BE904831A - Composition d'activateur tissulaire du plasminogene. - Google Patents
Composition d'activateur tissulaire du plasminogene.Info
- Publication number
- BE904831A BE904831A BE0/216712A BE216712A BE904831A BE 904831 A BE904831 A BE 904831A BE 0/216712 A BE0/216712 A BE 0/216712A BE 216712 A BE216712 A BE 216712A BE 904831 A BE904831 A BE 904831A
- Authority
- BE
- Belgium
- Prior art keywords
- amino acid
- activator composition
- tissue activator
- plasminogen tissue
- acid sequence
- Prior art date
Links
- 102000013566 Plasminogen Human genes 0.000 title 1
- 108010051456 Plasminogen Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- PUUYVMYCMIWHFE-BQBZGAKWSA-N Gly-Ala-Arg Chemical group NCC(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CCCN=C(N)N PUUYVMYCMIWHFE-BQBZGAKWSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858513358A GB8513358D0 (en) | 1985-05-28 | 1985-05-28 | Formulation |
| GB858521704A GB8521704D0 (en) | 1985-08-31 | 1985-08-31 | Formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE904831A true BE904831A (fr) | 1986-11-27 |
Family
ID=26289289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/216712A BE904831A (fr) | 1985-05-28 | 1986-05-27 | Composition d'activateur tissulaire du plasminogene. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5112609A (enExample) |
| AT (1) | AT391812B (enExample) |
| AU (1) | AU569429B2 (enExample) |
| BE (1) | BE904831A (enExample) |
| CA (1) | CA1297008C (enExample) |
| CH (1) | CH664495A5 (enExample) |
| DE (1) | DE3617753A1 (enExample) |
| DK (1) | DK163174C (enExample) |
| ES (1) | ES8706443A1 (enExample) |
| FI (1) | FI85334C (enExample) |
| FR (1) | FR2593393B1 (enExample) |
| GB (1) | GB2176703B (enExample) |
| GR (1) | GR861365B (enExample) |
| HU (1) | HU200695B (enExample) |
| IL (1) | IL78937A (enExample) |
| IT (1) | IT1191925B (enExample) |
| LU (1) | LU86445A1 (enExample) |
| NL (1) | NL8601354A (enExample) |
| NO (1) | NO171344C (enExample) |
| NZ (1) | NZ216306A (enExample) |
| PT (1) | PT82647B (enExample) |
| SE (1) | SE462893B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI831484A7 (fi) * | 1982-05-05 | 1983-11-06 | Genentech Inc | Ihmiskudoksen plasminogeenien aktivaattori. |
| SU1662352A3 (ru) * | 1982-05-05 | 1991-07-07 | Генентек, Инк (Фирма) | Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа |
| US5185259A (en) * | 1982-05-05 | 1993-02-09 | Genentech, Inc. | Truncated human tissue plasminogen activator |
| WO1986005096A1 (en) * | 1985-03-06 | 1986-09-12 | Survival Technology, Inc. | Protein absorption enhancing agents |
| ZW14486A1 (en) * | 1985-07-29 | 1986-10-22 | Smithkline Beckman Corp | Pharmaceutical dosage unit |
| US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
| US5034225A (en) * | 1985-12-17 | 1991-07-23 | Genentech Inc. | Stabilized human tissue plasminogen activator compositions |
| US4976959A (en) * | 1986-05-12 | 1990-12-11 | Burroughs Wellcome Co. | T-PA and SOD in limiting tissue damage |
| JPH0680015B2 (ja) * | 1986-05-12 | 1994-10-12 | ザ ウエルカム ファウンデーション リミテッド | 医薬組成物 |
| GB8619098D0 (en) * | 1986-08-05 | 1986-09-17 | Wellcome Found | Combination |
| US5149533A (en) * | 1987-06-04 | 1992-09-22 | Zymogenetics, Inc. | Modified t-PA with kringle-/replaced by another kringle |
| US5270198A (en) * | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
| GB8814604D0 (en) * | 1988-06-20 | 1988-07-27 | Wellcome Found | Medicaments |
| WO1990001334A1 (en) * | 1988-08-05 | 1990-02-22 | Codon | Formulations for plasminogen activator using aspartate |
| GB8819607D0 (en) * | 1988-08-17 | 1988-09-21 | Wellcome Found | Novel combination |
| US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
| US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
| US4980165A (en) * | 1989-01-27 | 1990-12-25 | Genetics Institute, Inc. | Pharmaceutical formulations of plasminogen activator proteins |
| DE3942142A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | Stabilisierung von glykosyliertem t-pa |
| GB9000629D0 (en) * | 1990-01-11 | 1990-03-14 | Porton Prod Ltd | Tissue plasminogen activator |
| DE69333127T2 (de) * | 1992-06-03 | 2004-05-06 | Genentech, Inc., South San Francisco | Varianten des Gewebeplasminogenaktivators mit verbesserter therapeutischer Wirkung |
| DE69719265T2 (de) * | 1996-09-06 | 2003-12-04 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute, Kumamoto | Medizinische Zusammensetzung die Gewebeplasminogenaktivator und Nikotinamid enthält |
| US6355243B1 (en) * | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
