EP1831236A4 - Methode servant a preparer 2'-deoxy-2',2'-difluorocytidine - Google Patents

Methode servant a preparer 2'-deoxy-2',2'-difluorocytidine

Info

Publication number
EP1831236A4
EP1831236A4 EP05823850.2A EP05823850A EP1831236A4 EP 1831236 A4 EP1831236 A4 EP 1831236A4 EP 05823850 A EP05823850 A EP 05823850A EP 1831236 A4 EP1831236 A4 EP 1831236A4
Authority
EP
European Patent Office
Prior art keywords
formula
difluorocytidine
deoxy
preparation
nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05823850.2A
Other languages
German (de)
English (en)
Other versions
EP1831236A1 (fr
Inventor
Jaeheon Lee
Gha Seung Park
Moonsub Lee
Hyo-Jeong Bang
Jae Chul Lee
Cheol Kyong Kim
Chang-Ju Choi
Han Kyong Kim
Hoe Chul Lee
Young-Kil Chang
Gwan Sun Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanmi Science Co Ltd
Original Assignee
Hanmi Science Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/KR2005/001954 external-priority patent/WO2006070985A1/fr
Application filed by Hanmi Science Co Ltd filed Critical Hanmi Science Co Ltd
Publication of EP1831236A1 publication Critical patent/EP1831236A1/fr
Publication of EP1831236A4 publication Critical patent/EP1831236A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
EP05823850.2A 2004-12-30 2005-12-29 Methode servant a preparer 2'-deoxy-2',2'-difluorocytidine Withdrawn EP1831236A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20040116316 2004-12-30
PCT/KR2005/001954 WO2006070985A1 (fr) 2004-12-30 2005-06-23 Méthode de synthèse de la 2’-désoxy-2’,2’-difluorocytidine
PCT/KR2005/004633 WO2006071090A1 (fr) 2004-12-30 2005-12-29 Methode servant a preparer 2'-deoxy-2',2'-difluorocytidine

Publications (2)

Publication Number Publication Date
EP1831236A1 EP1831236A1 (fr) 2007-09-12
EP1831236A4 true EP1831236A4 (fr) 2013-11-20

Family

ID=36615168

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05823850.2A Withdrawn EP1831236A4 (fr) 2004-12-30 2005-12-29 Methode servant a preparer 2'-deoxy-2',2'-difluorocytidine

Country Status (6)

Country Link
EP (1) EP1831236A4 (fr)
CN (1) CN101010329B (fr)
AU (1) AU2005320374B2 (fr)
BR (1) BRPI0514718A (fr)
NO (1) NO20070865L (fr)
WO (1) WO2006071090A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005019626D1 (de) * 2005-03-04 2010-04-08 Fresenius Kabi Oncology Ltd Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'-difluor-d-ribufuranosylnukleosiden
CN100475832C (zh) 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
CN101381387B (zh) * 2007-09-06 2011-08-31 上海希迪制药有限公司 制备2'-脱氧-2',2'-二氟-β-胞苷盐酸盐的方法
KR20100102107A (ko) * 2007-11-06 2010-09-20 파마이센시아 코퍼레이션 β-뉴클레오시드의 새로운 합성 방법
CA2727813A1 (fr) * 2008-06-12 2009-12-17 Scinopharm Taiwan, Ltd. Polymorphes cristallins de la base gemcitabine
WO2010029574A2 (fr) * 2008-08-18 2010-03-18 Vishwanath Kannan Procédé amélioré de préparation de gemcitabine et de ses intermédiaires au moyen de nouveaux groupes de protection et de résines échangeuses d'ions
CN102617484B (zh) * 2011-06-30 2014-05-14 江苏豪森药业股份有限公司 盐酸吉西他滨制备过程中胞嘧啶的回收处理方法
CN102617483B (zh) * 2011-06-30 2013-04-24 江苏豪森药业股份有限公司 盐酸吉西他滨制备过程中胞嘧啶的回收处理方法
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
CN103224541B (zh) * 2013-04-27 2015-07-01 江苏豪森药业股份有限公司 吉西他滨α-异构体转化回收工艺
CN106317147B (zh) * 2015-07-06 2018-11-27 扬州硒瑞恩生物医药科技有限公司 核苷类化合物及其制备方法
CN109305992A (zh) * 2017-07-28 2019-02-05 江苏先声药业有限公司 一种阿扎胞苷的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1442420A (zh) * 2003-04-08 2003-09-17 深圳市汉德森技术有限公司 以1，6－脱水－β－D－葡萄糖为原料制备2'－脱氧－2'，2'－二氟－β－核胞苷或其药用盐的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
CA2098874C (fr) * 1992-06-22 2004-04-20 Ta-Sen Chou Methode de glycosylation anionique stereoselective
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5401861A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1442420A (zh) * 2003-04-08 2003-09-17 深圳市汉德森技术有限公司 以1，6－脱水－β－D－葡萄糖为原料制备2'－脱氧－2'，2'－二氟－β－核胞苷或其药用盐的方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BARDOS, THOMAS J. ET AL: "Stereoselective synthesis of the anomeric 5-mercapto-2'-deoxyuridines and of some other anomeric 2-deoxy-D-erythropentonucleosides", TETRAHEDRON LETTERS, vol. 16, 1966, pages 1759 - 1764, XP002713325, ISSN: 0040-4039 *
KOTICK, MICHAEL P. ET AL: "Synthesis of 5-s-substituted 2'-deoxyuridines. Study of the factors influencing the stereoselectivity of the silyl modification of the Hilbert-Johnson reaction", JOURNAL OF ORGANIC CHEMISTRY, vol. 34, no. 12, 1969, pages 3806 - 3813, XP002713326, ISSN: 0022-3263 *
See also references of WO2006071090A1 *
VORBRUEGGEN, HELMUT ET AL: "Synthesis of nucleosides", ORGANIC REACTIONS, 2000, (HOBOKEN, NJ, UNITED STATES), XP002713324 *

Also Published As

Publication number Publication date
AU2005320374A1 (en) 2006-07-06
NO20070865L (no) 2007-04-24
CN101010329A (zh) 2007-08-01
EP1831236A1 (fr) 2007-09-12
AU2005320374B2 (en) 2009-01-08
CN101010329B (zh) 2011-06-08
BRPI0514718A (pt) 2008-07-01
WO2006071090A1 (fr) 2006-07-06

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: KIM, HAN KYONG

Inventor name: CHOI, CHANG-JU

Inventor name: CHANG, YOUNG-KIL

Inventor name: LEE, HOE CHUL

Inventor name: LEE, JAEHEON

Inventor name: PARK, GHA SEUNG

Inventor name: KIM, CHEOL KYONG

Inventor name: LEE, JAE CHUL

Inventor name: BANG, HYO-JEONG

Inventor name: LEE, MOONSUB

Inventor name: LEE, GWAN SUN

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: HANMI HOLDINGS CO., LTD.

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: HANMI SCIENCE CO., LTD.

RIC1 Information provided on ipc code assigned before grant

Ipc: C07H 19/04 20060101AFI20130923BHEP

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Ipc: C07H 19/04 20060101AFI20131009BHEP

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