AP2219A - Intermediate and process for preparing of beta-anomer enriched 2'deoxy, 2',2'-difluoro-D-ribofuranosyl nucleosides. - Google Patents

Intermediate and process for preparing of beta-anomer enriched 2'deoxy, 2',2'-difluoro-D-ribofuranosyl nucleosides.

Info

Publication number
AP2219A
AP2219A AP2007004098A AP2007004098A AP2219A AP 2219 A AP2219 A AP 2219A AP 2007004098 A AP2007004098 A AP 2007004098A AP 2007004098 A AP2007004098 A AP 2007004098A AP 2219 A AP2219 A AP 2219A
Authority
AP
ARIPO
Prior art keywords
deoxy
difluoro
beta
preparing
anomer enriched
Prior art date
Application number
AP2007004098A
Other languages
English (en)
Other versions
AP2007004098A0 (en
Inventor
Golak Chandra Maikap
Deependra Bhatt
Bijan Kumar Panda
Original Assignee
Fresenius Kabi Oncology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35457749&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2219(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fresenius Kabi Oncology Ltd filed Critical Fresenius Kabi Oncology Ltd
Publication of AP2007004098A0 publication Critical patent/AP2007004098A0/xx
Application granted granted Critical
Publication of AP2219A publication Critical patent/AP2219A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AP2007004098A 2005-03-04 2005-09-23 Intermediate and process for preparing of beta-anomer enriched 2'deoxy, 2',2'-difluoro-D-ribofuranosyl nucleosides. AP2219A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN472DE2005 2005-03-04
PCT/IN2005/000322 WO2006092808A1 (en) 2005-03-04 2005-09-23 Intermediate and process for preparing of beta- anomer enriched 21deoxy, 21 ,21-difluoro-d-ribofuranosyl nucleosides

Publications (2)

Publication Number Publication Date
AP2007004098A0 AP2007004098A0 (en) 2007-08-31
AP2219A true AP2219A (en) 2011-03-22

Family

ID=35457749

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2007004098A AP2219A (en) 2005-03-04 2005-09-23 Intermediate and process for preparing of beta-anomer enriched 2'deoxy, 2',2'-difluoro-D-ribofuranosyl nucleosides.

Country Status (24)

