GB1111009A - Pleuromutilin derivatives useful in animal feed stuffs - Google Patents

Pleuromutilin derivatives useful in animal feed stuffs

Info

Publication number
GB1111009A
GB1111009A GB16059/65A GB1605965A GB1111009A GB 1111009 A GB1111009 A GB 1111009A GB 16059/65 A GB16059/65 A GB 16059/65A GB 1605965 A GB1605965 A GB 1605965A GB 1111009 A GB1111009 A GB 1111009A
Authority
GB
United Kingdom
Prior art keywords
pleuromutilin
acid
ester
hydrogenation product
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB16059/65A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz GmbH
Original Assignee
Biochemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie GmbH filed Critical Biochemie GmbH
Publication of GB1111009A publication Critical patent/GB1111009A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics

Abstract

Esters of the antibiotic pleuromutilin or its hydrogenation product are obtained by reacting pleuromutilin or its hydrogenation product with an ester-forming derivative of an acid selected from isocyanic acid, an aliphatic monocarboxylic acid having from 3 to 19 carbon atoms, a haloformic acid or monohaloacetic acid, an aliphatic dicarboxylic acid having from 3 to 14 carbon atoms, or a sulphonic acid. The acid may contain an additional group capable of reacting with a base to form a salt; in which case, the first-formed ester is reacted with a base to form the salt. The ester of the hydrogenation product of pleuromutilin may be produced by forming the ester of pleuromutilin and hydrogenating the ester before or after treatment with the base to form the salt. Pleuromutilin has the formula <FORM:1111009/C2/1> On hydrogenation the vinyl group of pleuromutilin is hydrogenated to an ethyl group. Pleuromutilin, originally named antibiotic BC 757, was produced by the cultivation of Clitopilus passeckerianus (Pil.) Sing. NRRL 3100 in accordance with Specification 1,111,010. Typical esters are the succinate, monopalmitate, a - carboxyethylcarbamate, 1,3 - dicarboxypropylcarbamate, beta - sulphopropionate and m-sulphobenzoate. An animal feed or feed supplement comprises one or more esters of pleuromutilin or its hydrogenation product. Conventional feed supplements containing penicillium mycelia may be used.
GB16059/65A 1964-04-17 1965-04-14 Pleuromutilin derivatives useful in animal feed stuffs Expired GB1111009A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT340364A AT250770B (en) 1964-04-17 1964-04-17 Feed

Publications (1)

Publication Number Publication Date
GB1111009A true GB1111009A (en) 1968-04-24

Family

ID=3549996

Family Applications (2)

Application Number Title Priority Date Filing Date
GB16059/65A Expired GB1111009A (en) 1964-04-17 1965-04-14 Pleuromutilin derivatives useful in animal feed stuffs
GB56203/67A Expired GB1111010A (en) 1964-04-17 1965-04-14 Process for the production of the antibiotic pleuromutilin

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB56203/67A Expired GB1111010A (en) 1964-04-17 1965-04-14 Process for the production of the antibiotic pleuromutilin

Country Status (9)

Country Link
JP (2) JPS4916631B1 (en)
AT (1) AT250770B (en)
DE (1) DE1249657B (en)
DK (2) DK135973B (en)
ES (1) ES311866A1 (en)
GB (2) GB1111009A (en)
IL (2) IL23314A (en)
NL (3) NL6504695A (en)
SE (3) SE354482B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002589A1 (en) * 1977-12-08 1979-06-27 Eli Lilly And Company A-40104 antibiotics, their preparation, and formulations containing them
US11168049B1 (en) * 2020-12-19 2021-11-09 Xi'an Taikomed Pharmaceutical Technology Co., Ltd. Pleuromulin tretinoin ester with antibacterial activity and a method of preparing the same

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949079A (en) * 1964-04-17 1976-04-06 Biochemie Ges.M.B.H. Antibiotic derivatives
US4041175A (en) 1974-05-13 1977-08-09 E. R. Squibb & Sons, Inc. Use of pleuromutilin for the treatment of swine dysentery
JPS55113645U (en) * 1979-01-31 1980-08-11
BG64840B1 (en) * 2001-04-09 2006-06-30 "Балканфарма-Разград" АД Method for pleuromutiline preparation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002589A1 (en) * 1977-12-08 1979-06-27 Eli Lilly And Company A-40104 antibiotics, their preparation, and formulations containing them
FR2411204A1 (en) * 1977-12-08 1979-07-06 Lilly Co Eli NEW ANTIBIOTICS AND THEIR PRODUCTION PROCESS
US11168049B1 (en) * 2020-12-19 2021-11-09 Xi'an Taikomed Pharmaceutical Technology Co., Ltd. Pleuromulin tretinoin ester with antibacterial activity and a method of preparing the same

Also Published As

Publication number Publication date
IL31374A (en) 1969-05-28
GB1111010A (en) 1968-04-24
NL6504695A (en) 1965-10-18
NL6911083A (en) 1969-10-27
AT250770B (en) 1966-11-25
JPS5026540B1 (en) 1975-09-01
DK135973C (en) 1977-12-27
SE322405B (en) 1970-04-06
DE1249657B (en)
SE354482B (en) 1973-03-12
SE362417B (en) 1973-12-10
JPS4916631B1 (en) 1974-04-23
IL23314A (en) 1969-04-30
DK127192B (en) 1973-10-01
ES311866A1 (en) 1965-07-16
NL6911082A (en) 1969-10-27
DK135973B (en) 1977-07-25

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