DE69521415T2 - Verfahren zur herstellung eines clavulansäuresalzes - Google Patents

Verfahren zur herstellung eines clavulansäuresalzes

Info

Publication number
DE69521415T2
DE69521415T2 DE69521415T DE69521415T DE69521415T2 DE 69521415 T2 DE69521415 T2 DE 69521415T2 DE 69521415 T DE69521415 T DE 69521415T DE 69521415 T DE69521415 T DE 69521415T DE 69521415 T2 DE69521415 T2 DE 69521415T2
Authority
DE
Germany
Prior art keywords
producing
acid salt
clavulanic acid
clavulanic
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69521415T
Other languages
English (en)
Other versions
DE69521415D1 (de
Inventor
Alan Cook
Clive Webb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE69521415D1 publication Critical patent/DE69521415D1/de
Application granted granted Critical
Publication of DE69521415T2 publication Critical patent/DE69521415T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69521415T 1994-02-02 1995-01-31 Verfahren zur herstellung eines clavulansäuresalzes Expired - Lifetime DE69521415T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9401969A GB9401969D0 (en) 1994-02-02 1994-02-02 Process
PCT/GB1995/000191 WO1995021173A1 (en) 1994-02-02 1995-01-31 Process for the preparation of a salt of clavulanic acid

Publications (2)

Publication Number Publication Date
DE69521415D1 DE69521415D1 (de) 2001-07-26
DE69521415T2 true DE69521415T2 (de) 2002-05-29

Family

ID=10749727

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69521415T Expired - Lifetime DE69521415T2 (de) 1994-02-02 1995-01-31 Verfahren zur herstellung eines clavulansäuresalzes

Country Status (32)

Country Link
US (1) US5965728A (de)
EP (1) EP0741732B1 (de)
JP (1) JP4074336B2 (de)
KR (1) KR100388769B1 (de)
CN (1) CN1065246C (de)
AP (1) AP610A (de)
AT (1) ATE202358T1 (de)
AU (1) AU688849B2 (de)
BG (1) BG63307B1 (de)
BR (1) BR9506919A (de)
CA (1) CA2182504C (de)
CZ (1) CZ294005B6 (de)
DE (1) DE69521415T2 (de)
DK (1) DK0741732T3 (de)
ES (1) ES2159626T3 (de)
FI (1) FI111949B (de)
GB (1) GB9401969D0 (de)
GR (1) GR3036602T3 (de)
HK (1) HK1012373A1 (de)
HU (1) HU226597B1 (de)
MX (1) MX9603204A (de)
NO (1) NO314505B1 (de)
NZ (1) NZ278927A (de)
OA (1) OA10587A (de)
PL (1) PL181451B1 (de)
PT (1) PT741732E (de)
RO (1) RO115730B1 (de)
RU (1) RU2140418C1 (de)
SI (1) SI0741732T1 (de)
SK (1) SK282544B6 (de)
UA (1) UA48944C2 (de)
WO (1) WO1995021173A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
DK0867515T3 (da) * 1997-03-24 2000-06-13 Cipan Comp Ind Prod Fremgangsmåde til isolering af et farmaceutisk acceptabelt alkalimetalsalt af clavulansyre
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
JP2005500350A (ja) 2001-08-02 2005-01-06 エルジー ライフサイエンス リミテッド ４−アミノメチレン−ピロリジン−３−オンおよび／または４−アミノメチレン−ピロリジン−３−アルコキシイミノ誘導体のアミノ保護誘導体、および／またはジェミフロキサシンまたはその塩の製造方法
US10624899B2 (en) 2016-07-14 2020-04-21 Achaogen, Inc. Combination products for the treatment of bacterial infections and methods of producing or dosing of same
CN108822134B (zh) * 2018-04-25 2021-06-25 国药集团威奇达药业有限公司 克拉维酸叔丁胺盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB8404749D0 (en) * 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor

Also Published As

Publication number Publication date
CN1144528A (zh) 1997-03-05
PT741732E (pt) 2001-11-30
NZ278927A (en) 1998-02-26
SK100396A3 (en) 1996-12-04
PL181451B1 (en) 2001-07-31
CZ229496A3 (en) 1997-01-15
NO314505B1 (no) 2003-03-31
SK282544B6 (sk) 2002-10-08
BG100765A (en) 1997-09-30
UA48944C2 (uk) 2002-09-16
WO1995021173A1 (en) 1995-08-10
HUT74885A (en) 1997-02-28
EP0741732A1 (de) 1996-11-13
ATE202358T1 (de) 2001-07-15
DE69521415D1 (de) 2001-07-26
KR100388769B1 (ko) 2003-09-02
HU226597B1 (en) 2009-04-28
EP0741732B1 (de) 2001-06-20
US5965728A (en) 1999-10-12
FI963050A (fi) 1996-10-01
CZ294005B6 (cs) 2004-09-15
BG63307B1 (bg) 2001-09-28
HU9602128D0 (en) 1996-09-30
AP9600838A0 (en) 1996-07-31
ES2159626T3 (es) 2001-10-16
JP4074336B2 (ja) 2008-04-09
JPH09508411A (ja) 1997-08-26
CN1065246C (zh) 2001-05-02
RO115730B1 (ro) 2000-05-30
AU688849B2 (en) 1998-03-19
RU2140418C1 (ru) 1999-10-27
FI963050A0 (fi) 1996-08-01
DK0741732T3 (da) 2001-10-15
HK1012373A1 (en) 1999-07-30
NO963217L (no) 1996-10-01
NO963217D0 (no) 1996-08-01
FI111949B (fi) 2003-10-15
GR3036602T3 (en) 2001-12-31
GB9401969D0 (en) 1994-03-30
OA10587A (en) 2002-07-10
CA2182504A1 (en) 1995-08-10
BR9506919A (pt) 1997-09-30
AU1541295A (en) 1995-08-21
AP610A (en) 1997-09-04
MX9603204A (es) 1997-03-29
PL315782A1 (en) 1996-12-09
SI0741732T1 (de) 2001-10-31
CA2182504C (en) 2008-04-08

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8364 No opposition during term of opposition