DE69826852D1 - Verbessertes verfahren zur fermentativer herstellung von penizillin - Google Patents

Verbessertes verfahren zur fermentativer herstellung von penizillin

Info

Publication number
DE69826852D1
DE69826852D1 DE69826852A DE69826852A DE69826852D1 DE 69826852 D1 DE69826852 D1 DE 69826852D1 DE 69826852 A DE69826852 A DE 69826852A DE 69826852 A DE69826852 A DE 69826852A DE 69826852 D1 DE69826852 D1 DE 69826852D1
Authority
DE
Germany
Prior art keywords
apa
extraction
penicilline
penicillin
improved method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69826852A
Other languages
English (en)
Other versions
DE69826852T3 (de
DE69826852T8 (de
DE69826852T2 (de
Inventor
Theodorus Kerkhof
Hendrik Kuipers
Gerardus Walraven
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8228240&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69826852(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of DE69826852D1 publication Critical patent/DE69826852D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position
DE69826852A 1997-04-22 1998-04-22 Verbessertes verfahren zur fermentativer herstellung von penizillin Expired - Lifetime DE69826852D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97201200 1997-04-22
PCT/EP1998/002462 WO1998048039A1 (en) 1997-04-22 1998-04-22 Improved process for the fermentative production of penicillin

Publications (1)

Publication Number Publication Date
DE69826852D1 true DE69826852D1 (de) 2004-11-11

Family

ID=8228240

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69826852T Active DE69826852T8 (de) 1997-04-22 1998-04-22 Verbessertes verfahren zur fermentativen herstellung von penicillin
DE69826852A Expired - Lifetime DE69826852D1 (de) 1997-04-22 1998-04-22 Verbessertes verfahren zur fermentativer herstellung von penizillin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69826852T Active DE69826852T8 (de) 1997-04-22 1998-04-22 Verbessertes verfahren zur fermentativen herstellung von penicillin

Country Status (16)

Country Link
US (1) US20020058302A1 (de)
EP (2) EP1475444A1 (de)
JP (1) JP2001521396A (de)
KR (1) KR20010012081A (de)
CN (1) CN1187454C (de)
AT (1) ATE278800T1 (de)
AU (1) AU7432198A (de)
BR (1) BR9808941A (de)
DE (2) DE69826852T8 (de)
ES (1) ES2224392T5 (de)
ID (1) ID25658A (de)
PL (1) PL336385A1 (de)
PT (1) PT977883E (de)
RU (1) RU2223323C2 (de)
SI (1) SI0977883T2 (de)
WO (1) WO1998048039A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1303217C (zh) * 2000-08-28 2007-03-07 Dsm公司 β－内酰胺环的制备方法及其应用
JP2002316991A (ja) * 2001-04-18 2002-10-31 Otsuka Chem Co Ltd ペニシリン及びセファロスポリン化合物
CN101321771B (zh) * 2005-12-02 2012-05-30 中化帝斯曼制药有限公司荷兰公司 青霉素钾盐的制备工艺
EP1957502A1 (de) 2005-12-02 2008-08-20 DSMIP Assets B.V. Verfahren zur herstellung eines kaliumsalzes von penicillin
WO2014072843A1 (en) * 2012-11-07 2014-05-15 Vardhman Chemtech Limited Process for preparing isoxazolyl penicillins
CN102925526B (zh) * 2012-11-23 2014-10-15 华北制药河北华民药业有限责任公司 一种6-氨基青霉烷酸的制备方法
CN103695447B (zh) * 2013-11-11 2015-10-14 华北制药河北华民药业有限责任公司 一种新型内酰胺类抗生素合成酶及其编码基因和应用
CN104099396B (zh) * 2014-07-22 2016-03-23 石药集团中诺药业（石家庄）有限公司 一种直通法制备阿莫西林的工艺
CN104357504A (zh) * 2014-10-30 2015-02-18 青岛科技大学 一种细胞催化生产手性甲氧基吡啶乙醇
CN105732663B (zh) * 2016-03-28 2018-03-16 西藏百年汉克药业有限公司 6‑氨基青霉烷酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1299883A (fr) * 1961-09-06 1962-07-27 Pfizer & Co C Perfectionnements apportés aux procédés pour séparer des amino-acides amphotères de leurs solutions aqueuses
FR2188607A5 (en) * 1972-06-12 1974-01-18 Aries Robert 6-Aminopenicillanic acid prodn - by treatment of benzylpenicillin with amido-hydrolase 3-5-2
WO1982001563A1 (en) * 1980-10-23 1982-05-13 Bo Mattiasson Biological and chemical conversion processes in liquid phase-system
NL8301373A (nl) * 1983-04-19 1984-11-16 Tno Geimmobiliseerde biokatalysatoren.
DE3729338A1 (de) * 1987-09-02 1989-03-23 Biotechnolog Forschung Gmbh Verfahren zur abtrennung von penicillin g aus einem fermentationsmedium durch extraktion
DE4005366A1 (de) * 1990-02-21 1991-08-22 Schott Glaswerke Extraktionsverfahren mit zwei nicht oder nur begrenzt miteinander mischbaren fluessigen phasen
ES2105989B1 (es) * 1996-03-15 1998-07-01 Antibioticos Sa Procedimiento alternativo para la obtencion del acido 6-amino penicilanico (6-apa).

