BRPI0514718A - método para a preparação de 2'-desoxi-2', 2'-diflúor-citidina - Google Patents

método para a preparação de 2'-desoxi-2', 2'-diflúor-citidina

Info

Publication number
BRPI0514718A
BRPI0514718A BRPI0514718-2A BRPI0514718A BRPI0514718A BR PI0514718 A BRPI0514718 A BR PI0514718A BR PI0514718 A BRPI0514718 A BR PI0514718A BR PI0514718 A BRPI0514718 A BR PI0514718A
Authority
BR
Brazil
Prior art keywords
formula
deoxy
cytidine
difluoro
preparation
Prior art date
Application number
BRPI0514718-2A
Other languages
English (en)
Inventor
Jaeheon Lee
Gha Seung Park
Moonsub Lee
Hyo-Jeong Bang
Jae Chul Lee
Cheol Kyong Kim
Chang-Ju Choi
Han Kyong Kim
Hoe Chul Lee
Young-Kil Chang
Gwan-Sun Lee
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/KR2005/001954 external-priority patent/WO2006070985A1/en
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of BRPI0514718A publication Critical patent/BRPI0514718A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

MéTODO PARA A PREPARAçãO DE 2'-DESOXI-2',2'-DIFLúOR-CITIDINA Esta invenção refere-se a um método aperfeiçoado para preparar de forma estereosseletiva a 2'-desoxi-2', 2'-diflúor-citidina da fórmula (I), compreendendo as etapas de reagir um composto de 1-halo-riboturanose da fórmula (III) com um nucleobase da fórmula (IV) em um solvente, para obter um nucleosídeo da fórmula (II), e ao mesmo tempo, removendo o halogeneto de silila da fórmula (V) produzido durante a reação; e desproteger o nucleosídeo da fórmula (II), para obter a 2'-desoxi-2',2'-diflúor-citidina da fórmula (I).
BRPI0514718-2A 2004-12-30 2005-12-29 método para a preparação de 2'-desoxi-2', 2'-diflúor-citidina BRPI0514718A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20040116316 2004-12-30
PCT/KR2005/001954 WO2006070985A1 (en) 2004-12-30 2005-06-23 METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
PCT/KR2005/004633 WO2006071090A1 (en) 2004-12-30 2005-12-29 Method for the preparation of 2'-deoxy-2',2'-difluorocytidine

Publications (1)

Publication Number Publication Date
BRPI0514718A true BRPI0514718A (pt) 2008-07-01

Family

ID=36615168

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514718-2A BRPI0514718A (pt) 2004-12-30 2005-12-29 método para a preparação de 2'-desoxi-2', 2'-diflúor-citidina

Country Status (6)

Country Link
EP (1) EP1831236A4 (pt)
CN (1) CN101010329B (pt)
AU (1) AU2005320374B2 (pt)
BR (1) BRPI0514718A (pt)
NO (1) NO20070865L (pt)
WO (1) WO2006071090A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005019626D1 (de) * 2005-03-04 2010-04-08 Fresenius Kabi Oncology Ltd Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'-difluor-d-ribufuranosylnukleosiden
CN100475832C (zh) 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
CN101381387B (zh) * 2007-09-06 2011-08-31 上海希迪制药有限公司 制备2'-脱氧-2',2'-二氟-β-胞苷盐酸盐的方法
KR20100102107A (ko) * 2007-11-06 2010-09-20 파마이센시아 코퍼레이션 β-뉴클레오시드의 새로운 합성 방법
CA2727813A1 (en) * 2008-06-12 2009-12-17 Scinopharm Taiwan, Ltd. Crystalline polymorphs of gemcitabine base
WO2010029574A2 (en) * 2008-08-18 2010-03-18 Vishwanath Kannan An improved process for the preparation of gemcitabine and its intermediates using novel protecting groups and ion exchange resins
CN102617484B (zh) * 2011-06-30 2014-05-14 江苏豪森药业股份有限公司 盐酸吉西他滨制备过程中胞嘧啶的回收处理方法
CN102617483B (zh) * 2011-06-30 2013-04-24 江苏豪森药业股份有限公司 盐酸吉西他滨制备过程中胞嘧啶的回收处理方法
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
CN103224541B (zh) * 2013-04-27 2015-07-01 江苏豪森药业股份有限公司 吉西他滨α-异构体转化回收工艺
CN106317147B (zh) * 2015-07-06 2018-11-27 扬州硒瑞恩生物医药科技有限公司 核苷类化合物及其制备方法
CN109305992A (zh) * 2017-07-28 2019-02-05 江苏先声药业有限公司 一种阿扎胞苷的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
CA2098874C (en) * 1992-06-22 2004-04-20 Ta-Sen Chou Stereoselective anion glycosylation process
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5401861A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
CN1228342C (zh) * 2003-04-08 2005-11-23 深圳市汉德森技术有限公司 以1，6－脱水－β－D－葡萄糖为原料制备2'－脱氧－2'，2'－二氟－β－核胞苷或其药用盐的方法

Also Published As

Publication number Publication date
AU2005320374A1 (en) 2006-07-06
NO20070865L (no) 2007-04-24
EP1831236A4 (en) 2013-11-20
CN101010329A (zh) 2007-08-01
EP1831236A1 (en) 2007-09-12
AU2005320374B2 (en) 2009-01-08
CN101010329B (zh) 2011-06-08
WO2006071090A1 (en) 2006-07-06

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: HANMI HOLDINGS CO., LTD. (KR)

Free format text: TRANSFERIDO DE: HANMI PHARM. CO., LTD.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.