BG100765A - Метод за получаване на сол на клавуланова киселина - Google Patents

Метод за получаване на сол на клавуланова киселина

Info

Publication number
BG100765A
BG100765A BG100765A BG10076596A BG100765A BG 100765 A BG100765 A BG 100765A BG 100765 A BG100765 A BG 100765A BG 10076596 A BG10076596 A BG 10076596A BG 100765 A BG100765 A BG 100765A
Authority
BG
Bulgaria
Prior art keywords
salt
clavulanic acid
preparation
solution
organic solvent
Prior art date
Application number
BG100765A
Other languages
English (en)
Other versions
BG63307B1 (bg
Inventor
Michael Cook
Geoffrey WEBB
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of BG100765A publication Critical patent/BG100765A/bg
Publication of BG63307B1 publication Critical patent/BG63307B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Изобретението се отнася до метод, при който клавулановата киселина в разтвор в напълно или частичноводнонесмесваем органичен разтворител контактува в контактен регион на висока турбулентност и/или тангенциално завихряне със съединение - източник насол, за да образува разтвор на сол на тази киселина във водна фаза. След това органичният разтворител и водната фаза се разделят физически в етап на разделяне, а в следващия етап на обработване солтасе изолира от разтвора като твърдо вещество.
BG100765A 1994-02-02 1996-08-01 Метод за получаване на сол на клавуланова киселина BG63307B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9401969A GB9401969D0 (en) 1994-02-02 1994-02-02 Process
PCT/GB1995/000191 WO1995021173A1 (en) 1994-02-02 1995-01-31 Process for the preparation of a salt of clavulanic acid

Publications (2)

Publication Number Publication Date
BG100765A true BG100765A (bg) 1997-09-30
BG63307B1 BG63307B1 (bg) 2001-09-28

Family

ID=10749727

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100765A BG63307B1 (bg) 1994-02-02 1996-08-01 Метод за получаване на сол на клавуланова киселина

Country Status (32)

Country Link
US (1) US5965728A (bg)
EP (1) EP0741732B1 (bg)
JP (1) JP4074336B2 (bg)
KR (1) KR100388769B1 (bg)
CN (1) CN1065246C (bg)
AP (1) AP610A (bg)
AT (1) ATE202358T1 (bg)
AU (1) AU688849B2 (bg)
BG (1) BG63307B1 (bg)
BR (1) BR9506919A (bg)
CA (1) CA2182504C (bg)
CZ (1) CZ294005B6 (bg)
DE (1) DE69521415T2 (bg)
DK (1) DK0741732T3 (bg)
ES (1) ES2159626T3 (bg)
FI (1) FI111949B (bg)
GB (1) GB9401969D0 (bg)
GR (1) GR3036602T3 (bg)
HK (1) HK1012373A1 (bg)
HU (1) HU226597B1 (bg)
MX (1) MX9603204A (bg)
NO (1) NO314505B1 (bg)
NZ (1) NZ278927A (bg)
OA (1) OA10587A (bg)
PL (1) PL181451B1 (bg)
PT (1) PT741732E (bg)
RO (1) RO115730B1 (bg)
RU (1) RU2140418C1 (bg)
SI (1) SI0741732T1 (bg)
SK (1) SK282544B6 (bg)
UA (1) UA48944C2 (bg)
WO (1) WO1995021173A1 (bg)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
EP0867515B1 (en) * 1997-03-24 1999-12-08 CIPAN-Companhia Industrial Produtora De Antibioticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DZ2456A1 (fr) 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
DK1412078T3 (da) 2001-08-02 2009-02-02 Lg Life Sciences Ltd Fremgangsmåde til fremstilling af amino-beskyttede derivater af 4-aminomethylen-pyrrolidin-3-on, Gemifloxacin eller salte deraf
CN109715156A (zh) 2016-07-14 2019-05-03 尔察祯有限公司 用于治疗细菌感染的头孢布烯和克拉维酸的组合
CN108822134B (zh) * 2018-04-25 2021-06-25 国药集团威奇达药业有限公司 克拉维酸叔丁胺盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB8404749D0 (en) * 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor

Also Published As

Publication number Publication date
CA2182504C (en) 2008-04-08
JP4074336B2 (ja) 2008-04-09
ATE202358T1 (de) 2001-07-15
US5965728A (en) 1999-10-12
NZ278927A (en) 1998-02-26
RU2140418C1 (ru) 1999-10-27
NO963217L (no) 1996-10-01
OA10587A (en) 2002-07-10
SK100396A3 (en) 1996-12-04
NO963217D0 (no) 1996-08-01
WO1995021173A1 (en) 1995-08-10
CZ294005B6 (cs) 2004-09-15
AP9600838A0 (en) 1996-07-31
HUT74885A (en) 1997-02-28
HU226597B1 (en) 2009-04-28
RO115730B1 (ro) 2000-05-30
AU1541295A (en) 1995-08-21
HK1012373A1 (en) 1999-07-30
FI111949B (fi) 2003-10-15
UA48944C2 (uk) 2002-09-16
MX9603204A (es) 1997-03-29
FI963050A (fi) 1996-10-01
PT741732E (pt) 2001-11-30
PL315782A1 (en) 1996-12-09
GB9401969D0 (en) 1994-03-30
GR3036602T3 (en) 2001-12-31
CZ229496A3 (en) 1997-01-15
HU9602128D0 (en) 1996-09-30
KR100388769B1 (ko) 2003-09-02
DE69521415T2 (de) 2002-05-29
EP0741732A1 (en) 1996-11-13
JPH09508411A (ja) 1997-08-26
AP610A (en) 1997-09-04
CN1065246C (zh) 2001-05-02
AU688849B2 (en) 1998-03-19
DK0741732T3 (da) 2001-10-15
ES2159626T3 (es) 2001-10-16
BR9506919A (pt) 1997-09-30
DE69521415D1 (de) 2001-07-26
PL181451B1 (en) 2001-07-31
FI963050A0 (fi) 1996-08-01
SI0741732T1 (bg) 2001-10-31
EP0741732B1 (en) 2001-06-20
CA2182504A1 (en) 1995-08-10
BG63307B1 (bg) 2001-09-28
CN1144528A (zh) 1997-03-05
NO314505B1 (no) 2003-03-31
SK282544B6 (sk) 2002-10-08

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