MX2007010316A - Intermediario de 21-desoxi, 21,21-difluoro-d-ribofuranosil nucleosidos enriquecidos en (-anomero y proceso para prepararlo. - Google Patents

Intermediario de 21-desoxi, 21,21-difluoro-d-ribofuranosil nucleosidos enriquecidos en (-anomero y proceso para prepararlo.

Info

Publication number
MX2007010316A
MX2007010316A MX2007010316A MX2007010316A MX2007010316A MX 2007010316 A MX2007010316 A MX 2007010316A MX 2007010316 A MX2007010316 A MX 2007010316A MX 2007010316 A MX2007010316 A MX 2007010316A MX 2007010316 A MX2007010316 A MX 2007010316A
Authority
MX
Mexico
Prior art keywords
21deoxy
difluoro
beta
preparing
anomer enriched
Prior art date
Application number
MX2007010316A
Other languages
English (en)
Inventor
Maikap Golak
Deependra Bhatt
Kumar Panda Bijan
Original Assignee
Dabur Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35457749&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2007010316(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dabur Pharma Ltd filed Critical Dabur Pharma Ltd
Publication of MX2007010316A publication Critical patent/MX2007010316A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se proporciona un proceso de glicosilacion de alta estereoselectividad, simple y economico, para la preparacion de 24-desoxi-21, 21-D-ribofuranosil difluoronucleosidos de formula (II) enriquecidos en anomero ( y las sales fisiologicamente aceptables de los mismos, en particular, la preparacion del anomero enriquecido en la forma ( del clorhidrato de gemcitabina de formula (IIb) con una pureza >99% mediante la utilizacion de un nuevo tricloroacetimidato de formula (I).
MX2007010316A 2005-03-04 2005-09-23 Intermediario de 21-desoxi, 21,21-difluoro-d-ribofuranosil nucleosidos enriquecidos en (-anomero y proceso para prepararlo. MX2007010316A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN472DE2005 2005-03-04
PCT/IN2005/000322 WO2006092808A1 (en) 2005-03-04 2005-09-23 Intermediate and process for preparing of beta- anomer enriched 21deoxy, 21 ,21-difluoro-d-ribofuranosyl nucleosides

Publications (1)

Publication Number Publication Date
MX2007010316A true MX2007010316A (es) 2008-02-19

Family

ID=35457749

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007010316A MX2007010316A (es) 2005-03-04 2005-09-23 Intermediario de 21-desoxi, 21,21-difluoro-d-ribofuranosil nucleosidos enriquecidos en (-anomero y proceso para prepararlo.

Country Status (24)

Country Link
US (2) US7235647B2 (es)
EP (1) EP1853616B1 (es)
JP (1) JP2008531680A (es)
KR (1) KR20070112774A (es)
CN (1) CN101203524B (es)
AP (1) AP2219A (es)
AR (1) AR052860A1 (es)
AT (1) ATE458743T1 (es)
AU (1) AU2005328519B2 (es)
BR (1) BRPI0520050A2 (es)
CA (1) CA2598895A1 (es)
CL (1) CL2005003456A1 (es)
DE (1) DE602005019626D1 (es)
EA (1) EA011558B1 (es)
ES (1) ES2341663T3 (es)
GE (1) GEP20094822B (es)
IL (1) IL184957A (es)
MX (1) MX2007010316A (es)
MY (1) MY141378A (es)
NZ (1) NZ560735A (es)
TW (1) TWI333493B (es)
UA (1) UA88940C2 (es)
WO (1) WO2006092808A1 (es)
ZA (1) ZA200706392B (es)