| US7544500B2 (en) | 1999-11-13 | 2009-06-09 | Talecris Biotherapeutics, Inc. | Process for the production of a reversibly inactive acidified plasmin composition |
| US20030077682A1 (en) * | 2001-09-07 | 2003-04-24 | Hung Paul Porwen | Human tissue urokinase type plasminogen activator formulation |
| NZ589557A (en) * | 2008-06-04 | 2012-08-31 | Talecris Biotherapeutics Inc | Immobilised streptokinase, method and kit for preparing plasmin |
| HUE025670T2 (en) | 2009-03-03 | 2016-04-28 | Grifols Therapeutics Inc | A method for producing plasminogen |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998947A (en) * | 1973-11-30 | 1976-12-21 | Pierre Fabre S.A. | Process for obtaining a plasminogen activator |
| FR2252842B1 (enExample) * | 1973-12-03 | 1977-11-04 | Fabre Sa Pierre | |
| DE3015699C2 (de) * | 1979-04-26 | 1982-07-15 | Asahi Kasei Kogyo K.K., Osaka | Herstellung eines Plasminogen-Aktivators |
| ES8106836A2 (es) * | 1979-07-27 | 1981-10-01 | Fabre Sa Pierre | Procedimiento de obtencion de un activador del plasminogeno |
| NL8003402A (nl) * | 1980-06-11 | 1982-01-04 | Leuven Res & Dev Vzw | Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking. |
| ZA831399B (en) * | 1982-03-05 | 1984-02-29 | Health Lab Service Board | New fibrinolytic enzymes and methods for their production and pharmaceutical compositions containing them |
| AR241654A1 (es) * | 1982-05-05 | 1992-10-30 | Genentech Inc | Procedimiento para producir activador de plasminogeno de tejido humano. |
| JPS5951220A (ja) * | 1982-08-02 | 1984-03-24 | Asahi Chem Ind Co Ltd | 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤 |
| EP0124613B1 (en) * | 1982-10-29 | 1992-12-30 | MITSUI TOATSU CHEMICALS, Inc. | Novel plasminogen activator derived from human kidneys, process for its preparation, and thrombolytic drug containing the same |
| AU554862B2 (en) * | 1982-12-14 | 1986-09-04 | Implico B.V. | Plasminogen activator isolated by affinity chromatography |
| EP0112122B1 (en) * | 1982-12-14 | 1991-08-28 | South African Inventions Development Corporation | Plasminogen activator |
| JPS59196824A (ja) * | 1983-04-21 | 1984-11-08 | Kowa Co | 吸着防止剤 |
| DE3584902D1 (de) * | 1984-02-29 | 1992-01-30 | Asahi Chemical Ind | Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren. |
| DE3439980A1 (de) * | 1984-11-02 | 1986-05-07 | Behringwerke Ag, 3550 Marburg | Verfahren zur reinigung sowie pasteurisierung von urokinase |
| US4929444A (en) * | 1985-05-28 | 1990-05-29 | Burroughs Wellcome Co. | Low pH pharmaceutical formulation containing t-PA |
| ZW14486A1 (en) * | 1985-07-29 | 1986-10-22 | Smithkline Beckman Corp | Pharmaceutical dosage unit |
| JPH0672105B2 (ja) * | 1985-10-02 | 1994-09-14 | 持田製薬株式会社 | 血栓溶解剤及びその製法 |
| DE59009964D1 (de) * | 1989-09-13 | 1996-01-25 | Rieter Ag Maschf | Verfahren zum Starten eines Arbeitsablaufs eines Bedienungsautomaten an einer Textilmaschine |
-
1986
- 1986-05-27 NO NO862095A patent/NO171344C/no unknown
- 1986-05-27 SE SE8602404A patent/SE462893B/sv not_active IP Right Cessation
- 1986-05-27 CA CA000510096A patent/CA1297008C/en not_active Expired - Fee Related
- 1986-05-27 GR GR861365A patent/GR861365B/el unknown
- 1986-05-27 GB GB08612781A patent/GB2176703B/en not_active Expired
- 1986-05-27 IL IL78937A patent/IL78937A/xx not_active IP Right Cessation
- 1986-05-27 HU HU862239A patent/HU200695B/hu not_active IP Right Cessation
- 1986-05-27 CH CH2127/86A patent/CH664495A5/de not_active IP Right Cessation
- 1986-05-27 AU AU57965/86A patent/AU569429B2/en not_active Ceased
- 1986-05-27 LU LU86445A patent/LU86445A1/fr unknown
- 1986-05-27 FR FR8607553A patent/FR2593393B1/fr not_active Expired
- 1986-05-27 PT PT82647A patent/PT82647B/pt not_active IP Right Cessation
- 1986-05-27 AT AT0141186A patent/AT391812B/de not_active IP Right Cessation
- 1986-05-27 ES ES555352A patent/ES8706443A1/es not_active Expired
- 1986-05-27 FI FI862226A patent/FI85334C/fi not_active IP Right Cessation
- 1986-05-27 BE BE0/216712A patent/BE904831A/fr not_active IP Right Cessation
- 1986-05-27 NZ NZ216306A patent/NZ216306A/xx unknown
- 1986-05-27 DK DK246886A patent/DK163174C/da not_active IP Right Cessation
- 1986-05-27 DE DE19863617753 patent/DE3617753A1/de active Granted
- 1986-05-27 IT IT48064/86A patent/IT1191925B/it active
- 1986-05-27 NL NL8601354A patent/NL8601354A/nl not_active Application Discontinuation
-
1990
- 1990-05-21 US US07/527,634 patent/US5112609A/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: THE WELLCOME FOUNDATION LTD Effective date: 19950531 |