EP1831236A4 - Method for the preparation of 2'-deoxy-2',2'-difluorocytidine - Google Patents
Method for the preparation of 2'-deoxy-2',2'-difluorocytidineInfo
- Publication number
- EP1831236A4 EP1831236A4 EP05823850.2A EP05823850A EP1831236A4 EP 1831236 A4 EP1831236 A4 EP 1831236A4 EP 05823850 A EP05823850 A EP 05823850A EP 1831236 A4 EP1831236 A4 EP 1831236A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- formula
- difluorocytidine
- deoxy
- preparation
- nucleoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20040116316 | 2004-12-30 | ||
PCT/KR2005/001954 WO2006070985A1 (en) | 2004-12-30 | 2005-06-23 | METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE |
PCT/KR2005/004633 WO2006071090A1 (en) | 2004-12-30 | 2005-12-29 | Method for the preparation of 2'-deoxy-2',2'-difluorocytidine |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1831236A1 EP1831236A1 (en) | 2007-09-12 |
EP1831236A4 true EP1831236A4 (en) | 2013-11-20 |
Family
ID=36615168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05823850.2A Withdrawn EP1831236A4 (en) | 2004-12-30 | 2005-12-29 | Method for the preparation of 2'-deoxy-2',2'-difluorocytidine |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1831236A4 (en) |
CN (1) | CN101010329B (en) |
AU (1) | AU2005320374B2 (en) |
BR (1) | BRPI0514718A (en) |
NO (1) | NO20070865L (en) |
WO (1) | WO2006071090A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20070112774A (en) * | 2005-03-04 | 2007-11-27 | 다브르 파마 리미티드 | Intermediate and process for preparing of beta-anomer enriched 21deoxy,21,21-difluoro-d-ribofuranosyl nucleosides |
CN100475832C (en) | 2007-05-31 | 2009-04-08 | 南京卡文迪许生物工程技术有限公司 | Novel highly-solid selectively synthesizing gemcitabine process and intermediate |
CN101381387B (en) * | 2007-09-06 | 2011-08-31 | 上海希迪制药有限公司 | Method for preparing 2'-deoxy-2',2'-difluoro-beta-cytidine hydrochlorate |
CN101883570B (en) * | 2007-11-06 | 2013-06-19 | 药华医药股份有限公司 | Synthesis of beta-nucleosides |
CA2727813A1 (en) * | 2008-06-12 | 2009-12-17 | Scinopharm Taiwan, Ltd. | Crystalline polymorphs of gemcitabine base |
WO2010029574A2 (en) * | 2008-08-18 | 2010-03-18 | Vishwanath Kannan | An improved process for the preparation of gemcitabine and its intermediates using novel protecting groups and ion exchange resins |
CN102617483B (en) * | 2011-06-30 | 2013-04-24 | 江苏豪森药业股份有限公司 | Process for recycling cytosine during preparing process of gemcitabine hydrochloride |
CN102617484B (en) * | 2011-06-30 | 2014-05-14 | 江苏豪森药业股份有限公司 | Process for recycling cytosine during preparing process of gemcitabine hydrochloride |
CN102432654A (en) * | 2011-09-26 | 2012-05-02 | 宋云龙 | Gemcitabine amide derivates, and preparation method and application thereof |
CN103224541B (en) * | 2013-04-27 | 2015-07-01 | 江苏豪森药业股份有限公司 | Gemcitabine alpha-isomer conversion recovery process |
CN106317147B (en) * | 2015-07-06 | 2018-11-27 | 扬州硒瑞恩生物医药科技有限公司 | nucleoside compound and preparation method thereof |
CN109305992A (en) * | 2017-07-28 | 2019-02-05 | 江苏先声药业有限公司 | A kind of preparation method of azacitidine |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1442420A (en) * | 2003-04-08 | 2003-09-17 | 深圳市汉德森技术有限公司 | Method of preparing 2'-deoxy-2',2'-difluoro-beta-nucleoside or its medical salt using 1,6-dehydro-beta-D-glucose as raw material |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223608A (en) * | 1987-08-28 | 1993-06-29 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