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KR20070112774A (ko) * 2005-03-04 2007-11-27 다브르 파마 리미티드 베타―아노머가 많은２１데옥시，２１，２１－디플루오로－ｄ－리보푸라노실뉴클레오시드의 제조를 위한 중간체 및 제조 방법
WO2008026222A2 (en) * 2006-08-28 2008-03-06 Shilpa Medicare Ltd Process and intermediates of 2,2' difluoronucleosides
KR100846143B1 (ko) 2007-02-28 2008-07-14 (주) 유일팜테크 2'-데옥시-2',2'-디플루오로시티딘의 전구체 및 그의제조방법
CN102093451A (zh) * 2009-12-12 2011-06-15 上海华理生物医药有限公司 一种制备吉西他滨中间体的方法
CN102153601A (zh) * 2011-02-26 2011-08-17 湖南欧亚生物有限公司 一种高选择性的制备盐酸吉西他滨以及其中间体的方法
CN102603838B (zh) * 2012-02-14 2015-02-18 江苏八巨药业有限公司 一种制备吉西他滨盐酸盐的方法
CN103232508A (zh) * 2012-05-22 2013-08-07 湖北一半天制药有限公司 工业化盐酸吉西他滨的合成方法
CN110088076A (zh) * 2016-12-28 2019-08-02 株式会社钟化 醇化合物的制造方法
WO2018200859A1 (en) 2017-04-26 2018-11-01 Kalman Thomas I Multitargeted nucleoside derivatives
CN107200757B (zh) * 2017-06-29 2020-06-02 上海泓博智源医药股份有限公司 一种桥环氟代酯及其制备方法和应用
CN110511258A (zh) * 2018-05-21 2019-11-29 中国科学院上海药物研究所 一种胞嘧啶核苷的制备方法
CN109796506A (zh) * 2019-01-28 2019-05-24 江苏八巨药业有限公司 一种吉西他滨关键中间体的制备方法
CN111909229B (zh) * 2020-08-12 2023-05-05 福建瑞博奥科技有限公司 一种β-烟酰胺核糖氯化物的制备方法

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US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
ZA859008B (en) * 1984-12-04 1987-07-29 Lilly Co Eli The treatment of tumors in mammals
ATE92499T1 (de) * 1984-12-04 1993-08-15 Lilly Co Eli Tumorbehandlung bei saeugetieren.
US4814438A (en) * 1986-12-24 1989-03-21 Eli Lilly And Company Immunoglobulin conjugates of 2',2'-difluronucleosides
US4994558A (en) * 1986-12-24 1991-02-19 Eli Lilly And Company Immunoglobulin conjugates
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5644043A (en) * 1988-02-16 1997-07-01 Eli Lilly And Company 2',3'-dideoxy-2',2'-difluoronucleosides and intermediates
US5401861A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5821357A (en) * 1992-06-22 1998-10-13 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
NO932286L (no) * 1992-06-22 1993-12-23 Lilly Co Eli Stereoselektiv anion-glykosyleringsprosess
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5594124A (en) * 1992-06-22 1997-01-14 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
CA2105112C (en) * 1992-09-01 2005-08-02 Thomas C. Britton A process for anomerizing nucleosides
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5521294A (en) * 1995-01-18 1996-05-28 Eli Lilly And Company 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
FR2808797A1 (fr) * 2000-05-09 2001-11-16 Hoechst Marion Roussel Inc Nouveaux derives de l'uridine, leur procede de preparation et leur application comme medicaments
EP1831236A4 (en) * 2004-12-30 2013-11-20 Hanmi Science Co Ltd PROCESS FOR PREPARING 2'-DEOXY-2 ', 2'-DIFLUOROCYTIDINE
KR20070112774A (ko) * 2005-03-04 2007-11-27 다브르 파마 리미티드 베타―아노머가 많은２１데옥시，２１，２１－디플루오로－ｄ－리보푸라노실뉴클레오시드의 제조를 위한 중간체 및 제조 방법

Also Published As

Publication number Publication date
CN101203524B (zh) 2011-06-15
KR20070112774A (ko) 2007-11-27
AU2005328519A1 (en) 2006-09-08
IL184957A0 (en) 2007-12-03
DE602005019626D1 (de) 2010-04-08
MY141378A (en) 2010-04-30
EP1853616B1 (en) 2010-02-24
IL184957A (en) 2011-06-30
CL2005003456A1 (es) 2008-05-02
EA200701889A1 (ru) 2008-02-28
ES2341663T3 (es) 2010-06-24
US20060217547A1 (en) 2006-09-28
AU2005328519B2 (en) 2012-03-01
JP2008531680A (ja) 2008-08-14
AP2219A (en) 2011-03-22
CN101203524A (zh) 2008-06-18
UA88940C2 (ru) 2009-12-10
TWI333493B (en) 2010-11-21
GEP20094822B (en) 2009-11-10
US20070208170A1 (en) 2007-09-06
US7235647B2 (en) 2007-06-26
BRPI0520050A2 (pt) 2009-11-17
ATE458743T1 (de) 2010-03-15
WO2006092808A1 (en) 2006-09-08
NZ560735A (en) 2009-07-31
EP1853616A1 (en) 2007-11-14
CA2598895A1 (en) 2006-09-08
AP2007004098A0 (en) 2007-08-31
EA011558B1 (ru) 2009-04-28
TW200643027A (en) 2006-12-16
AR052860A1 (es) 2007-04-04
ZA200706392B (en) 2008-09-25

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