UA48944C2 - Спосіб одержання солі клавуланової кислоти - Google Patents

Спосіб одержання солі клавуланової кислоти

Info

Publication number
UA48944C2
UA48944C2 UA96083392A UA96083392A UA48944C2 UA 48944 C2 UA48944 C2 UA 48944C2 UA 96083392 A UA96083392 A UA 96083392A UA 96083392 A UA96083392 A UA 96083392A UA 48944 C2 UA48944 C2 UA 48944C2
Authority
UA
Ukraine
Prior art keywords
salt
clavulanic acid
preparation
solution
acid
Prior art date
Application number
UA96083392A
Other languages
English (en)
Russian (ru)
Inventor
Майкл Алан Кук
Джеффрі Клів Вебб
Original Assignee
Смітклайн Бічам Плс
Смитклайн Бичам Плс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смітклайн Бічам Плс, Смитклайн Бичам Плс filed Critical Смітклайн Бічам Плс
Publication of UA48944C2 publication Critical patent/UA48944C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

У даному винаході запропоновано спосіб отримання солі клавуланової кислоти, у якому клавуланова кислота в розчині органічного розчинника, що цілком або частково не змішується з водою, контактує в зоні високої турбулентності та/чи напруги зрушення зі сполукою солі-попередника, щоб утворити розчин солі клавуланової кислоти у водяній фазі. Потім органічний розчинник і водяні фази фізично розділяються на стадії поділу, за якою йде подальша стадія обробки, в якій зазначена сіль клавуланової кислоти виділяється з розчину у вигляді твердої речовини.
UA96083392A 1994-02-02 1995-01-31 Спосіб одержання солі клавуланової кислоти UA48944C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9401969A GB9401969D0 (en) 1994-02-02 1994-02-02 Process
PCT/GB1995/000191 WO1995021173A1 (en) 1994-02-02 1995-01-31 Process for the preparation of a salt of clavulanic acid

Publications (1)

Publication Number Publication Date
UA48944C2 true UA48944C2 (uk) 2002-09-16

Family

ID=10749727

Family Applications (1)

Application Number Title Priority Date Filing Date
UA96083392A UA48944C2 (uk) 1994-02-02 1995-01-31 Спосіб одержання солі клавуланової кислоти

Country Status (32)

Country Link
US (1) US5965728A (uk)
EP (1) EP0741732B1 (uk)
JP (1) JP4074336B2 (uk)
KR (1) KR100388769B1 (uk)
CN (1) CN1065246C (uk)
AP (1) AP610A (uk)
AT (1) ATE202358T1 (uk)
AU (1) AU688849B2 (uk)
BG (1) BG63307B1 (uk)
BR (1) BR9506919A (uk)
CA (1) CA2182504C (uk)
CZ (1) CZ294005B6 (uk)
DE (1) DE69521415T2 (uk)
DK (1) DK0741732T3 (uk)
ES (1) ES2159626T3 (uk)
FI (1) FI111949B (uk)
GB (1) GB9401969D0 (uk)
GR (1) GR3036602T3 (uk)
HK (1) HK1012373A1 (uk)
HU (1) HU226597B1 (uk)
MX (1) MX9603204A (uk)
NO (1) NO314505B1 (uk)
NZ (1) NZ278927A (uk)
OA (1) OA10587A (uk)
PL (1) PL181451B1 (uk)
PT (1) PT741732E (uk)
RO (1) RO115730B1 (uk)
RU (1) RU2140418C1 (uk)
SI (1) SI0741732T1 (uk)
SK (1) SK282544B6 (uk)
UA (1) UA48944C2 (uk)
WO (1) WO1995021173A1 (uk)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
US6414142B1 (en) 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
DK0867515T3 (da) * 1997-03-24 2000-06-13 Cipan Comp Ind Prod Fremgangsmåde til isolering af et farmaceutisk acceptabelt alkalimetalsalt af clavulansyre
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
US7199242B2 (en) 2001-08-02 2007-04-03 Lg Life Sciences Limited Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof
EP3484472A1 (en) 2016-07-14 2019-05-22 Achaogen, Inc. Combination of ceftibuten and clavulanic acid for use in the treatment of bacterial infections
CN108822134B (zh) * 2018-04-25 2021-06-25 国药集团威奇达药业有限公司 克拉维酸叔丁胺盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB8404749D0 (en) * 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor

Also Published As

Publication number Publication date
CZ294005B6 (cs) 2004-09-15
AP610A (en) 1997-09-04
NO314505B1 (no) 2003-03-31
SK282544B6 (sk) 2002-10-08
RO115730B1 (ro) 2000-05-30
BG63307B1 (bg) 2001-09-28
EP0741732A1 (en) 1996-11-13
JP4074336B2 (ja) 2008-04-09
CN1065246C (zh) 2001-05-02
AU1541295A (en) 1995-08-21
PL315782A1 (en) 1996-12-09
OA10587A (en) 2002-07-10
DK0741732T3 (da) 2001-10-15
PT741732E (pt) 2001-11-30
CZ229496A3 (en) 1997-01-15
US5965728A (en) 1999-10-12
ES2159626T3 (es) 2001-10-16
NZ278927A (en) 1998-02-26
EP0741732B1 (en) 2001-06-20
DE69521415D1 (de) 2001-07-26
HU9602128D0 (en) 1996-09-30
ATE202358T1 (de) 2001-07-15
NO963217L (no) 1996-10-01
AU688849B2 (en) 1998-03-19
FI111949B (fi) 2003-10-15
CN1144528A (zh) 1997-03-05
HUT74885A (en) 1997-02-28
CA2182504A1 (en) 1995-08-10
DE69521415T2 (de) 2002-05-29
WO1995021173A1 (en) 1995-08-10
SK100396A3 (en) 1996-12-04
BR9506919A (pt) 1997-09-30
KR100388769B1 (ko) 2003-09-02
HU226597B1 (en) 2009-04-28
GB9401969D0 (en) 1994-03-30
FI963050A0 (fi) 1996-08-01
CA2182504C (en) 2008-04-08
BG100765A (en) 1997-09-30
HK1012373A1 (en) 1999-07-30
RU2140418C1 (ru) 1999-10-27
PL181451B1 (en) 2001-07-31
SI0741732T1 (uk) 2001-10-31
NO963217D0 (no) 1996-08-01
MX9603204A (es) 1997-03-29
FI963050A (fi) 1996-10-01
AP9600838A0 (en) 1996-07-31
GR3036602T3 (en) 2001-12-31
JPH09508411A (ja) 1997-08-26

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