GB945637A - Process for the production of ª -aminobenzyl penicillin - Google Patents
Process for the production of ª -aminobenzyl penicillinInfo
- Publication number
- GB945637A GB945637A GB3567262A GB3567262A GB945637A GB 945637 A GB945637 A GB 945637A GB 3567262 A GB3567262 A GB 3567262A GB 3567262 A GB3567262 A GB 3567262A GB 945637 A GB945637 A GB 945637A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- bacteria
- aminopenicillanic acid
- bacterial cells
- splitting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
- C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
a -Aminobenzyl penicillin is produced by cultivating in a nutrient medium under aerobic conditions at an approximately neutral pH, a culture of penicillin-splitting bacteria, separating the bacterial cells from the culture solution and suspending them in an aqueous medium, adding thereto 6-aminopenicillanic acid and a -phenylglycylamide or a -phenyl-glycine ethyl ester, the bacterial cells functioning to link the 6-amino group of the 6-aminopenicillanic acid with the a -aminophenyl-acetyl radical, adjusting the pH to between 4.5 and 8 and incubating the resulting reaction mixture for at least one hour, the penicillin-splitting bacteria being selected from bacteria capable of preferentially attacking the amide bond in the 6-position of a penicillin molecule with the formation of 6-aminopenicillanic acid as evidenced by the ability of the bacteria to inactivate penicillin G by at least 20% within 24 hours to yield a solution in which the inactivated penicillin G can be at least partially reactivated by the addition of phenylacetyl chloride thereto. Examples describe the process utilizing Escherichia coli ATCC 11,105.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEF0035078 | 1961-10-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB945637A true GB945637A (en) | 1964-01-02 |
Family
ID=7095841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3567262A Expired GB945637A (en) | 1961-10-07 | 1962-09-19 | Process for the production of ª -aminobenzyl penicillin |
Country Status (4)
Country | Link |
---|---|
AT (1) | AT243986B (en) |
DK (1) | DK131428B (en) |
GB (1) | GB945637A (en) |
SE (1) | SE362078B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2070135A1 (en) * | 1969-10-16 | 1971-09-10 | Kyowa Hakko Kogyo Kk |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5343597B1 (en) * | 1970-12-25 | 1978-11-21 | ||
JPS5548797B1 (en) * | 1971-04-02 | 1980-12-08 |
-
1962
- 1962-09-12 AT AT727962A patent/AT243986B/en active
- 1962-09-19 DK DK407462A patent/DK131428B/en unknown
- 1962-09-19 GB GB3567262A patent/GB945637A/en not_active Expired
- 1962-10-05 SE SE1070562A patent/SE362078B/xx unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2070135A1 (en) * | 1969-10-16 | 1971-09-10 | Kyowa Hakko Kogyo Kk |
Also Published As
Publication number | Publication date |
---|---|
AT243986B (en) | 1965-12-10 |
SE362078B (en) | 1973-11-26 |
DK131428C (en) | 1975-12-01 |
DK131428B (en) | 1975-07-14 |
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