GB1111010A - Process for the production of the antibiotic pleuromutilin - Google Patents
Process for the production of the antibiotic pleuromutilinInfo
- Publication number
- GB1111010A GB1111010A GB56203/67A GB5620367A GB1111010A GB 1111010 A GB1111010 A GB 1111010A GB 56203/67 A GB56203/67 A GB 56203/67A GB 5620367 A GB5620367 A GB 5620367A GB 1111010 A GB1111010 A GB 1111010A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pleuromutilin
- antibiotic
- fermentation broth
- feed
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZRZNJUXESFHSIO-UHFFFAOYSA-N Pleuromutilin Natural products CC1C(O)C(C)(C=C)CC(OC(=O)CO)C2(C)C(C)CCC31C2C(=O)CC3 ZRZNJUXESFHSIO-UHFFFAOYSA-N 0.000 title abstract 5
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- ZRZNJUXESFHSIO-VYTKZBNOSA-N pleuromutilin Chemical compound C([C@H]([C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CO)C)C[C@]32[C@H]1C(=O)CC3 ZRZNJUXESFHSIO-VYTKZBNOSA-N 0.000 title 1
- ZRZNJUXESFHSIO-BKUNHTPHSA-N 3de4a80mz1 Chemical compound C([C@H]([C@@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CO)C)C[C@]32[C@H]1C(=O)CC3 ZRZNJUXESFHSIO-BKUNHTPHSA-N 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000006052 feed supplement Substances 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241001572230 Clitopilus passeckerianus Species 0.000 abstract 1
- 241000228143 Penicillium Species 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Fodder In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Feed For Specific Animals (AREA)
Abstract
The antibiotic BC 757, also known as pleuromutilin, is prepared by cultivating Clitopilus passeckerianus (Pil.) Sing. NRRL 3100, or a pleuromutilin-producing mutant or variant thereof, in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen. The antibiotic may be isolated by conventional methods for the isolation of pleuromutilin from a fermentation broth. Pleuromutilin is a growth stimulant and may be added to animal feeds to form a feed supplement or a ready-mixed feed. For this purpose, the dried fermentation broth may be used. Conventional feed supplements containing penicillium mycelia may be used.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT340364A AT250770B (en) | 1964-04-17 | 1964-04-17 | Feed |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1111010A true GB1111010A (en) | 1968-04-24 |
Family
ID=3549996
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB16059/65A Expired GB1111009A (en) | 1964-04-17 | 1965-04-14 | Pleuromutilin derivatives useful in animal feed stuffs |
| GB56203/67A Expired GB1111010A (en) | 1964-04-17 | 1965-04-14 | Process for the production of the antibiotic pleuromutilin |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB16059/65A Expired GB1111009A (en) | 1964-04-17 | 1965-04-14 | Pleuromutilin derivatives useful in animal feed stuffs |
Country Status (9)
| Country | Link |
|---|---|
| JP (2) | JPS4916631B1 (en) |
| AT (1) | AT250770B (en) |
| DE (1) | DE1249657B (en) |
| DK (2) | DK135973B (en) |
| ES (1) | ES311866A1 (en) |
| GB (2) | GB1111009A (en) |
| IL (2) | IL23314A (en) |
| NL (3) | NL6504695A (en) |
| SE (3) | SE362417B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4041175A (en) | 1974-05-13 | 1977-08-09 | E. R. Squibb & Sons, Inc. | Use of pleuromutilin for the treatment of swine dysentery |
| BG64840B1 (en) * | 2001-04-09 | 2006-06-30 | "Балканфарма-Разград" АД | Method for pleuromutiline preparation |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3949079A (en) * | 1964-04-17 | 1976-04-06 | Biochemie Ges.M.B.H. | Antibiotic derivatives |
| US4129721A (en) * | 1977-12-08 | 1978-12-12 | Eli Lilly And Company | A-40104 antibiotics and process for production thereof |
| JPS55113645U (en) * | 1979-01-31 | 1980-08-11 | ||
| US11168049B1 (en) * | 2020-12-19 | 2021-11-09 | Xi'an Taikomed Pharmaceutical Technology Co., Ltd. | Pleuromulin tretinoin ester with antibacterial activity and a method of preparing the same |
-
0
- DE DENDAT1249657D patent/DE1249657B/de active Pending
-
1964
- 1964-04-17 AT AT340364A patent/AT250770B/en active
-
1965
- 1965-04-07 IL IL23314A patent/IL23314A/en unknown
- 1965-04-07 IL IL31374A patent/IL31374A/en unknown
- 1965-04-09 SE SE10225/69A patent/SE362417B/xx unknown
- 1965-04-09 SE SE4674/65A patent/SE322405B/xx unknown
- 1965-04-09 SE SE10224/69A patent/SE354482B/xx unknown
- 1965-04-12 DK DK184965AA patent/DK135973B/en unknown
- 1965-04-13 NL NL6504695A patent/NL6504695A/xx unknown
- 1965-04-14 GB GB16059/65A patent/GB1111009A/en not_active Expired
- 1965-04-14 ES ES0311866A patent/ES311866A1/en not_active Expired
- 1965-04-14 GB GB56203/67A patent/GB1111010A/en not_active Expired
-
1967
- 1967-10-31 JP JP42070208A patent/JPS4916631B1/ja active Pending
-
1969
- 1969-07-18 NL NL6911083A patent/NL6911083A/xx unknown
- 1969-07-18 NL NL6911082A patent/NL6911082A/xx unknown
-
1971
- 1971-08-13 DK DK396671AA patent/DK127192B/en unknown
- 1971-12-03 JP JP46098209A patent/JPS5026540B1/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4041175A (en) | 1974-05-13 | 1977-08-09 | E. R. Squibb & Sons, Inc. | Use of pleuromutilin for the treatment of swine dysentery |
| BG64840B1 (en) * | 2001-04-09 | 2006-06-30 | "Балканфарма-Разград" АД | Method for pleuromutiline preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| DK135973B (en) | 1977-07-25 |
| IL23314A (en) | 1969-04-30 |
| JPS4916631B1 (en) | 1974-04-23 |
| SE322405B (en) | 1970-04-06 |
| DK127192B (en) | 1973-10-01 |
| GB1111009A (en) | 1968-04-24 |
| AT250770B (en) | 1966-11-25 |
| NL6504695A (en) | 1965-10-18 |
| ES311866A1 (en) | 1965-07-16 |
| NL6911082A (en) | 1969-10-27 |
| SE354482B (en) | 1973-03-12 |
| DK135973C (en) | 1977-12-27 |
| JPS5026540B1 (en) | 1975-09-01 |
| DE1249657B (en) | |
| IL31374A (en) | 1969-05-28 |
| NL6911083A (en) | 1969-10-27 |
| SE362417B (en) | 1973-12-10 |
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