FI111949B - Menetelmä kaliumklavulanaatin valmistamiseksi - Google Patents

Menetelmä kaliumklavulanaatin valmistamiseksi Download PDF

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Publication number
FI111949B
FI111949B FI963050A FI963050A FI111949B FI 111949 B FI111949 B FI 111949B FI 963050 A FI963050 A FI 963050A FI 963050 A FI963050 A FI 963050A FI 111949 B FI111949 B FI 111949B
Authority
FI
Finland
Prior art keywords
solution
water
clavulanic acid
organic solvent
potassium
Prior art date
Application number
FI963050A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963050A (fi
FI963050A0 (fi
Inventor
Michael Alan Cook
Geoffrey Clive Webb
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of FI963050A0 publication Critical patent/FI963050A0/fi
Publication of FI963050A publication Critical patent/FI963050A/fi
Application granted granted Critical
Publication of FI111949B publication Critical patent/FI111949B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
FI963050A 1994-02-02 1996-08-01 Menetelmä kaliumklavulanaatin valmistamiseksi FI111949B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9401969 1994-02-02
GB9401969A GB9401969D0 (en) 1994-02-02 1994-02-02 Process
PCT/GB1995/000191 WO1995021173A1 (en) 1994-02-02 1995-01-31 Process for the preparation of a salt of clavulanic acid
GB9500191 1995-01-31

Publications (3)

Publication Number Publication Date
FI963050A0 FI963050A0 (fi) 1996-08-01
FI963050A FI963050A (fi) 1996-10-01
FI111949B true FI111949B (fi) 2003-10-15

Family

ID=10749727

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963050A FI111949B (fi) 1994-02-02 1996-08-01 Menetelmä kaliumklavulanaatin valmistamiseksi

Country Status (32)

Country Link
US (1) US5965728A (de)
EP (1) EP0741732B1 (de)
JP (1) JP4074336B2 (de)
KR (1) KR100388769B1 (de)
CN (1) CN1065246C (de)
AP (1) AP610A (de)
AT (1) ATE202358T1 (de)
AU (1) AU688849B2 (de)
BG (1) BG63307B1 (de)
BR (1) BR9506919A (de)
CA (1) CA2182504C (de)
CZ (1) CZ294005B6 (de)
DE (1) DE69521415T2 (de)
DK (1) DK0741732T3 (de)
ES (1) ES2159626T3 (de)
FI (1) FI111949B (de)
GB (1) GB9401969D0 (de)
GR (1) GR3036602T3 (de)
HK (1) HK1012373A1 (de)
HU (1) HU226597B1 (de)
MX (1) MX9603204A (de)
NO (1) NO314505B1 (de)
NZ (1) NZ278927A (de)
OA (1) OA10587A (de)
PL (1) PL181451B1 (de)
PT (1) PT741732E (de)
RO (1) RO115730B1 (de)
RU (1) RU2140418C1 (de)
SI (1) SI0741732T1 (de)
SK (1) SK282544B6 (de)
UA (1) UA48944C2 (de)
WO (1) WO1995021173A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DK0867515T3 (da) 1997-03-24 2000-06-13 Cipan Comp Ind Prod Fremgangsmåde til isolering af et farmaceutisk acceptabelt alkalimetalsalt af clavulansyre
DZ2456A1 (fr) 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
ES2314082T3 (es) 2001-08-02 2009-03-16 Lg Life Sciences Limited Procedimientos para la produccion de derivados amino protegidos de 4-aminometilenpirrolidin-3-ona, gemifloxacina y sus sales.
WO2018013870A1 (en) 2016-07-14 2018-01-18 Achaogen, Inc. Combination of ceftibuten and clavulanic acid for use in the treatment of bacterial infections
CN108822134B (zh) * 2018-04-25 2021-06-25 国药集团威奇达药业有限公司 克拉维酸叔丁胺盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB8404749D0 (en) * 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor

Also Published As

Publication number Publication date
GR3036602T3 (en) 2001-12-31
ES2159626T3 (es) 2001-10-16
OA10587A (en) 2002-07-10
DE69521415T2 (de) 2002-05-29
MX9603204A (es) 1997-03-29
JP4074336B2 (ja) 2008-04-09
CZ229496A3 (en) 1997-01-15
HU226597B1 (en) 2009-04-28
AU1541295A (en) 1995-08-21
GB9401969D0 (en) 1994-03-30
CZ294005B6 (cs) 2004-09-15
BG63307B1 (bg) 2001-09-28
NO963217D0 (no) 1996-08-01
AP9600838A0 (en) 1996-07-31
AU688849B2 (en) 1998-03-19
EP0741732A1 (de) 1996-11-13
US5965728A (en) 1999-10-12
SK100396A3 (en) 1996-12-04
FI963050A (fi) 1996-10-01
HUT74885A (en) 1997-02-28
PL181451B1 (en) 2001-07-31
HU9602128D0 (en) 1996-09-30
EP0741732B1 (de) 2001-06-20
RO115730B1 (ro) 2000-05-30
NO963217L (no) 1996-10-01
ATE202358T1 (de) 2001-07-15
CN1065246C (zh) 2001-05-02
UA48944C2 (uk) 2002-09-16
NO314505B1 (no) 2003-03-31
SK282544B6 (sk) 2002-10-08
HK1012373A1 (en) 1999-07-30
CA2182504A1 (en) 1995-08-10
PT741732E (pt) 2001-11-30
BR9506919A (pt) 1997-09-30
RU2140418C1 (ru) 1999-10-27
DE69521415D1 (de) 2001-07-26
WO1995021173A1 (en) 1995-08-10
AP610A (en) 1997-09-04
BG100765A (en) 1997-09-30
JPH09508411A (ja) 1997-08-26
PL315782A1 (en) 1996-12-09
KR100388769B1 (ko) 2003-09-02
SI0741732T1 (de) 2001-10-31
FI963050A0 (fi) 1996-08-01
DK0741732T3 (da) 2001-10-15
CA2182504C (en) 2008-04-08
NZ278927A (en) 1998-02-26
CN1144528A (zh) 1997-03-05

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