AU2005320374B2 - Method for the preparation of 2'-deoxy-2',2'-difluorocytidine - Google Patents

Method for the preparation of 2'-deoxy-2',2'-difluorocytidine Download PDF

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Publication number
AU2005320374B2
AU2005320374B2 AU2005320374A AU2005320374A AU2005320374B2 AU 2005320374 B2 AU2005320374 B2 AU 2005320374B2 AU 2005320374 A AU2005320374 A AU 2005320374A AU 2005320374 A AU2005320374 A AU 2005320374A AU 2005320374 B2 AU2005320374 B2 AU 2005320374B2
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AU
Australia
Prior art keywords
mixture
formula
deoxy
nucleoside
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005320374A
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English (en)
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AU2005320374A1 (en
Inventor
Hyo-Jeong Bang
Young-Kil Chang
Chang-Ju Choi
Cheol Kyong Kim
Han Kyong Kim
Gwan Sun Lee
Hoe Chul Lee
Jae Chul Lee
Jaeheon Lee
Moonsub Lee
Gha Seung Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanmi Science Co Ltd
Original Assignee
Hanmi Science Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/KR2005/001954 external-priority patent/WO2006070985A1/fr
Application filed by Hanmi Science Co Ltd filed Critical Hanmi Science Co Ltd
Publication of AU2005320374A1 publication Critical patent/AU2005320374A1/en
Application granted granted Critical
Publication of AU2005320374B2 publication Critical patent/AU2005320374B2/en
Assigned to HANMI HOLDINGS CO., LTD. reassignment HANMI HOLDINGS CO., LTD. Request for Assignment Assignors: HANMI PHARM. CO., LTD.
Assigned to HANMI SCIENCE CO., LTD. reassignment HANMI SCIENCE CO., LTD. Request to Amend Deed and Register Assignors: HANMI HOLDINGS CO., LTD.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
AU2005320374A 2004-12-30 2005-12-29 Method for the preparation of 2'-deoxy-2',2'-difluorocytidine Ceased AU2005320374B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR10-2004-0116316 2004-12-30
KR20040116316 2004-12-30
AUPCT/KR2005/001954 2005-06-23
PCT/KR2005/001954 WO2006070985A1 (fr) 2004-12-30 2005-06-23 Méthode de synthèse de la 2’-désoxy-2’,2’-difluorocytidine
PCT/KR2005/004633 WO2006071090A1 (fr) 2004-12-30 2005-12-29 Methode servant a preparer 2'-deoxy-2',2'-difluorocytidine

Publications (2)

Publication Number Publication Date
AU2005320374A1 AU2005320374A1 (en) 2006-07-06
AU2005320374B2 true AU2005320374B2 (en) 2009-01-08

Family

ID=36615168

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005320374A Ceased AU2005320374B2 (en) 2004-12-30 2005-12-29 Method for the preparation of 2'-deoxy-2',2'-difluorocytidine

Country Status (6)

Country Link
EP (1) EP1831236A4 (fr)
CN (1) CN101010329B (fr)
AU (1) AU2005320374B2 (fr)
BR (1) BRPI0514718A (fr)
NO (1) NO20070865L (fr)
WO (1) WO2006071090A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0520050A2 (pt) * 2005-03-04 2009-11-17 Dabur Pharma Ltd composto, processo para a preparação de um composto e processo de glicosilação estereoseletiva para a preparação de mais de 99% de anÈmero b enriquecido de hidrocloreto de gencitabina
CN100475832C (zh) 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
CN101381387B (zh) * 2007-09-06 2011-08-31 上海希迪制药有限公司 制备2'-脱氧-2',2'-二氟-β-胞苷盐酸盐的方法
AU2008323923A1 (en) * 2007-11-06 2009-05-14 Pharmaessentia Corporation Novel synthesis of beta-nucleosides
CN102216314A (zh) * 2008-06-12 2011-10-12 台湾神隆股份有限公司 吉西他滨碱的结晶多晶型物
WO2010029574A2 (fr) * 2008-08-18 2010-03-18 Vishwanath Kannan Procédé amélioré de préparation de gemcitabine et de ses intermédiaires au moyen de nouveaux groupes de protection et de résines échangeuses d'ions
CN102617484B (zh) * 2011-06-30 2014-05-14 江苏豪森药业股份有限公司 盐酸吉西他滨制备过程中胞嘧啶的回收处理方法
CN102617483B (zh) * 2011-06-30 2013-04-24 江苏豪森药业股份有限公司 盐酸吉西他滨制备过程中胞嘧啶的回收处理方法
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
CN103224541B (zh) * 2013-04-27 2015-07-01 江苏豪森药业股份有限公司 吉西他滨α-异构体转化回收工艺
CN106317147B (zh) * 2015-07-06 2018-11-27 扬州硒瑞恩生物医药科技有限公司 核苷类化合物及其制备方法
CN109305992A (zh) * 2017-07-28 2019-02-05 江苏先声药业有限公司 一种阿扎胞苷的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5744597A (en) * 1992-06-22 1998-04-28 Eli Lilly And Company Stereoselective anion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5945547A (en) * 1987-08-28 1999-08-31 Eli Lilly And Company Imtermediate in process to make 2', 2'-difluoronucleosides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5401861A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
CN1228342C (zh) * 2003-04-08 2005-11-23 深圳市汉德森技术有限公司 以1，6－脱水－β－D－葡萄糖为原料制备2'－脱氧－2'，2'－二氟－β－核胞苷或其药用盐的方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945547A (en) * 1987-08-28 1999-08-31 Eli Lilly And Company Imtermediate in process to make 2', 2'-difluoronucleosides
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5744597A (en) * 1992-06-22 1998-04-28 Eli Lilly And Company Stereoselective anion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Also Published As

Publication number Publication date
NO20070865L (no) 2007-04-24
AU2005320374A1 (en) 2006-07-06
EP1831236A4 (fr) 2013-11-20
WO2006071090A1 (fr) 2006-07-06
CN101010329A (zh) 2007-08-01
CN101010329B (zh) 2011-06-08
EP1831236A1 (fr) 2007-09-12
BRPI0514718A (pt) 2008-07-01

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: HANMI HOLDINGS CO., LTD.

Free format text: FORMER OWNER WAS: HANMI PHARM. CO., LTD.

DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE PATENTEE TO READ HANMI SCIENCE CO., LTD. .

MK14 Patent ceased section 143(a) (annual fees not paid) or expired