MX9704322A - Procedimiento para la preparacion de clorhidrato de 1-(2'-desoxi-2',2'-difluoro-d-ribofuranosilo)-4-aminopirimidin-2-ona. - Google Patents
Procedimiento para la preparacion de clorhidrato de 1-(2'-desoxi-2',2'-difluoro-d-ribofuranosilo)-4-aminopirimidin-2-ona.Info
- Publication number
- MX9704322A MX9704322A MX9704322A MX9704322A MX9704322A MX 9704322 A MX9704322 A MX 9704322A MX 9704322 A MX9704322 A MX 9704322A MX 9704322 A MX9704322 A MX 9704322A MX 9704322 A MX9704322 A MX 9704322A
- Authority
- MX
- Mexico
- Prior art keywords
- aminopyrimidin
- ribofuranosyl
- deoxy
- difluoro
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invencion provee un procedimiento para la preparacion de clorhidrato de gemcitabina el cual comprende desbloquear beta-1-(2'-desoxi-2', 2'-difluoro-3', 5'- di-O-benzoilo-D-ribofuranosilo)-4-aminopirimidin-2 -ona con una cantidad catalítica de una alquilamina en la presencia de metanol o etanol en un ambiente o un medio ambiente esencialmente libre de agua, tratando la solucion resultante con un ácido clorhídrico y un antisolvente, y recubriendo el solido resultante de clorhidrato de gamcitabina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08355372 | 1994-12-13 | ||
US08/355,372 US5637688A (en) | 1994-12-13 | 1994-12-13 | Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride |
PCT/US1995/014864 WO1996018637A1 (en) | 1994-12-13 | 1995-11-14 | Process for preparing 1-(2'-deoxy-2',2'-difluoro-d-ribofuranosyl-4-aminopyrimidin-2-one) hydrochloride |
Publications (2)
Publication Number | Publication Date |
---|---|
MX9704322A true MX9704322A (es) | 1997-09-30 |
MXPA97004322A MXPA97004322A (es) | 1998-07-03 |
Family
ID=
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY112488A (en) | Process for preparing 1-(2''-deoxy-2'',2''-difluoro-d- ribofuranosyl)-4-aminopyrimidin-one) hydrochloride | |
BR0015962A (pt) | Compostos tendo ligações multiplas que são agonistas de receptor adrenérgico (beta)2 úteis no tratamento e prevenção de doenças respiratórias | |
EP0629608A3 (en) | N-acyl-N, N ', N'-ethylenediamine triacetic acid derivatives and process for their preparation. | |
DE69500323D1 (de) | Antikorrosiver, kathodischer Elektrotauchlack | |
SI0712860T1 (en) | Process for purifying and isolating 2'-deoxy-2',2'-difluoronucleosides | |
DE69006290D1 (de) | N-Substituierte Benzyloxyiminderivate, Verfahren zu deren Herstellung und deren Verwendung. | |
CA2321461A1 (en) | Cross-linked high amylose starch having functional groups as a matrix for the slow release of pharmaceutical agents | |
NO961173L (no) | Nye pyrido(3,2-e)pyrazinoner med antiastmatisk virkning og fremgangsmåte for deres fremstilling | |
FR2663352B1 (fr) | Procede d'etanchement des liaisons entre palplanches, et palplanches permettant sa mise en óoeuvre. | |
EP0678576A3 (en) | Fructosyl amino acid oxidase and process for its preparation. | |
FR2697612B1 (fr) | Collier de serrage, notamment pour tuyaux flexibles. | |
ATE113056T1 (de) | Künstliche rezeptor-analoge. | |
BR9611249A (pt) | Composição pulverulenta redispersível em água processo de preparação da mesma pseudo-latéx e utilização do mesmo | |
AU7213196A (en) | Method of treating the navicular disease in horses | |
CA2207617A1 (en) | Process for preparing 1-(2'-deoxy-2',2'-difluoro-d-ribofuranosyl-4-aminopyrimidin-2-one) hydrochloride | |
BR9605647A (pt) | Eletrodo aperfeiçoado para ser usado em eletrolisadores de membrana | |
BR0206106A (pt) | Método de arilação para a funcionalização de derivados o-alil eritromicina | |
UA39178C2 (uk) | Спосіб мінімізації деградації активованого протеїну с (варіанти), фармацевтична композиція та водний розчин активованого протеїну с | |
FR2738246B1 (fr) | Procede de synthese du tetranitro-2,4,6,8-tetraaza-2,4,6,8-bicyclo(3.3.0)octane | |
ECSP951607A (es) | Procedimiento para preparar clorhidrato de 1-(2' - desoxi - 2', 2'- difluoro - d - ribofuranosil) - 4 - aminopirimidin - 2 - ona, case x - 8961 | |
DE3887710T2 (de) | 1-(3,5-Di-0-benzoyl-2-deoxy-beta-D-threo-pentofuranosyl)Thymine und Verfahren zu deren Herstellung. | |
NO893925L (no) | 1-metyl-3, 5, 7-triaza-1-azoniatricyklodekan trijodid, fremgangsmaate for fremstilling derav, og anvendelse derav ved bekjempelse av mikroorganismer i vandige systemer. | |
FR2663351B1 (fr) | Procede d'etanchement des liaisons entre palplanches, et palplanches permettant sa mise en óoeuvre. | |
ES1030105U (es) | Sistema de fijacion vertebral lumbar y sacra. | |
ES1038441U (es) | Garrainmovilizadora perfeccionada, aplicable sobre marcos de batientes en general. |