 (de) 1999-05-15
BG62738B1 (bg) 2000-06-30
JPH10510806A (ja) 1998-10-20
MY112488A (en) 2001-06-30
GR3030265T3 (en) 1999-08-31
RU2154648C2 (ru) 2000-08-20
TW379226B (en) 2000-01-11
UA48152C2 (uk) 2002-08-15
ES2130542T3 (es) 1999-07-01
IL115852A0 (en) 1996-01-31
BR9509979A (pt) 1998-06-09
AU4110196A (en) 1996-07-03
NO972679L (no) 1997-06-11
EP0719788A2 (en) 1996-07-03
PL321046A1 (en) 1997-11-24
SI0719788T1 (en) 1999-10-31
WO1996018637A1 (en) 1996-06-20
CN1047177C (zh) 1999-12-08
IL115852A (en) 1999-09-22
CZ290941B6 (cs) 2002-11-13
US5637688A (en) 1997-06-10
NZ296476A (en) 1998-12-23
DK0719788T3 (da) 1999-11-01
DE69509624D1 (de) 1999-06-17
YU49314B (sh) 2005-06-10
AR001041A1 (es) 1997-09-24
RO117327B1 (ro) 2002-01-30
PL181732B1 (en) 2001-09-28
US5808048A (en) 1998-09-15
NO306783B1 (no) 1999-12-20
HUT77929A (hu) 1998-11-30
YU70895A (sh) 1998-09-18
ZA959320B (en) 1997-05-05
EP0719788A3 (en) 1996-09-25

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