ATE548366T1 - Verfahren zur herstellung von dioxolan nukleosidanalogavorstufen - Google Patents
Verfahren zur herstellung von dioxolan nukleosidanalogavorstufenInfo
- Publication number
- ATE548366T1 ATE548366T1 AT03731646T AT03731646T ATE548366T1 AT E548366 T1 ATE548366 T1 AT E548366T1 AT 03731646 T AT03731646 T AT 03731646T AT 03731646 T AT03731646 T AT 03731646T AT E548366 T1 ATE548366 T1 AT E548366T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- producing
- dioxolane
- analogo
- precursors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35096802P | 2002-01-25 | 2002-01-25 | |
| PCT/CA2003/000085 WO2003062229A1 (en) | 2002-01-25 | 2003-01-23 | Process for producing dioxolane nucleoside analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE548366T1 true ATE548366T1 (de) | 2012-03-15 |
Family
ID=27613448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03731646T ATE548366T1 (de) | 2002-01-25 | 2003-01-23 | Verfahren zur herstellung von dioxolan nukleosidanalogavorstufen |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20050085638A1 (de) |
| EP (1) | EP1467990B1 (de) |
| JP (1) | JP4441265B2 (de) |
| AT (1) | ATE548366T1 (de) |
| AU (1) | AU2003236757B2 (de) |
| CA (1) | CA2473736C (de) |
| WO (1) | WO2003062229A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60328386D1 (de) * | 2002-05-31 | 2009-08-27 | Vidacare Corp | Vorrichtung und verfahren zum erreichen von knochenmark |
| ES2568467T3 (es) | 2004-02-03 | 2016-04-29 | Emory University | Métodos para la fabricación de nucleósidos de 1,3-dioxolano |
| BRPI0813036A2 (pt) * | 2007-07-30 | 2017-10-24 | Rfs Pharma Llc | processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina. |
| CN105503838B (zh) | 2015-08-26 | 2017-05-31 | 广西慧宝源医药科技有限公司 | 曲沙他滨的合成及其晶型 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6350753B1 (en) * | 1988-04-11 | 2002-02-26 | Biochem Pharma Inc. | 2-Substituted-4-substituted-1,3-dioxolanes and use thereof |
| US5276151A (en) | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| ZA923640B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| GB9525606D0 (en) * | 1995-12-14 | 1996-02-14 | Iaf Biochem Int | Method and compositions for the synthesis of dioxolane nucleosides with - configuration |
| CA2505552C (en) * | 2002-11-18 | 2012-06-05 | Shire Biochem Inc. | Stereoselective process for the production of dioxolane nucleoside analogues |
| ES2568467T3 (es) * | 2004-02-03 | 2016-04-29 | Emory University | Métodos para la fabricación de nucleósidos de 1,3-dioxolano |
-
2003
- 2003-01-23 EP EP03731646A patent/EP1467990B1/de not_active Expired - Lifetime
- 2003-01-23 WO PCT/CA2003/000085 patent/WO2003062229A1/en active Application Filing
- 2003-01-23 US US10/502,440 patent/US20050085638A1/en not_active Abandoned
- 2003-01-23 AT AT03731646T patent/ATE548366T1/de active
- 2003-01-23 JP JP2003562107A patent/JP4441265B2/ja not_active Expired - Lifetime
- 2003-01-23 CA CA2473736A patent/CA2473736C/en not_active Expired - Lifetime
- 2003-01-23 AU AU2003236757A patent/AU2003236757B2/en not_active Expired
-
2007
- 2007-03-05 US US11/713,724 patent/US7442813B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1467990A1 (de) | 2004-10-20 |
| CA2473736C (en) | 2011-10-11 |
| US7442813B2 (en) | 2008-10-28 |
| JP4441265B2 (ja) | 2010-03-31 |
| US20050085638A1 (en) | 2005-04-21 |
| CA2473736A1 (en) | 2003-07-31 |
| EP1467990B1 (de) | 2012-03-07 |
| WO2003062229A1 (en) | 2003-07-31 |
| US20070197784A1 (en) | 2007-08-23 |
| JP2005521660A (ja) | 2005-07-21 |
| AU2003236757B2 (en) | 2009-12-03 |
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