GB999794A - Improvements in or relating to the production of an antibiotic containing a cyclopentanophenanthrene nucleus and salts thereof - Google Patents

Improvements in or relating to the production of an antibiotic containing a cyclopentanophenanthrene nucleus and salts thereof

Info

Publication number
GB999794A
GB999794A GB2810961A GB2810961A GB999794A GB 999794 A GB999794 A GB 999794A GB 2810961 A GB2810961 A GB 2810961A GB 2810961 A GB2810961 A GB 2810961A GB 999794 A GB999794 A GB 999794A
Authority
GB
United Kingdom
Prior art keywords
antibiotic
fungus
solution
leo
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2810961A
Inventor
Inger Kirk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KNUD ABILDGAARD
Original Assignee
KNUD ABILDGAARD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KNUD ABILDGAARD filed Critical KNUD ABILDGAARD
Priority to GB2810961A priority Critical patent/GB999794A/en
Priority to SE836962A priority patent/SE306711B/xx
Priority to CH911662A priority patent/CH488011A/en
Priority to DK336862A priority patent/DK107349C/en
Priority to DEL42612A priority patent/DE1203423B/en
Publication of GB999794A publication Critical patent/GB999794A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Fusidic acid which is an antibiotic designated ZN-6 and contains a steroid nucleus is prepared by growing a mutant of the fungus Fusidium coccineum Fuck K. Tubuki capable of forming the said antibiotic under aerobic conditions in an aqueous nutrient solution containing sources of carbon and nitrogen and inorganic salts, the fermentation being continued until a substantial antibiotic activity has been imparted to said solution and recovering the antibiotic therefrom. The mutant of the fungus may be obtained by irradiating a spore suspension with ionizing or non-ionizing rays or the spores may be exposed to the action of mutagenic chemicals such as diethyl sulphute or mustard gas. The antibiotic may be isolated from the solution by filtering, and either adding an adsorbing agent to the filtered solution and eluting the antibiotic therefrom, or adding an amine or an amine salt to convert the antibiotic into a form soluble in an organic solvent which is substantially water immiscible. Alternatively an acid may be added to the filtered broth to ensure that the antibiotic is present as the sparingly water-soluble free acid. Specific mutants of the above fungus are designated Leo-U42, Leo-U79 and Fc-U 404 and are deposited at the Commonwealth Mycological Institute. Specification 930,786 is referred to.
GB2810961A 1960-09-21 1961-08-02 Improvements in or relating to the production of an antibiotic containing a cyclopentanophenanthrene nucleus and salts thereof Expired GB999794A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB2810961A GB999794A (en) 1961-08-02 1961-08-02 Improvements in or relating to the production of an antibiotic containing a cyclopentanophenanthrene nucleus and salts thereof
SE836962A SE306711B (en) 1961-08-02 1962-07-30
CH911662A CH488011A (en) 1960-09-21 1962-07-30 Process for the production of the antibiotic fusidic acid and its salts
DK336862A DK107349C (en) 1961-08-02 1962-07-30 Process for the preparation of an antibiotic substance, fusidic acid, or salts thereof.
DEL42612A DE1203423B (en) 1961-08-02 1962-08-02 Process for the preparation of the antibiotic ZN-6 (fusidic acid)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2810961A GB999794A (en) 1961-08-02 1961-08-02 Improvements in or relating to the production of an antibiotic containing a cyclopentanophenanthrene nucleus and salts thereof

Publications (1)

Publication Number Publication Date
GB999794A true GB999794A (en) 1965-07-28

Family

ID=10270414

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2810961A Expired GB999794A (en) 1960-09-21 1961-08-02 Improvements in or relating to the production of an antibiotic containing a cyclopentanophenanthrene nucleus and salts thereof

Country Status (4)

Country Link
DE (1) DE1203423B (en)
DK (1) DK107349C (en)
GB (1) GB999794A (en)
SE (1) SE306711B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2204331A1 (en) * 2002-10-09 2004-04-16 Ercros Industrial, S.A. Obtaining fusidic acid from fermentation source comprises joint separation of bio-mss and of fusidic acid produced by insolubilization in acid medium followed by extraction with organic dissolvent-immiscible with water
CN101792476A (en) * 2010-03-12 2010-08-04 江苏九阳生物科技有限公司 Method for extracting and separating fusidic acid
US8933063B2 (en) 2005-10-31 2015-01-13 Leo Pharma A/S Preparation of a crystalline antibiotic substance

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101812498A (en) * 2010-04-20 2010-08-25 江苏九阳生物科技有限公司 Fermentation production method of fusidic acid

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2204331A1 (en) * 2002-10-09 2004-04-16 Ercros Industrial, S.A. Obtaining fusidic acid from fermentation source comprises joint separation of bio-mss and of fusidic acid produced by insolubilization in acid medium followed by extraction with organic dissolvent-immiscible with water
US8933063B2 (en) 2005-10-31 2015-01-13 Leo Pharma A/S Preparation of a crystalline antibiotic substance
CN101792476A (en) * 2010-03-12 2010-08-04 江苏九阳生物科技有限公司 Method for extracting and separating fusidic acid
CN101792476B (en) * 2010-03-12 2015-04-08 江苏九阳生物制药有限公司 Method for extracting and separating fusidic acid

Also Published As

Publication number Publication date
SE306711B (en) 1968-12-09
DE1203423B (en) 1965-10-21
DK107349C (en) 1967-05-22

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