US5606048A (en) * | 1992-06-22 | 1997-02-25 | Eli Lilly And Company | Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
FI932871A (en) * | 1992-06-22 | 1993-12-23 | Lilly Co Eli | STEREOSELECTIVE ANJONGLYKOSYLATIONSPROCESS |
US5401861A (en) * | 1992-06-22 | 1995-03-28 | Eli Lilly And Company | Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates |
US5371210A (en) * | 1992-06-22 | 1994-12-06 | Eli Lilly And Company | Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
-
2005
- 2005-12-29 AU AU2005320374A patent/AU2005320374B2/en not_active Ceased
- 2005-12-29 BR BRPI0514718-2A patent/BRPI0514718A/en not_active IP Right Cessation
- 2005-12-29 WO PCT/KR2005/004633 patent/WO2006071090A1/en active Application Filing
- 2005-12-29 CN CN200580029086XA patent/CN101010329B/en not_active Expired - Fee Related
- 2005-12-29 EP EP05823850.2A patent/EP1831236A4/en not_active Withdrawn
-
2007
- 2007-02-15 NO NO20070865A patent/NO20070865L/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1442420A (en) * | 2003-04-08 | 2003-09-17 | 深圳市汉德森技术有限公司 | Method of preparing 2'-deoxy-2',2'-difluoro-beta-nucleoside or its medical salt using 1,6-dehydro-beta-D-glucose as raw material |
Non-Patent Citations (4)
Title |
---|
BARDOS, THOMAS J. ET AL: "Stereoselective synthesis of the anomeric 5-mercapto-2'-deoxyuridines and of some other anomeric 2-deoxy-D-erythropentonucleosides", TETRAHEDRON LETTERS, vol. 16, 1966, pages 1759 - 1764, XP002713325, ISSN: 0040-4039 * |
KOTICK, MICHAEL P. ET AL: "Synthesis of 5-s-substituted 2'-deoxyuridines. Study of the factors influencing the stereoselectivity of the silyl modification of the Hilbert-Johnson reaction", JOURNAL OF ORGANIC CHEMISTRY, vol. 34, no. 12, 1969, pages 3806 - 3813, XP002713326, ISSN: 0022-3263 * |
See also references of WO2006071090A1 * |
VORBRUEGGEN, HELMUT ET AL: "Synthesis of nucleosides", ORGANIC REACTIONS, 2000, (HOBOKEN, NJ, UNITED STATES), XP002713324 * |
Also Published As
Publication number | Publication date |
---|---|
EP1831236A1 (en) | 2007-09-12 |
NO20070865L (en) | 2007-04-24 |
BRPI0514718A (en) | 2008-07-01 |
AU2005320374B2 (en) | 2009-01-08 |
AU2005320374A1 (en) | 2006-07-06 |
CN101010329A (en) | 2007-08-01 |
CN101010329B (en) | 2011-06-08 |
WO2006071090A1 (en) | 2006-07-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20070302 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: KIM, HAN KYONG Inventor name: CHOI, CHANG-JU Inventor name: CHANG, YOUNG-KIL Inventor name: LEE, HOE CHUL Inventor name: LEE, JAEHEON Inventor name: PARK, GHA SEUNG Inventor name: KIM, CHEOL KYONG Inventor name: LEE, JAE CHUL Inventor name: BANG, HYO-JEONG Inventor name: LEE, MOONSUB Inventor name: LEE, GWAN SUN |
|
DAX | Request for extension of the european patent (deleted) | ||
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: HANMI HOLDINGS CO., LTD. |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: HANMI SCIENCE CO., LTD. |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07H 19/04 20060101AFI20130923BHEP |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07H 19/04 20060101AFI20131009BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20131021 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20140520 |