WO2008026222A3 - Process and intermediates of 2,2' difluoronucleosides - Google Patents

Process and intermediates of 2,2' difluoronucleosides Download PDF

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Publication number
WO2008026222A3
WO2008026222A3 PCT/IN2007/000354 IN2007000354W WO2008026222A3 WO 2008026222 A3 WO2008026222 A3 WO 2008026222A3 IN 2007000354 W IN2007000354 W IN 2007000354W WO 2008026222 A3 WO2008026222 A3 WO 2008026222A3
Authority
WO
WIPO (PCT)
Prior art keywords
deoxy
difluoro
beta
intermediates
difluoronucleosides
Prior art date
Application number
PCT/IN2007/000354
Other languages
French (fr)
Other versions
WO2008026222A2 (en
Inventor
B Vishnukant
Prashant Purohit
K Paparao
Veereshappa Veereshappa
Original Assignee
Shilpa Medicare Ltd
B Vishnukant
Prashant Purohit
K Paparao
Veereshappa Veereshappa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shilpa Medicare Ltd, B Vishnukant, Prashant Purohit, K Paparao, Veereshappa Veereshappa filed Critical Shilpa Medicare Ltd
Publication of WO2008026222A2 publication Critical patent/WO2008026222A2/en
Publication of WO2008026222A3 publication Critical patent/WO2008026222A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen

Abstract

The present invention provides novel 1-trihaloacetimido-2-deoxy-2,2'-difluoro-3,5-di-O-protected ribose intermediates. The compounds are useful in the preparation of 2'-deoxy-2,2'-difluoro-beta nucleosides and more particularly 2'-deoxy-2,2'-difluoro-beta cytidine and other beta anomer nucleosides and its salts having antiviral and anticancer activity
PCT/IN2007/000354 2006-08-28 2007-08-20 Process and intermediates of 2,2' difluoronucleosides WO2008026222A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1536CH2006 2006-08-28
IN1536/CHE/2006 2006-08-28

Publications (2)

Publication Number Publication Date
WO2008026222A2 WO2008026222A2 (en) 2008-03-06
WO2008026222A3 true WO2008026222A3 (en) 2009-06-18

Family

ID=39136375

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000354 WO2008026222A2 (en) 2006-08-28 2007-08-20 Process and intermediates of 2,2' difluoronucleosides

Country Status (1)

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WO (1) WO2008026222A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006092808A1 (en) * 2005-03-04 2006-09-08 Dabur Pharma Limited Intermediate and process for preparing of beta- anomer enriched 21deoxy, 21 ,21-difluoro-d-ribofuranosyl nucleosides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006092808A1 (en) * 2005-03-04 2006-09-08 Dabur Pharma Limited Intermediate and process for preparing of beta- anomer enriched 21deoxy, 21 ,21-difluoro-d-ribofuranosyl nucleosides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANGEW. CHEM. INT. ED ENGL., vol. 25, no. 3, 1986, pages 212 - 235 *
NUCLEOSIDES NUCLEOTIDES, vol. 17, no. 12, 1998, pages 2199 - 2210 *

Also Published As

Publication number Publication date
WO2008026222A2 (en) 2008-03-06

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