GB999794A - Improvements in or relating to the production of an antibiotic containing a cyclopentanophenanthrene nucleus and salts thereof - Google Patents
Improvements in or relating to the production of an antibiotic containing a cyclopentanophenanthrene nucleus and salts thereofInfo
- Publication number
- GB999794A GB999794A GB2810961A GB2810961A GB999794A GB 999794 A GB999794 A GB 999794A GB 2810961 A GB2810961 A GB 2810961A GB 2810961 A GB2810961 A GB 2810961A GB 999794 A GB999794 A GB 999794A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antibiotic
- fungus
- solution
- leo
- mutant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Fusidic acid which is an antibiotic designated ZN-6 and contains a steroid nucleus is prepared by growing a mutant of the fungus Fusidium coccineum Fuck K. Tubuki capable of forming the said antibiotic under aerobic conditions in an aqueous nutrient solution containing sources of carbon and nitrogen and inorganic salts, the fermentation being continued until a substantial antibiotic activity has been imparted to said solution and recovering the antibiotic therefrom. The mutant of the fungus may be obtained by irradiating a spore suspension with ionizing or non-ionizing rays or the spores may be exposed to the action of mutagenic chemicals such as diethyl sulphute or mustard gas. The antibiotic may be isolated from the solution by filtering, and either adding an adsorbing agent to the filtered solution and eluting the antibiotic therefrom, or adding an amine or an amine salt to convert the antibiotic into a form soluble in an organic solvent which is substantially water immiscible. Alternatively an acid may be added to the filtered broth to ensure that the antibiotic is present as the sparingly water-soluble free acid. Specific mutants of the above fungus are designated Leo-U42, Leo-U79 and Fc-U 404 and are deposited at the Commonwealth Mycological Institute. Specification 930,786 is referred to.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2810961A GB999794A (en) | 1961-08-02 | 1961-08-02 | Improvements in or relating to the production of an antibiotic containing a cyclopentanophenanthrene nucleus and salts thereof |
DK336862A DK107349C (en) | 1961-08-02 | 1962-07-30 | Process for the preparation of an antibiotic substance, fusidic acid, or salts thereof. |
SE836962A SE306711B (en) | 1961-08-02 | 1962-07-30 | |
CH911662A CH488011A (en) | 1960-09-21 | 1962-07-30 | Process for the production of the antibiotic fusidic acid and its salts |
DEL42612A DE1203423B (en) | 1961-08-02 | 1962-08-02 | Process for the preparation of the antibiotic ZN-6 (fusidic acid) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2810961A GB999794A (en) | 1961-08-02 | 1961-08-02 | Improvements in or relating to the production of an antibiotic containing a cyclopentanophenanthrene nucleus and salts thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
GB999794A true GB999794A (en) | 1965-07-28 |
Family
ID=10270414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2810961A Expired GB999794A (en) | 1960-09-21 | 1961-08-02 | Improvements in or relating to the production of an antibiotic containing a cyclopentanophenanthrene nucleus and salts thereof |
Country Status (4)
Country | Link |
---|---|
DE (1) | DE1203423B (en) |
DK (1) | DK107349C (en) |
GB (1) | GB999794A (en) |
SE (1) | SE306711B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2204331A1 (en) * | 2002-10-09 | 2004-04-16 | Ercros Industrial, S.A. | Obtaining fusidic acid from fermentation source comprises joint separation of bio-mss and of fusidic acid produced by insolubilization in acid medium followed by extraction with organic dissolvent-immiscible with water |
CN101792476A (en) * | 2010-03-12 | 2010-08-04 | 江苏九阳生物科技有限公司 | Method for extracting and separating fusidic acid |
US8933063B2 (en) | 2005-10-31 | 2015-01-13 | Leo Pharma A/S | Preparation of a crystalline antibiotic substance |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101812498A (en) * | 2010-04-20 | 2010-08-25 | 江苏九阳生物科技有限公司 | Fermentation production method of fusidic acid |
-
1961
- 1961-08-02 GB GB2810961A patent/GB999794A/en not_active Expired
-
1962
- 1962-07-30 DK DK336862A patent/DK107349C/en active
- 1962-07-30 SE SE836962A patent/SE306711B/xx unknown
- 1962-08-02 DE DEL42612A patent/DE1203423B/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2204331A1 (en) * | 2002-10-09 | 2004-04-16 | Ercros Industrial, S.A. | Obtaining fusidic acid from fermentation source comprises joint separation of bio-mss and of fusidic acid produced by insolubilization in acid medium followed by extraction with organic dissolvent-immiscible with water |
US8933063B2 (en) | 2005-10-31 | 2015-01-13 | Leo Pharma A/S | Preparation of a crystalline antibiotic substance |
CN101792476A (en) * | 2010-03-12 | 2010-08-04 | 江苏九阳生物科技有限公司 | Method for extracting and separating fusidic acid |
CN101792476B (en) * | 2010-03-12 | 2015-04-08 | 江苏九阳生物制药有限公司 | Method for extracting and separating fusidic acid |
Also Published As
Publication number | Publication date |
---|---|
DK107349C (en) | 1967-05-22 |
SE306711B (en) | 1968-12-09 |
DE1203423B (en) | 1965-10-21 |
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