SI0977883T2 - Izboljšan postopek za fermentativno pripravo penicilina - Google Patents

Izboljšan postopek za fermentativno pripravo penicilina

Info

Publication number
SI0977883T2
SI0977883T2 SI9830717T SI9830717T SI0977883T2 SI 0977883 T2 SI0977883 T2 SI 0977883T2 SI 9830717 T SI9830717 T SI 9830717T SI 9830717 T SI9830717 T SI 9830717T SI 0977883 T2 SI0977883 T2 SI 0977883T2
Authority
SI
Slovenia
Prior art keywords
apa
penicillin
improved process
extraction
organic solvent
Prior art date
Application number
SI9830717T
Other languages
English (en)
Other versions
SI0977883T1 (sl
Inventor
Pieter Theodorus Kerkhof
Rienk Hendrik Kuipers
Hubertus Gerardus Mar Walraven
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8228240&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI0977883(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of SI0977883T1 publication Critical patent/SI0977883T1/sl
Publication of SI0977883T2 publication Critical patent/SI0977883T2/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position
SI9830717T 1997-04-22 1998-04-22 Izboljšan postopek za fermentativno pripravo penicilina SI0977883T2 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97201200 1997-04-22
PCT/EP1998/002462 WO1998048039A1 (en) 1997-04-22 1998-04-22 Improved process for the fermentative production of penicillin
EP98921489A EP0977883B2 (en) 1997-04-22 1998-04-22 Improved process for the fermentative production of penicillin

Publications (2)

Publication Number Publication Date
SI0977883T1 SI0977883T1 (sl) 2005-02-28
SI0977883T2 true SI0977883T2 (sl) 2007-12-31

Family

ID=8228240

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9830717T SI0977883T2 (sl) 1997-04-22 1998-04-22 Izboljšan postopek za fermentativno pripravo penicilina

Country Status (16)

Country Link
US (1) US20020058302A1 (sl)
EP (2) EP1475444A1 (sl)
JP (1) JP2001521396A (sl)
KR (1) KR20010012081A (sl)
CN (1) CN1187454C (sl)
AT (1) ATE278800T1 (sl)
AU (1) AU7432198A (sl)
BR (1) BR9808941A (sl)
DE (2) DE69826852T8 (sl)
ES (1) ES2224392T5 (sl)
ID (1) ID25658A (sl)
PL (1) PL336385A1 (sl)
PT (1) PT977883E (sl)
RU (1) RU2223323C2 (sl)
SI (1) SI0977883T2 (sl)
WO (1) WO1998048039A1 (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03001712A (es) * 2000-08-28 2004-09-10 Dsm Nv Proceso para la preparacion de un nucleo de beta-lactama y aplicacion del mismo.
JP2002316991A (ja) * 2001-04-18 2002-10-31 Otsuka Chem Co Ltd ペニシリン及びセファロスポリン化合物
EA017121B1 (ru) * 2005-12-02 2012-10-30 Дсм Синокем Фармасьютикалз Нидерландз Б.В. Способ получения калиевой соли пенициллина g
CN101321771B (zh) * 2005-12-02 2012-05-30 中化帝斯曼制药有限公司荷兰公司 青霉素钾盐的制备工艺
WO2014072843A1 (en) * 2012-11-07 2014-05-15 Vardhman Chemtech Limited Process for preparing isoxazolyl penicillins
CN102925526B (zh) * 2012-11-23 2014-10-15 华北制药河北华民药业有限责任公司 一种6-氨基青霉烷酸的制备方法
CN103695447B (zh) * 2013-11-11 2015-10-14 华北制药河北华民药业有限责任公司 一种新型内酰胺类抗生素合成酶及其编码基因和应用
CN104099396B (zh) * 2014-07-22 2016-03-23 石药集团中诺药业（石家庄）有限公司 一种直通法制备阿莫西林的工艺
CN104357504A (zh) * 2014-10-30 2015-02-18 青岛科技大学 一种细胞催化生产手性甲氧基吡啶乙醇
CN105732663B (zh) * 2016-03-28 2018-03-16 西藏百年汉克药业有限公司 6‑氨基青霉烷酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1299883A (fr) * 1961-09-06 1962-07-27 Pfizer & Co C Perfectionnements apportés aux procédés pour séparer des amino-acides amphotères de leurs solutions aqueuses
FR2188607A5 (en) * 1972-06-12 1974-01-18 Aries Robert 6-Aminopenicillanic acid prodn - by treatment of benzylpenicillin with amido-hydrolase 3-5-2
JPS57501610A (sl) * 1980-10-23 1982-09-09
NL8301373A (nl) * 1983-04-19 1984-11-16 Tno Geimmobiliseerde biokatalysatoren.
DE3729338A1 (de) * 1987-09-02 1989-03-23 Biotechnolog Forschung Gmbh Verfahren zur abtrennung von penicillin g aus einem fermentationsmedium durch extraktion
DE4005366A1 (de) * 1990-02-21 1991-08-22 Schott Glaswerke Extraktionsverfahren mit zwei nicht oder nur begrenzt miteinander mischbaren fluessigen phasen
ES2105989B1 (es) * 1996-03-15 1998-07-01 Antibioticos Sa Procedimiento alternativo para la obtencion del acido 6-amino penicilanico (6-apa).