Country Link
US (2) US7235647B2 (es)
EP (1) EP1853616B1 (es)
JP (1) JP2008531680A (es)
KR (1) KR20070112774A (es)
CN (1) CN101203524B (es)
AP (1) AP2219A (es)
AR (1) AR052860A1 (es)
AT (1) ATE458743T1 (es)
AU (1) AU2005328519B2 (es)
BR (1) BRPI0520050A2 (es)
CA (1) CA2598895A1 (es)
CL (1) CL2005003456A1 (es)
DE (1) DE602005019626D1 (es)
EA (1) EA011558B1 (es)
ES (1) ES2341663T3 (es)
GE (1) GEP20094822B (es)
IL (1) IL184957A (es)
MX (1) MX2007010316A (es)
MY (1) MY141378A (es)
NZ (1) NZ560735A (es)
TW (1) TWI333493B (es)
UA (1) UA88940C2 (es)
WO (1) WO2006092808A1 (es)
ZA (1) ZA200706392B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101203524B (zh) * 2005-03-04 2011-06-15 费森尤斯卡比肿瘤学有限公司 用于制备β-异头物富集的21-脱氧，21，21-二氟-D-呋喃核糖核苷的中间体和方法
WO2008026222A2 (en) * 2006-08-28 2008-03-06 Shilpa Medicare Ltd Process and intermediates of 2,2' difluoronucleosides
KR100846143B1 (ko) 2007-02-28 2008-07-14 (주) 유일팜테크 2'-데옥시-2',2'-디플루오로시티딘의 전구체 및 그의제조방법
CN102093451A (zh) * 2009-12-12 2011-06-15 上海华理生物医药有限公司 一种制备吉西他滨中间体的方法
CN102153601A (zh) * 2011-02-26 2011-08-17 湖南欧亚生物有限公司 一种高选择性的制备盐酸吉西他滨以及其中间体的方法
CN102603838B (zh) * 2012-02-14 2015-02-18 江苏八巨药业有限公司 一种制备吉西他滨盐酸盐的方法
CN103232508A (zh) * 2012-05-22 2013-08-07 湖北一半天制药有限公司 工业化盐酸吉西他滨的合成方法
JP7111625B2 (ja) * 2016-12-28 2022-08-02 株式会社カネカ アルコール化合物の製造法
EP3618837A4 (en) 2017-04-26 2020-11-04 Thomas I. Kalman MULTI-DIRECTIONAL NUCLEOSIDE DERIVATIVES
CN107200757B (zh) * 2017-06-29 2020-06-02 上海泓博智源医药股份有限公司 一种桥环氟代酯及其制备方法和应用
CN110511258A (zh) * 2018-05-21 2019-11-29 中国科学院上海药物研究所 一种胞嘧啶核苷的制备方法
CN109796506A (zh) * 2019-01-28 2019-05-24 江苏八巨药业有限公司 一种吉西他滨关键中间体的制备方法
CN111909229B (zh) * 2020-08-12 2023-05-05 福建瑞博奥科技有限公司 一种β-烟酰胺核糖氯化物的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
EP0577303A1 (en) * 1992-06-22 1994-01-05 Eli Lilly And Company Stereoselective glycosylation process
US5401861A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
EP0184365B1 (en) * 1984-12-04 1993-08-04 Eli Lilly And Company Improvements in the treatment of tumors in mammals
ZA859008B (en) * 1984-12-04 1987-07-29 Lilly Co Eli The treatment of tumors in mammals
US4814438A (en) * 1986-12-24 1989-03-21 Eli Lilly And Company Immunoglobulin conjugates of 2',2'-difluronucleosides
US4994558A (en) * 1986-12-24 1991-02-19 Eli Lilly And Company Immunoglobulin conjugates
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5644043A (en) * 1988-02-16 1997-07-01 Eli Lilly And Company 2',3'-dideoxy-2',2'-difluoronucleosides and intermediates
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
US5821357A (en) * 1992-06-22 1998-10-13 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
CZ123493A3 (en) * 1992-06-22 1994-02-16 Lilly Co Eli Stereoselective anionic glycosylation process
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5594124A (en) * 1992-06-22 1997-01-14 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
KR100252451B1 (ko) * 1992-09-01 2000-04-15 피터 지. 스트링거 뉴클레오사이드의아노머화방법
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5521294A (en) * 1995-01-18 1996-05-28 Eli Lilly And Company 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
FR2808797A1 (fr) * 2000-05-09 2001-11-16 Hoechst Marion Roussel Inc Nouveaux derives de l'uridine, leur procede de preparation et leur application comme medicaments
BRPI0514718A (pt) * 2004-12-30 2008-07-01 Hanmi Pharm Ind Co Ltd método para a preparação de 2'-desoxi-2', 2'-diflúor-citidina
CN101203524B (zh) * 2005-03-04 2011-06-15 费森尤斯卡比肿瘤学有限公司 用于制备β-异头物富集的21-脱氧，21，21-二氟-D-呋喃核糖核苷的中间体和方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
EP0577303A1 (en) * 1992-06-22 1994-01-05 Eli Lilly And Company Stereoselective glycosylation process
US5401861A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Also Published As

