DK0741732T3 - Fremgangsmåde til dannelse af et clavulansyresalt - Google Patents

Fremgangsmåde til dannelse af et clavulansyresalt

Info

Publication number
DK0741732T3
DK0741732T3 DK95907075T DK95907075T DK0741732T3 DK 0741732 T3 DK0741732 T3 DK 0741732T3 DK 95907075 T DK95907075 T DK 95907075T DK 95907075 T DK95907075 T DK 95907075T DK 0741732 T3 DK0741732 T3 DK 0741732T3
Authority
DK
Denmark
Prior art keywords
forming
acid salt
clavulanic acid
clavulanic
salt
Prior art date
Application number
DK95907075T
Other languages
Danish (da)
English (en)
Inventor
Michael Alan Cook
Geoffrey Clive Webb
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of DK0741732T3 publication Critical patent/DK0741732T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D503/00Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
DK95907075T 1994-02-02 1995-01-31 Fremgangsmåde til dannelse af et clavulansyresalt DK0741732T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9401969A GB9401969D0 (en) 1994-02-02 1994-02-02 Process
PCT/GB1995/000191 WO1995021173A1 (en) 1994-02-02 1995-01-31 Process for the preparation of a salt of clavulanic acid

Publications (1)

Publication Number Publication Date
DK0741732T3 true DK0741732T3 (da) 2001-10-15

Family

ID=10749727

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95907075T DK0741732T3 (da) 1994-02-02 1995-01-31 Fremgangsmåde til dannelse af et clavulansyresalt

Country Status (32)

Country Link
US (1) US5965728A (bg)
EP (1) EP0741732B1 (bg)
JP (1) JP4074336B2 (bg)
KR (1) KR100388769B1 (bg)
CN (1) CN1065246C (bg)
AP (1) AP610A (bg)
AT (1) ATE202358T1 (bg)
AU (1) AU688849B2 (bg)
BG (1) BG63307B1 (bg)
BR (1) BR9506919A (bg)
CA (1) CA2182504C (bg)
CZ (1) CZ294005B6 (bg)
DE (1) DE69521415T2 (bg)
DK (1) DK0741732T3 (bg)
ES (1) ES2159626T3 (bg)
FI (1) FI111949B (bg)
GB (1) GB9401969D0 (bg)
GR (1) GR3036602T3 (bg)
HK (1) HK1012373A1 (bg)
HU (1) HU226597B1 (bg)
MX (1) MX9603204A (bg)
NO (1) NO314505B1 (bg)
NZ (1) NZ278927A (bg)
OA (1) OA10587A (bg)
PL (1) PL181451B1 (bg)
PT (1) PT741732E (bg)
RO (1) RO115730B1 (bg)
RU (1) RU2140418C1 (bg)
SI (1) SI0741732T1 (bg)
SK (1) SK282544B6 (bg)
UA (1) UA48944C2 (bg)
WO (1) WO1995021173A1 (bg)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
EP0867515B1 (en) * 1997-03-24 1999-12-08 CIPAN-Companhia Industrial Produtora De Antibioticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DZ2456A1 (fr) 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
DK1412078T3 (da) 2001-08-02 2009-02-02 Lg Life Sciences Ltd Fremgangsmåde til fremstilling af amino-beskyttede derivater af 4-aminomethylen-pyrrolidin-3-on, Gemifloxacin eller salte deraf
CN109715156A (zh) 2016-07-14 2019-05-03 尔察祯有限公司 用于治疗细菌感染的头孢布烯和克拉维酸的组合
CN108822134B (zh) * 2018-04-25 2021-06-25 国药集团威奇达药业有限公司 克拉维酸叔丁胺盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB8404749D0 (en) * 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor

Also Published As

Publication number Publication date
CA2182504C (en) 2008-04-08
JP4074336B2 (ja) 2008-04-09
ATE202358T1 (de) 2001-07-15
US5965728A (en) 1999-10-12
NZ278927A (en) 1998-02-26
RU2140418C1 (ru) 1999-10-27
NO963217L (no) 1996-10-01
OA10587A (en) 2002-07-10
SK100396A3 (en) 1996-12-04
NO963217D0 (no) 1996-08-01
WO1995021173A1 (en) 1995-08-10
CZ294005B6 (cs) 2004-09-15
AP9600838A0 (en) 1996-07-31
HUT74885A (en) 1997-02-28
HU226597B1 (en) 2009-04-28
RO115730B1 (ro) 2000-05-30
AU1541295A (en) 1995-08-21
HK1012373A1 (en) 1999-07-30
FI111949B (fi) 2003-10-15
UA48944C2 (uk) 2002-09-16
MX9603204A (es) 1997-03-29
FI963050A (fi) 1996-10-01
PT741732E (pt) 2001-11-30
PL315782A1 (en) 1996-12-09
BG100765A (bg) 1997-09-30
GB9401969D0 (en) 1994-03-30
GR3036602T3 (en) 2001-12-31
CZ229496A3 (en) 1997-01-15
HU9602128D0 (en) 1996-09-30
KR100388769B1 (ko) 2003-09-02
DE69521415T2 (de) 2002-05-29
EP0741732A1 (en) 1996-11-13
JPH09508411A (ja) 1997-08-26
AP610A (en) 1997-09-04
CN1065246C (zh) 2001-05-02
AU688849B2 (en) 1998-03-19
ES2159626T3 (es) 2001-10-16
BR9506919A (pt) 1997-09-30
DE69521415D1 (de) 2001-07-26
PL181451B1 (en) 2001-07-31
FI963050A0 (fi) 1996-08-01
SI0741732T1 (bg) 2001-10-31
EP0741732B1 (en) 2001-06-20
CA2182504A1 (en) 1995-08-10
BG63307B1 (bg) 2001-09-28
CN1144528A (zh) 1997-03-05
NO314505B1 (no) 2003-03-31
SK282544B6 (sk) 2002-10-08

Similar Documents

Publication Publication Date Title
DK0845956T4 (da) Fremgangsmåde til fremstilling af en tandbörste
DK0650006T3 (da) Fremgangsmåde til foring af et siderør
FI922938A (fi) Menetelmä kanavanvaihdon tehostamiseksi
FI940487A0 (fi) Vianmääritysmenetelmä kehitysprosessia varten
DK1306318T3 (da) Fremgangsmåde til fremstilling af en kassettedispenser
FI943938A0 (fi) Menetelmä suodatinpanoksen valmistamiseksi
FI954037A0 (fi) Menetelmä karboksyylihapon puhdistamiseksi
DK0566468T3 (da) Fremgangsmåde til fremstilling af et biphenylderivat
DK0506973T3 (da) Fremgangsmåde til fremstilling af et aminocarboxylsyresalt
DK0741732T3 (da) Fremgangsmåde til dannelse af et clavulansyresalt
NO964154D0 (no) Fremgangsmåte for fremstilling av en konstruksjonsdel
PT770687E (pt) Processo para a producao de nicotinamida
DK0721743T3 (da) Forbedret fremgangsmåde til fremstilling af et skaldyrprodukt
DE69516097D1 (de) Ein Beschichtungsverfahren
ZA959443B (en) Process for manufacturing clavulanic acid salt
ID21998A (id) Proses untuk pembuatan secara kontinyu senyawa alkil 5-formilvalerat
DE69618045D1 (de) Clavulansäure Salz
DK0509342T3 (da) Fremgangsmåde til fremstilling af kileformede strukturer
DK0692511T3 (da) Fremgangsmåde til fremstilling af et farvehjælpemiddel
BR9608469A (pt) Processo para a preparação de derivados do ácido carboxílico
FI942403A0 (fi) Menetelmä orgaanisen hapon tai sen suolan valmistaMenetelmä orgaanisen hapon tai sen suolan valmistamiseksi miseksi
FI971675A0 (fi) Menetelmä bradykiniinin liittyvien tilojen inhiboimiseksi
BR9603223A (pt) Processo para a preparação de aminocarboniltriazolinonas substituídas
DK0789700T3 (da) Forbedret fremgangsmåde til fremstilling af et D-(+)-biotin-mellemprodukt
FI972694A (fi) Uusi menetelmä sameridiinin valmistamiseksi