Also Published As

Publication number Publication date
CN1187454C (zh) 2005-02-02
DE69826852T2 (de) 2005-11-17
CN1253594A (zh) 2000-05-17
EP0977883B2 (en) 2007-08-01
EP0977883A1 (en) 2000-02-09
PL336385A1 (en) 2000-06-19
EP1475444A1 (en) 2004-11-10
KR20010012081A (ko) 2001-02-15
AU7432198A (en) 1998-11-13
ATE278800T1 (de) 2004-10-15
BR9808941A (pt) 2000-08-01
ES2224392T5 (es) 2008-03-01
SI0977883T1 (sl) 2005-02-28
ES2224392T3 (es) 2005-03-01
PT977883E (pt) 2005-01-31
WO1998048039A1 (en) 1998-10-29
JP2001521396A (ja) 2001-11-06
RU2223323C2 (ru) 2004-02-10
DE69826852T3 (de) 2008-02-14
EP0977883B1 (en) 2004-10-06
US20020058302A1 (en) 2002-05-16
ID25658A (id) 2000-10-19
DE69826852T8 (de) 2008-10-30
DE69826852D1 (de) 2004-11-11

Similar Documents

Publication Publication Date Title
YU63602A (sh) Postupak za prečišćavanje fermentacionog bujona
SI0977883T2 (sl) Izboljšan postopek za fermentativno pripravo penicilina
YU39102A (sh) Postupak dobijanja statina iz fermentacione smeše
Fuganti et al. Immobilized benzylpenicillin acylase: application to the synthesis of optically active forms of carnitin and propranalol
UA48944C2 (uk) Спосіб одержання солі клавуланової кислоти
RU99124595A (ru) Улучшенный способ ферментативного производства пенициллина
AU2922395A (en) Recovery of carboxylic acid from organic solution that contains an amine and an extraction enhancer
WO2000020620A8 (en) Process for recovering carboxylic acides from a fermentation broth
ES2105989A1 (es) Procedimiento alternativo para la obtencion del acido 6-amino penicilanico (6-apa).
ATE269906T1 (de) Verbesserungen bezogen auf die herstellung von lactamverbindungen
PL330706A1 (en) Improved method of obtaining cephalosporin by fermentation process
EP1229031A4 (en) PROCESS FOR THE PREPARATION OF 3,4-METHYLENEDIOXYMANDELIC ACID
ZA200004801B (en) Process for the fermentative production of cephalosporin.
WO1999012958A3 (de) Ampullosporin, verfahren zu dessen herstellung und dessen verwendung
Keri et al. Method of purifying statins from a fermentation broth
AU7677798A (en) Process for the preparation of ampicillin
Zhou et al. Study on fermentation process of pellet from Penicillium chrysogenum. V. Trial to improve the conversion yield of penicillin.
JPS5272886A (en) Preparation of cephalosporin compound
GB883329A (en) Process for the production of alkaloid derivatives of lyserqic acid
JPS55135597A (en) Preparation of amoxicillin
GEP19991831B (en) Method for Obtaining 2,2,6,6-tetramethylpiperidine