Publication number Publication date
ES2341663T3 (es) 2010-06-24
EP1853616B1 (en) 2010-02-24
MY141378A (en) 2010-04-30
CN101203524B (zh) 2011-06-15
AP2007004098A0 (en) 2007-08-31
CA2598895A1 (en) 2006-09-08
US20060217547A1 (en) 2006-09-28
IL184957A (en) 2011-06-30
ZA200706392B (en) 2008-09-25
EA200701889A1 (ru) 2008-02-28
UA88940C2 (ru) 2009-12-10
MX2007010316A (es) 2008-02-19
US20070208170A1 (en) 2007-09-06
BRPI0520050A2 (pt) 2009-11-17
KR20070112774A (ko) 2007-11-27
WO2006092808A1 (en) 2006-09-08
TWI333493B (en) 2010-11-21
EP1853616A1 (en) 2007-11-14
DE602005019626D1 (de) 2010-04-08
JP2008531680A (ja) 2008-08-14
IL184957A0 (en) 2007-12-03
AR052860A1 (es) 2007-04-04
NZ560735A (en) 2009-07-31
AU2005328519A1 (en) 2006-09-08
CN101203524A (zh) 2008-06-18
ATE458743T1 (de) 2010-03-15
EA011558B1 (ru) 2009-04-28
US7235647B2 (en) 2007-06-26
AU2005328519B2 (en) 2012-03-01
CL2005003456A1 (es) 2008-05-02
GEP20094822B (en) 2009-11-10
TW200643027A (en) 2006-12-16

Similar Documents

Publication Publication Date Title
IL184957A0 (en) Intermediate and process for preparing of beta-anomer enriched 21deoxy,21,21-difluoro-d-ribofuranosyl nucleosides
PL1928882T3 (pl) (S)-N-Metylonaltrekson, sposoby jego syntezy i jego zastosowania farmaceutyczne
HUE037069T2 (hu) Eljárás nagy tisztaságú 2,4'-metiléndifenildiizocianát elõállítására
IL189914A0 (en) Substituted 4-phenyltetrahydroisoquinolines, method of producing them, their use as medicament, and also medicament containing them
IL186523A0 (en) Substituted pyrrolo-pyridines, composition containing them, method for their producing and use thereof
IL181810A0 (en) Compositions containing uridine, and methods utilizing same
HRP20050328A2 (en) Process for the preparation of (s,s)-cis-2-benzhyd
IL165012A0 (en) (S)-4-Amino-5-chloro-2-methoxy-N-Ä1-(-tetrahydrofurylcarbonyl)-4-piperidinylmethylÜ-4-piperidinylÜbenzamide, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor
ZA200702523B (en) Process for the purification of 1,4-butanediol
IL176420A0 (en) Process for the manufacture of 2,3-dichloropyridine
ZA200709094B (en) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives as medicaments for the treatment of infertility
ZA200709090B (en) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives as medicaments for the treatment of infertility
AU2003257786A1 (en) Process for the preparation of 4, 1', 6'-trichloro-4, 1', 6'-trideoxygalactosucrose
HUP0401523A3 (en) Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them
IL181691A0 (en) Method for the preparation of 2'-deoxy-2',2'-difluorocytidine
IL186831A0 (en) 4-phenyl- 5-oxo - 1,4,5,6,7,8 - hexahydroquinoline derivatives as medicaments for the treatment of infertility
IL190596A0 (en) 9-chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments
SI2020410T1 (sl) Derivati pirido(2,3-d)pirimidina, njihova priprava, njihova terapevtska uporaba
EP1834624A4 (en) MEDICAL COMPOSITION AND MANUFACTURING METHOD THEREFOR
EP1911812A4 (en) METHOD FOR PRODUCING MELANIN, MELLANIN PRODUCED BY THE METHOD, FUNCTIONAL FILM CONTAINING MELANIN, AND PROCESS FOR PRODUCING THE FILM
IL186457A0 (en) Process for the preparation of 9,10-dehydro-12,13-desoxyepothilone derivatives
ZA200501010B (en) BenzoÄBÜchromeno-naphthyridin-7-one and pyranoÄ2'3':7,8ÜquinoÄ2,3-BÜquinoxalin-7-one compounds, process for their preparation and pharmaceutical compositions containing them.
IL187659A0 (en) Process for the preparation of n,n'-disubstituted oxabispidines
AU2003284212A8 (en) Process for the preparation of (s,s)-cis-2-phenyl-3-aminopiperidine
SI1654270T1 (sl) Postopek za pripravo 2',3'-didehidro-2',3'-dideoksinukleozidov in 2',3'-dideoksinukleozidov