YU49314B - Postupak za pripremanje 1-(2'-deoksi-2',2'-difluoro-d-ribofuranosil)-4-aminopirimidin-2-on)hidrohlorida - Google Patents

Postupak za pripremanje 1-(2'-deoksi-2',2'-difluoro-d-ribofuranosil)-4-aminopirimidin-2-on)hidrohlorida

Info

Publication number
YU49314B
YU49314B YU70895A YU70895A YU49314B YU 49314 B YU49314 B YU 49314B YU 70895 A YU70895 A YU 70895A YU 70895 A YU70895 A YU 70895A YU 49314 B YU49314 B YU 49314B
Authority
YU
Yugoslavia
Prior art keywords
aminopyrimidin
deoxy
difluoro
preparing
hydrochloride
Prior art date
Application number
YU70895A
Other languages
English (en)
Other versions
YU70895A (sh
Inventor
Richard Alan Berglund
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23397211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU49314(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of YU70895A publication Critical patent/YU70895A/sh
Publication of YU49314B publication Critical patent/YU49314B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Postupak za pripremanje gemcitabin hidrohlorida, naznačen time, što obuhvata: a) deblokiranje Гџ-1-(2'-deoksi-2', 2'-difluoro-3', 5'-di-O-benzoil-D-ribofuranosil)-4-aminopirimidin-2-ona sa katalitičkom količinom alkilamina u prisustvu metanola ili etanola u sredini koja je u osnovi bez vode; b) tretiranje rezultujućeg rastvora hlorovodoničnom kiselinom i antirastvaračem; i c) rekuperovanje rezultujućeg gemcitabin hidrohlorida u čvrstom stanju. Prijava sadrži još devet zavisnih patentnih zahteva.
YU70895A 1994-12-13 1995-11-13 Postupak za pripremanje 1-(2'-deoksi-2',2'-difluoro-d-ribofuranosil)-4-aminopirimidin-2-on)hidrohlorida YU49314B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/355,372 US5637688A (en) 1994-12-13 1994-12-13 Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

Publications (2)

Publication Number Publication Date
YU70895A YU70895A (sh) 1998-09-18
YU49314B true YU49314B (sh) 2005-06-10

Family

ID=23397211

Family Applications (1)

Application Number Title Priority Date Filing Date
YU70895A YU49314B (sh) 1994-12-13 1995-11-13 Postupak za pripremanje 1-(2'-deoksi-2',2'-difluoro-d-ribofuranosil)-4-aminopirimidin-2-on)hidrohlorida

Country Status (31)

Country Link
US (2) US5637688A (sh)
EP (1) EP0719788B1 (sh)
JP (1) JPH10510806A (sh)
KR (1) KR100424991B1 (sh)
CN (1) CN1047177C (sh)
AR (1) AR001041A1 (sh)
AT (1) ATE179986T1 (sh)
AU (1) AU689674B2 (sh)
BG (1) BG62738B1 (sh)
BR (1) BR9509979A (sh)
CO (1) CO4520286A1 (sh)
CZ (1) CZ290941B6 (sh)
DE (1) DE69509624T2 (sh)
DK (1) DK0719788T3 (sh)
ES (1) ES2130542T3 (sh)
GR (1) GR3030265T3 (sh)
HU (1) HU219021B (sh)
IL (1) IL115852A (sh)
MY (1) MY112488A (sh)
NO (1) NO306783B1 (sh)
NZ (1) NZ296476A (sh)
PE (1) PE49296A1 (sh)
PL (1) PL181732B1 (sh)
RO (1) RO117327B1 (sh)
RU (1) RU2154648C2 (sh)
SI (1) SI0719788T1 (sh)
TW (1) TW379226B (sh)
UA (1) UA48152C2 (sh)
WO (1) WO1996018637A1 (sh)
YU (1) YU49314B (sh)
ZA (1) ZA959320B (sh)