Also Published As

Publication number Publication date
AU7432198A (en) 1998-11-13
PT977883E (pt) 2005-01-31
ES2224392T3 (es) 2005-03-01
DE69826852T3 (de) 2008-02-14
JP2001521396A (ja) 2001-11-06
EP0977883A1 (de) 2000-02-09
ATE278800T1 (de) 2004-10-15
ID25658A (id) 2000-10-19
RU2223323C2 (ru) 2004-02-10
BR9808941A (pt) 2000-08-01
EP0977883B2 (de) 2007-08-01
DE69826852T8 (de) 2008-10-30
PL336385A1 (en) 2000-06-19
EP1475444A1 (de) 2004-11-10
EP0977883B1 (de) 2004-10-06
KR20010012081A (ko) 2001-02-15
CN1187454C (zh) 2005-02-02
SI0977883T1 (en) 2005-02-28
US20020058302A1 (en) 2002-05-16
WO1998048039A1 (en) 1998-10-29
ES2224392T5 (es) 2008-03-01
CN1253594A (zh) 2000-05-17
DE69826852T2 (de) 2005-11-17
SI0977883T2 (sl) 2007-12-31

Similar Documents

Publication Publication Date Title
HUP0300073A2 (en) Method of purifying a fermentation broth
DE69826852D1 (de) Verbessertes verfahren zur fermentativer herstellung von penizillin
ATE296357T1 (de) Verfahren zur herstellung von hochreinen hmg-coa reductase inhibitoren
RU99124595A (ru) Улучшенный способ ферментативного производства пенициллина
UA48944C2 (uk) Спосіб одержання солі клавуланової кислоти
ES2105989A1 (es) Procedimiento alternativo para la obtencion del acido 6-amino penicilanico (6-apa).
ATE269906T1 (de) Verbesserungen bezogen auf die herstellung von lactamverbindungen
ATE288962T1 (de) Verbessertes verfahren zur fermentativen herstellung von cephalosporin
ID26888A (id) Proses produksi fermentasi cephalosporin
DE60001737T2 (de) Verfahren zur herstellung von beta-laktamderivaten
WO1999012958A3 (de) Ampullosporin, verfahren zu dessen herstellung und dessen verwendung
ATE319849T1 (de) Verfahren zur herstellung vom ampicillin
IE41292L (en) Aminoacyl penicillins
ATE145670T1 (de) Verfahren zur fermentativen herstellung von 2- hydroxyphenylessigsäure
GB1459294A (en) Isolation of 6-aminopenicillanic acid and salts thereof
Keri et al. Method of purifying statins from a fermentation broth
GB883329A (en) Process for the production of alkaloid derivatives of lyserqic acid
HUT46060A (en) Process for producing pig liver esterase

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
R082 Change of representative

Ref document number: 977883

Country of ref document: EP

Representative=s name: DIEHL & PARTNER GBR, 80333 MUENCHEN, DE