GB883329A - Process for the production of alkaloid derivatives of lyserqic acid - Google Patents

Process for the production of alkaloid derivatives of lyserqic acid

Info

Publication number
GB883329A
GB883329A GB23303/60A GB2330360A GB883329A GB 883329 A GB883329 A GB 883329A GB 23303/60 A GB23303/60 A GB 23303/60A GB 2330360 A GB2330360 A GB 2330360A GB 883329 A GB883329 A GB 883329A
Authority
GB
United Kingdom
Prior art keywords
acid
lysergic
embryos
isolysergic
alkaloid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23303/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of GB883329A publication Critical patent/GB883329A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/183—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing an indolo[4,3-F,G]quinoleine nucleus, e.g. compound containing the lysergic acid nucleus as well as the dimeric ergot nucleus

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Lysergic acid amide and isolysergic acid amide are prepared by fermenting under aerobic conditions an aqueous nutrient medium containing a source of carbon, nitrogen and mineral salt with a new strain of Claviceps paspali Stevens and Hall. The process is preferably conducted between 22 DEG C. and 30 DEG C. and at a pH between 4.2 and 6, the alkaloid derivatives being isolated by filtration, rendering the filtrate alkaline, extracting with a water-immiscible organic solvent or by absorbtion on a solid absorbant material. Subsequent hydrolysis with alkali yields lysergic acid or isolysergic acid. The new virulented strain of Claviceps paspali is obtained by inoculating embryos of Rosen 4n rye, cultivating in vitro and isolating the sub-species from sclerotia on the embryos. Detailed examples illustrate the preparation of the alkaloids and their hydrolysis to lysergic and isolysergic acid.
GB23303/60A 1959-07-07 1960-07-04 Process for the production of alkaloid derivatives of lyserqic acid Expired GB883329A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT883329X 1959-07-07

Publications (1)

Publication Number Publication Date
GB883329A true GB883329A (en) 1961-11-29

Family

ID=11331122

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23303/60A Expired GB883329A (en) 1959-07-07 1960-07-04 Process for the production of alkaloid derivatives of lyserqic acid

Country Status (1)

Country Link
GB (1) GB883329A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1219173B (en) * 1962-08-30 1966-06-16 Sandoz Ag Process for the production of lysergic acid derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1219173B (en) * 1962-08-30 1966-06-16 Sandoz Ag Process for the production of lysergic acid derivatives

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