BR9808941A - Processo aprimorado para a produção fermentativa de penicilina - Google Patents

Processo aprimorado para a produção fermentativa de penicilina

Info

Publication number
BR9808941A
BR9808941A BR9808941-2A BR9808941A BR9808941A BR 9808941 A BR9808941 A BR 9808941A BR 9808941 A BR9808941 A BR 9808941A BR 9808941 A BR9808941 A BR 9808941A
Authority
BR
Brazil
Prior art keywords
apa
penicillin
improved process
extraction
organic solvent
Prior art date
Application number
BR9808941-2A
Other languages
English (en)
Inventor
Pieter Theodorus Kerkhof
Rienk Hendrik Kuipers
Hubertus Gerardus Mar Walraven
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8228240&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9808941(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dsm Nv filed Critical Dsm Nv
Publication of BR9808941A publication Critical patent/BR9808941A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"PROCESSO APRIMORADO PARA A PRODUçãO FERMENTATIVA DE PENICILINA" A presente invenção revela um processo aprimorado para a preparação do ácido 6-amino penicilínico (6-APA) a partir de uma penicilina N-substituída fermentativamente produzida e que compreende as etapas de extração do composto de penicilina N-substituída como presente em uma calda ou fluido de fermentação por um solvente orgânico, a re-extração do composto de penicilina N-substituída em água, o tratamento da fase aquosa com uma acilase de penicilina e o isolamento do 6-APA a partir da assim obtida solução de conversão por cristalização. As melhorias adicionais compreendem a extração da cadeia lateral em um solvente orgânico e o isolamento do 6-APA a partir da assim obtida fase aquosa pelo uso de um processo específico de cristalização.
BR9808941-2A 1997-04-22 1998-04-22 Processo aprimorado para a produção fermentativa de penicilina BR9808941A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97201200 1997-04-22
PCT/EP1998/002462 WO1998048039A1 (en) 1997-04-22 1998-04-22 Improved process for the fermentative production of penicillin

Publications (1)

Publication Number Publication Date
BR9808941A true BR9808941A (pt) 2000-08-01

Family

ID=8228240

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9808941-2A BR9808941A (pt) 1997-04-22 1998-04-22 Processo aprimorado para a produção fermentativa de penicilina

Country Status (16)

Country Link
US (1) US20020058302A1 (pt)
EP (2) EP0977883B2 (pt)
JP (1) JP2001521396A (pt)
KR (1) KR20010012081A (pt)
CN (1) CN1187454C (pt)
AT (1) ATE278800T1 (pt)
AU (1) AU7432198A (pt)
BR (1) BR9808941A (pt)
DE (2) DE69826852T8 (pt)
ES (1) ES2224392T5 (pt)
ID (1) ID25658A (pt)
PL (1) PL336385A1 (pt)
PT (1) PT977883E (pt)
RU (1) RU2223323C2 (pt)
SI (1) SI0977883T2 (pt)
WO (1) WO1998048039A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002018618A2 (en) * 2000-08-28 2002-03-07 Dsm N.V. PROCESS FOR THE PREPARATION OF A β-LACTAM NUCLEUS AND THE APPLICATION THEREOF
JP2002316991A (ja) * 2001-04-18 2002-10-31 Otsuka Chem Co Ltd ペニシリン及びセファロスポリン化合物
EA017121B1 (ru) * 2005-12-02 2012-10-30 Дсм Синокем Фармасьютикалз Нидерландз Б.В. Способ получения калиевой соли пенициллина g
CN101321771B (zh) * 2005-12-02 2012-05-30 中化帝斯曼制药有限公司荷兰公司 青霉素钾盐的制备工艺
WO2014072843A1 (en) * 2012-11-07 2014-05-15 Vardhman Chemtech Limited Process for preparing isoxazolyl penicillins
CN102925526B (zh) * 2012-11-23 2014-10-15 华北制药河北华民药业有限责任公司 一种6-氨基青霉烷酸的制备方法
CN103695447B (zh) * 2013-11-11 2015-10-14 华北制药河北华民药业有限责任公司 一种新型内酰胺类抗生素合成酶及其编码基因和应用
CN104099396B (zh) * 2014-07-22 2016-03-23 石药集团中诺药业（石家庄）有限公司 一种直通法制备阿莫西林的工艺
CN104357504A (zh) * 2014-10-30 2015-02-18 青岛科技大学 一种细胞催化生产手性甲氧基吡啶乙醇
CN105732663B (zh) * 2016-03-28 2018-03-16 西藏百年汉克药业有限公司 6‑氨基青霉烷酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1299883A (fr) * 1961-09-06 1962-07-27 Pfizer & Co C Perfectionnements apportés aux procédés pour séparer des amino-acides amphotères de leurs solutions aqueuses
FR2188607A5 (en) * 1972-06-12 1974-01-18 Aries Robert 6-Aminopenicillanic acid prodn - by treatment of benzylpenicillin with amido-hydrolase 3-5-2
JPS57501610A (pt) * 1980-10-23 1982-09-09
NL8301373A (nl) * 1983-04-19 1984-11-16 Tno Geimmobiliseerde biokatalysatoren.
DE3729338A1 (de) * 1987-09-02 1989-03-23 Biotechnolog Forschung Gmbh Verfahren zur abtrennung von penicillin g aus einem fermentationsmedium durch extraktion
DE4005366A1 (de) * 1990-02-21 1991-08-22 Schott Glaswerke Extraktionsverfahren mit zwei nicht oder nur begrenzt miteinander mischbaren fluessigen phasen
ES2105989B1 (es) * 1996-03-15 1998-07-01 Antibioticos Sa Procedimiento alternativo para la obtencion del acido 6-amino penicilanico (6-apa).

Also Published As

Publication number Publication date
DE69826852D1 (de) 2004-11-11
ID25658A (id) 2000-10-19
JP2001521396A (ja) 2001-11-06
DE69826852T3 (de) 2008-02-14
CN1253594A (zh) 2000-05-17
EP0977883A1 (en) 2000-02-09
RU2223323C2 (ru) 2004-02-10
ATE278800T1 (de) 2004-10-15
CN1187454C (zh) 2005-02-02
DE69826852T2 (de) 2005-11-17
EP0977883B2 (en) 2007-08-01
AU7432198A (en) 1998-11-13
EP1475444A1 (en) 2004-11-10
US20020058302A1 (en) 2002-05-16
PT977883E (pt) 2005-01-31
PL336385A1 (en) 2000-06-19
KR20010012081A (ko) 2001-02-15
SI0977883T1 (en) 2005-02-28
SI0977883T2 (sl) 2007-12-31
EP0977883B1 (en) 2004-10-06
ES2224392T3 (es) 2005-03-01
DE69826852T8 (de) 2008-10-30
WO1998048039A1 (en) 1998-10-29
ES2224392T5 (es) 2008-03-01

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Free format text: DSM IP ASSETS B.V. (NL)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1937 DE 19/02/2008