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EP0870506A1 (en) * 1997-04-11 1998-10-14 Eli Lilly And Company Compositions comprising a cryptophycin compound in combination with a synchronizing or activating agent for treating cancer
CA2315693C (en) * 1997-12-22 2010-11-30 Schering Corporation Combination of benzocycloheptapyridine compounds and antineoplastic drugs for treating proliferative diseases
US6376470B1 (en) 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
WO2002028387A1 (en) * 2000-10-03 2002-04-11 Oncopharmaceutical, Inc. Inhibitors of angiogenesis and tumor growth for local and systemic administration
WO2005014010A1 (en) * 2003-07-24 2005-02-17 Eli Lilly And Company Pharmaceutical composition comprising gemcitabine and cyclodextrines
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
EP1812457A1 (en) * 2004-07-30 2007-08-01 Pharmaessentia Corp. STEREOSELECTIVE SYNTHESIS OF ß-NUCLEOSIDES
WO2006070985A1 (en) * 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
JP2008531680A (ja) * 2005-03-04 2008-08-14 ダブール・ファーマ・リミテッド βアノマーが富化された２１−デオキシ−２１，２１−ジフルオロ−Ｄ−リボフラノシルヌクレオシドの調製のための中間体と方法
WO2006095359A1 (en) * 2005-03-10 2006-09-14 Sms Pharmaceuticals Limited Synthesis of 2-deoxy-2, 2-di fluoro-d-ribo furanose-3, 5 di(4-methy/4-nitro-chloro)benzoate and its conversion to gemcitabine hydrochloride thereof
WO2006119347A1 (en) * 2005-05-02 2006-11-09 Pharmaessentia Corp. STEREOSELECTIVE SYNTHESIS OF β-NUCLEOSIDES
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
EP1940859A1 (en) * 2005-10-28 2008-07-09 Arch Pharmalabs Limited An improved process for preparation of gemcitabine hydrochloride
KR101259637B1 (ko) * 2005-12-14 2013-04-30 주식회사종근당 1-(2´-데옥시-2´,2´-디플루오로-디-리보푸라노실)-4-아미노피리미딘-2-온또는 그의 염산염의 제조방법
US20090069354A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched gemcitabine
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
AU2008323923A1 (en) * 2007-11-06 2009-05-14 Pharmaessentia Corporation Novel synthesis of beta-nucleosides
IT1393062B1 (it) * 2008-10-23 2012-04-11 Prime Europ Therapeuticals Procedimento per la preparazione di gemcitabina cloridrato
ES2628609T3 (es) * 2009-04-06 2017-08-03 Otsuka Pharmaceutical Co., Ltd. Combinación de fármacos antineoplásicos a base de citidina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer
US8324180B2 (en) * 2009-04-06 2012-12-04 Eisai Inc. Compositions and methods for treating cancer
CA2757744C (en) * 2009-04-06 2018-02-13 Eisai Inc. Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
CN101525361B (zh) * 2009-04-21 2010-11-17 济南圣鲁金药物技术开发有限公司 基于吉西他滨结构的前药及其合成方法及应用
EP2431376B2 (en) * 2009-05-15 2024-02-07 Delta-Fly Pharma, Inc. Novel stable crystal of 1-(2'-cyano-2'-deoxy-beta -d-arabinofuranosyl)cytosine monohydrochloride
CN101628927B (zh) * 2009-08-07 2012-10-10 卡硼瑞（北京）科技有限公司 以1,3,5-三-O-苯甲酰基-α-D-呋喃核糖为原料立体选择性制备β-二氟胞苷盐酸盐的方法
CN102453064B (zh) * 2011-06-30 2014-07-09 江苏豪森药业股份有限公司 制备吉西他滨盐酸盐的方法
CN102659884B (zh) * 2012-04-23 2014-07-02 南京臣功制药股份有限公司 盐酸吉西他滨的提纯方法
CN103224541B (zh) * 2013-04-27 2015-07-01 江苏豪森药业股份有限公司 吉西他滨α-异构体转化回收工艺
CN104402945A (zh) * 2014-11-27 2015-03-11 苏州乔纳森新材料科技有限公司 一种3-脱氧-1,2-o-异丙叉-d-呋喃木糖的合成方法

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US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

Also Published As

Publication number Publication date
SI0719788T1 (en) 1999-10-31
ZA959320B (en) 1997-05-05
IL115852A0 (en) 1996-01-31
CN1169728A (zh) 1998-01-07
HU219021B (hu) 2001-01-29
RU2154648C2 (ru) 2000-08-20
KR100424991B1 (ko) 2004-05-20
ATE179986T1 (de) 1999-05-15
BG62738B1 (bg) 2000-06-30
TW379226B (en) 2000-01-11
YU70895A (sh) 1998-09-18
NO972679L (no) 1997-06-11
US5637688A (en) 1997-06-10
CZ290941B6 (cs) 2002-11-13
UA48152C2 (uk) 2002-08-15
GR3030265T3 (en) 1999-08-31
EP0719788B1 (en) 1999-05-12
EP0719788A3 (en) 1996-09-25
ES2130542T3 (es) 1999-07-01
IL115852A (en) 1999-09-22
US5808048A (en) 1998-09-15
NO972679D0 (no) 1997-06-11
CZ179897A3 (en) 1997-09-17
PL181732B1 (en) 2001-09-28
AR001041A1 (es) 1997-09-24
CO4520286A1 (es) 1997-10-15
AU689674B2 (en) 1998-04-02
PL321046A1 (en) 1997-11-24
CN1047177C (zh) 1999-12-08
EP0719788A2 (en) 1996-07-03
BR9509979A (pt) 1998-06-09
DE69509624D1 (de) 1999-06-17
RO117327B1 (ro) 2002-01-30
WO1996018637A1 (en) 1996-06-20
NZ296476A (en) 1998-12-23
BG101591A (en) 1998-03-31
PE49296A1 (es) 1996-11-21
DE69509624T2 (de) 1999-10-07
HUT77929A (hu) 1998-11-30
MY112488A (en) 2001-06-30
MX9704322A (es) 1997-09-30
NO306783B1 (no) 1999-12-20
JPH10510806A (ja) 1998-10-20
AU4110196A (en) 1996-07-03
DK0719788T3 (da) 1999-11-01

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